NanoTek Microfluidic Synthesis System

Chemistry on Demand

Only the NanoTek Microfluidic Synthesis System offers high-yield, high-purity microsynthesis of multiple positron emission tomography (PET) compounds in 2 minutes.

• Fast - 35 times faster than conventional macrochemistry. Synthesis times of 1 to 2 minutes
• Flexible - Multiple biomarker batches produced from a single ¹⁸F batch
• Efficient - 2.5 times greater yields and lower reagent usage
• Expandable - Modular hardware and software adapt to research needs
• Integrated - Microscale purification is built in or can accommodate an external pump
• Rugged – Solvent-tolerant, high-temperature, and high-pressure reactors
• Versatile - Microscale and macroscale liquid, gas, and solid phase reactor components

NanoTek - Liquid Flow Reactor System

The NanoTek Microfluidic Synthesis System is a modular, liquid-flow-based ¹⁸F microchemistry system with the ability to combine both microscale and macroscale process steps. Modular components give the user maximum flexibility producing positron emission tomography compounds for both discovery and clinical applications.

References:

A microfluidic system for [¹¹C]CO carbonylation reactions

A. Smith, D. Patton, A. Giamis, J.C. Matteo

J. Nucl. Med. Meeting Abstracts, May 2008; 49:46P

Clinical Microfluidic Production of [¹⁸F]Fluoromisonidazol (FMISO)

A.M. Giamis, R. Price, C. Nahmius, J. Matteo

J. Nucl. Med. Meeting Abstracts, May 2008; 49:300P

Rapid optimization of the synthesis of [¹⁸F]fallypride in a micro-reactor

S. Lu, A. M. Giamis, J. Matteo, V. W. Pike

High Yield Synthesis of [¹⁸F]Fallypride Using a Microfluidic Automated System

L. Brichard, A. Giamis, F.I. Aigbirhio

XI TurkuPet Symposium Abstracts, May 2008