NanoTek^®
A Microfluidic Flow-Chemistry System

The NanoTek is a modular, liquid-flow-based ¹⁸F microchemistry system with the ability to combine both microscale and macroscale process steps in PET synthesis. Modular components give the user maximum flexibility producing positron emission tomography compounds for both discovery and clinical applications. Only the NanoTek offers high-yield, high-purity microsynthesis of multiple positron emission tomography (PET) compounds in 2 minutes.

Microfluidic Flow-Chemistry on Demand for PET synthesis that is:

• Fast – 35 times faster than conventional macrochemistry. Synthesis times of 1 to 2 minutes
• Flexible – Multiple biomarker batches produced from a single 18F batch
• Efficient – 2.5 times greater yields and lower reagent usage
• Expandable – Modular hardware and software adapt to research needs
• Integrated – Microscale purification is built in or can accommodate an external pump
• Rugged – Solvent-tolerant, high-temperature, and high-pressure reactors
• Versatile – Microscale and macroscale liquid, gas, and solid phase reactor components

Presentations:

• Why Microfluidic Synthesis? Presented by Kelvin Hammond at the 2011 SNM Annual Meeting.
• Sequential preparation of two different PET radiotracers employing the Advion NanoTek synthesis system                                                                                                                                    Presented by Thomas Collier at the 2011 SNM Annual Meeting

Articles:

• Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer
  Kealey, S.; Plisson, C.; Collier, T. L.; Long, N. J.; Husbands, S. M.; Martarello, L.; Gee, A. D.
  Org. Biomol. Chem., 2011. [Epub 25 March 2011]

• Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-d-arabinofuranosyl)-2-nitroimidazole using microfluidic technology
  Bouvet, V. R.; Wuest, M.; Wiebe, L. I.; Wuest, F.
  Nucl Med Biol., 2010 February, 38 (2):235-245. [Epub 3 December 2010]
  

• Fast and high-yield microreactor syntheses of ortho-substituted [18F]fluoroarenes from reactions of [18F]fluoride ion with diaryliodonium salts
  Chun, J.-H.; Lu, S.; Lee, Y.-S.; Pike, V. W.
  J. Org. Chem., 2010, 75 (10):3332-3338.

• Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil    ([18F]-FIAU)
  Anderson, H.; Pillarsetty, N.; Cantorias, M.; Lewis, J.S.
  Nucl Med Biol. 2010 May, 37(4):439-42.

• Microfluidic approach for fast labeling optimization and dose-on-demand implementation Pascali, G.; Mazzone, G.; Saccomanni, G.; Manera, C.; Salvadori, P. A.
  Nuclear Medicine and Biology, 2010; 37:547-555.
  
  
• A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
  Palmieri, A.; Ley, S. V.; Hammond, K.; Polyzos, A.; Baxendale, I. R.
  Tetrahedron Letters, 2009, 50 (26):3287-3289.
  
  
• Single-step high-yield radiosynthesis and evaluation of a sensitive F-labeled ligand for imaging brain Peripheral benzodiazepine receptors with PET
  Briard, E.; Zoghbi, S. S.; Simeon, F. G.; Imaizumi, M.; Gourley, H.; Shetty, H. U.; Lu, S.; Fujita, M.; Innis, R. B.; Pike, V. W.
  J. Med. Chem., 2009 February 12, 52 (3):688-699.
  
  
• Synthesis of [18F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies
  Lu, S.; Giamis, A. M.; Pike, V. W.
  Curr. Radiopharm., 2009;2(1):nihpa81093.

Application Note: Back-to-Back Production - One delivery of [18F], multiple syntheses

SELECT MICROFLUIDIC FLOW-CHEMISTRY REFERENCES: Articles, Product Note, Application Notes, Presentations