| Our
Metabolite Identification capabilities offer greater than 10 times more
sensitivity than LC/MS/MS for detection of low level, potentially active
or toxic recirculating metabolites.
- Characterize “hot” radio-labeled LC fractions
- Obtain structural information on trace-level metabolites by infusing
collected HPLC fractions
- Low flow rates enable signal averaging for improved signal-to-noise
- Rapidly switch between mass spectrometry platforms to obtain positive
ion, precursor ion, neutral loss scanning or MSn analysis as well as
accurate mass
- Less analyte required to get the same data quality versus LC/MS/MS
Learn more about this application
by viewing the following web presentation
Metabolite
Identification with Weiping Zhao of Bristol Myers Squibb
Integrated approach benefits
from, selectivity/sensitivity of off-line radiochemical detection, rapid
data generation by online LC/MS/MS, and extensive structural elucidation
by fraction collection/infusion MS”; J.Josephs et all; ASMS 2007
Proceedings Indianapolis, IN
How
it works >>
Following are peer reviewed
articles, application notes, and posters demonstrating Advion's technology.
You will need to sign in to access the documents listed below.
You must register before you sign in for the first time.
Product Notes
Articles:
- Rapid metabolite identification with sub parts-permillion mass accuracy
from biological matrices by direct infusion nanoelectrospray ionization
after clean-up on a ZipTip and LTQ/Orbitrap mass spectrometry; Erve,
J..; DeMaio, W.; Talaat, R. Rapid Commun Mass Spectrom. 2008;
22: 3015–3026
Sign
in to request hardcopy.
- Measurement of Total Acid Number (TAN) and TAN Boiling Point Distribution
in Petroleum Products by Electrospray Ionization Mass Spectrometry.
K. Qian, et. al. Anal Chem. 2008 Jan 8
Sign in to request hardcopy.
- Comparison of a two-dimensional liquid chromatography/mass spectrometry
approach with a chip-based nanoelectrospray device for structural elucidation
of metabolites in a human ADME study using a quadrupole time-of-flight
mass spectrometer; Trunzer, M.; Graf, D.; Kiffe, M. Rapid Commun
Mass Spectrom. 2007;21(6):937-44
Sign in to request hardcopy.
- Quantitation of Cotinine in Nonsmoker Saliva Using Chip-Based Nanoelectrospray
Tandem Mass Spectrometry; Tompkins, B.A.; Van Berkel G.J.; Jenkins,
R.A.; Counts R.W. J Anal Toxicol. 2006 Apr;30(3):178-86(9)
Sign in to request hardcopy.
- "The Combination of Liquid Chromatography/Tandem Mass Spectrometry
and Chip-Based Infusion for Improved Screening and Characterization
of Drug Metabolites"; Roland F. Staack, Emmanuel Varesio, and Gerard
Hopfgartner; Rapid Commun Mass Spectrom.; 1-3-2005
Sign in to request hardcopy.
Scientific Posters:
- Accelerating Metabolite Identification Using Automated Chip-Based
Infusion Nanoelectrospray on a Q-TOF - C. Van Pelt
Sign in to request hardcopy.
- Use of Automated Nanoelectrospray for Drug Metabolite Structure Elucidation
- D. Borts - GlaxoSmithKline
Sign in to download.
|
