RePlay® Select References
Proteomic researchers have demonstrated the benefits of RePlay as follows:

Journal Articles
Proteomics characterization of extracellular space components in the human aorta
Didangelos, A.; Yin, X.; Mandal, K.; Baumert, M.; Jahangiri, M.; Mayr, M.
Mol. Cell. Proteomics. 2010 Sep; 9(9):2048-62.
Pressurized pepsin digestion in proteomics: An automatable alternative to trypsin for integrated top-down bottom-up proteomics
López-Ferrer, D.; Petritis, K.; Robinson, E.W.; Hixson, K.K.; Tian, Z.; Lee, J.H.; Tolić, N.; Weitz, K.K.; Belov, M.E.; Smith, R.D.; Paša-Tolić, L.
Mol. Cell. Proteomics. 2010; Sep 10. [Epub ahead of print]
Quantitative proteomic analysis of single pancreatic islets
Waanders, L.F.; Chwalek, K.; Monetti, M.; Kumar, C.; Lammert, E.; Mann, M.
Proc. Natl. Acad. Sci. U.S.A. 2009 Nov 10; 106(45):18902-7.
A novel chromatographic method allows on-line reanalysis of the proteome
Waanders, L.F.; Almeida, R.; Prosser, S.; Cox, J.; Eikel, D.; Allen, M.H.; Schultz, G.A.; Mann, M.
Mol. Cell. Proteomics. 2008 Aug; 7(8):1452-9.
Application Notes
Increased information gain from complex proteomic samples using RePlay: Dividing a nanoLC flow post-column and exploiting twice the analytical possibilities from one sample injection
Eikel, D. ; Koller, T.*; Chen, E.*; Prosser, S.
Advion Application Note (*Stony Brook University, Stony Brook, NY, USA)
“RePlay” significantly increases the number of protein assignments from complex proteomic samples
Schneider, A.; Lubeck, M.; Baessmann, C.; Almeida, R.
Bruker Daltonics Application Note # LCMS-54
Oral Presentations
Integrated top-down/bottom-up proteomics for the characterization of protein isoforms
Robinson, E.W.; Paša-Tolić, L.; Tian, Z.; Tolić, N.; López-Ferrer, D.; Zhang, H.; Wu, S.; Smith, R.D.
Presented at 7th Advion Users’ Meeting at 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, UT, May 2010.
uTOPIA: Universal tool for on-line processing and iterative analysis
Caldwell Busby, J.; Pascal, B.; Rose, K.; Cavett, V.; Hoopmann, M.; MacCoss, M.
Presented at 7th Advion Users’ Meeting at 58th ASMS Conference on Mass Spectrometry and Allied Topics, Salt Lake City, UT, May 2010.
Digests by consecutive, targeted LC-MSMS runs with both CID and ETD
Albers, C., Hartmer, R.; Belau, E.; Almeida, R.; Schneider, A.; Lubeck, M.
Presented at 6th Advion Users’ Meeting at 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, PA, May 2009.
Integrated “RePlay” top-down/bottom-up proteomics
Petritis, K.; López-Ferrer, D.; Tian, Z.; Robinson, E.W.; Belov, M.; Smith, R.D.; Paša-Tolić, L.
Presented at 6th Advion Users’ Meeting at 57th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia, PA, May 2009.
Characterization and novel experimental designs using RePlay and LC/MS
Caldwell Busby, J.; Cavett, V.; Pascal, B.; Dorsey, C.; Prater, S.; Cleveland, J.; Prosser, S.; Corso, T.
Presented at 5th Advion Users’ Meeting at 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, May 2008.
Mining the 24-hour proteome Master, S.; Bierl, C.; Everett, L.; Li, L.; Ryvkin, P.; Prosser, S.; Schultz, G. Presented at 5th Advion Users’ Meeting at 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, May 2008.
Poster Presentations
Up two speed: rapid sample characterization by combining RePlay and UPLC-MS for duplicate analysis in half the time
Sprenger, R.R.; Jensen, O.N.
J. Am. Soc. Mass Spectrom. 2010; 21(5 Suppl):S80.
Enabling data-dependent gas-phase fractionation in a single chromatographic-based shotgun proteomics analysis
Almeida, R.; Alpha, C.; Allen, M.
J. Am. Soc. Mass Spectrom. 2010; 21(5 Suppl):S81.
Increased sequence coverage in complex protein digests by consecutive, targeted LC-MSMS runs with both CID and ETD
Schneider, A.; Lubeck, M.; Almeida, R., Clemens, P.
J. Biomol. Tech. 2010 September; 21(3 Suppl):S55–S56.
Combining nanoLC/MS with low volume fractionation in a single LC/MS experiment
Almeida, R.; Waanders, L. F.; Bandilla, P.; Allen, M.; Mann, M.
Presented at 18th International Mass Spectrometry Conference, Bremen, Germany, Aug. - Sept. 2009.
Characterization of protein isoforms using tandem MS of intact and on-line digested proteins from a single intact protein HPLC separation
Robinson, E. W.; Tian, Z.; Tolić, N.; López-Ferrer, D.; Petritis, K.; Adkins, J. N.; Smith, R. D.; Paša-Tolić, L.
J. Am. Soc. Mass Spectrom. 2009; 20(5 Suppl):S39.
Integration of top-down and bottom-up approaches: Application of RePlay for confident protein/peptide identifications by on-line post-column digestion and high-resolution MS
Petritis, K.; López-Ferrer, D.; Tian, Z.; Robinson, E.; Belov, M.; Paša-Tolić, L.; Fjeldsted, J.; Leonard, L.; Prosser, S. J.; Schriemer, D.; Lewis, D. F.; Smith, R. D.
J. Am. Soc. Mass Spectrom. 2009; 20(5 Suppl):S123.
RePlay combined with a scheduled precursor list (SPL) significantly improves the number of protein assignments from complex proteomic samples
Eikel, D.; Albers, C.; Lubeck, M.; Rule, G. S.; Prosser, S. J.
J. Am. Soc. Mass Spectrom. 2009; 20(5 Suppl):S99-100.
A novel approach enabling dual MS-analyses of a single LC-injection with excellent sensitivity
Waanders, L. F.; Almeida, R.; Bandilla, P.; Prosser, S.; Cox, J.; Allen, M.; Schultz, G.; Mann, M.
J. Am. Soc. Mass Spectrom. 2008; 19(5 Suppl):S110.
Combining exploratory & targeted analysis for identification & quantitation of biomarker candidates in a single nanoLC/MS run
Almeida, R.; Waanders, L. F.; Schultz, G. A.; Bandilla, P.; Allen, M.; Mann, M.
J. Am. Soc. Mass Spectrom. 2008; 19(5 Suppl):S53.
Déjà vu LC-MS/MS: How to RePlay an LC-MS/MS chromatogram without injecting the sample again
Eikel, D.; Prosser, S. J.; Schultz, G. A.; Almeida, R.; Allen, M. H.
J. Am. Soc. Mass Spectrom. 2008; 19(5 Suppl):S110.
Improved overall mass spectral acquisition rates using a novel HPLC storage loop
Bierl, C.; Prosser, S. J.; Master, S. R.
J. Am. Soc. Mass Spectrom. 2008; 19(5 Suppl):S126.
Mapping post translational modifications using single aliquot/dual scanning method
Cavett, V.; Prater, S. M.; Prosser, S. J.; Cleveland, J. L.; Coenen, S.; Dorsey, F. C..; Corso, T. N.; Busby, J.
J. Am. Soc. Mass Spectrom. 2008; 19(5 Suppl):S125.