NanoTek^® 
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Microfluidic Flow-Chemistry on Demand

The NanoTek accelerates rapid optimization of novel compounds, delivering increased reaction efficiency and reduced precursor usage.

SYNTHESIZED COMPOUNDS TO DATE

Articles:

• Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer
  Kealey, S.; Plisson, C.; Collier, T. L.; Long, N. J.; Husbands, S. M.; Martarello, L.; Gee, A. D.
  Org. Biomol. Chem., 2011. [Epub 25 March 2011]
  

• Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-d-arabinofuranosyl)-2-nitroimidazole using microfluidic technology
  Bouvet, V. R.; Wuest, M.; Wiebe, L. I.; Wuest, F.
  Nucl Med Biol., 2010 February, 38 (2):235-245. [Epub 3 December 2010]
  

• Fast and high-yield microreactor syntheses of ortho-substituted [¹⁸F]fluoroarenes from reactions of [¹⁸F]fluoride ion with diaryliodonium salts
  Chun, J.-H.; Lu, S.; Lee, Y.-S.; Pike, V. W.
  J. Org. Chem., 2010, 75 (10):3332-3338.
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• Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil    ([18F]-FIAU)
  Anderson, H.; Pillarsetty, N.; Cantorias, M.; Lewis, J.S.
  Nucl Med Biol. 2010 May, 37(4):439-42.
  

• Microfluidic approach for fast labeling optimization and dose-on-demand implementation
  Pascali, G.; Mazzone, G.; Saccomanni, G.; Manera, C.; Salvadori, P. A.
  Nuclear Medicine and Biology, 2010; 37:547-555.
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• A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
  Palmieri, A.; Ley, S. V.; Hammond, K.; Polyzos, A.; Baxendale, I. R.
  Tetrahedron Letters, 2009, 50 (26):3287-3289.
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• Single-step high-yield radiosynthesis and evaluation of a sensitive F-labeled ligand for imaging brain Peripheral benzodiazepine receptors with PET
  Briard, E.; Zoghbi, S. S.; Simeon, F. G.; Imaizumi, M.; Gourley, H.; Shetty, H. U.; Lu, S.; Fujita, M.; Innis, R. B.; Pike, V. W.
  J. Med. Chem., 2009 February 12, 52 (3):688-699.
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• Synthesis of [¹⁸F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies
  Lu, S.; Giamis, A. M.; Pike, V. W.
  Curr. Radiopharm., 2009;2(1):nihpa81093.
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Product Note:

• NanoTek LF
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• NanoTek Benefits

Application Notes:

• Sequential back-to-back preparation of two radiotracers from one delivery of ¹⁸F
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• Using NanoTek in a GMP-compliant laboratory
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• Preparation of [¹⁸F]altanserin using the NanoTek LF
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• Simultaneous preparation of two C-11 radiotracers, raclopride and dihydrotetrabenazine (DTBZ), on NanoTek LF
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• Determining the heating profile and improved reliability using a vacuum system with the NanoTek LF concentrator 2 and a 5-ml reaction vial for vial-based FLT production
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• Controlling external HPLC components with a NanoTek
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