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Our Metabolite Identification capabilities offer greater than 10 times more sensitivity than LC/MS/MS for detection of low level, potentially active or toxic recirculating metabolites.
- Characterize “hot” radio-labeled LC fractions
- Obtain structural information on trace-level metabolites by infusing
collected HPLC fractions
- Low flow rates enable signal averaging for improved signal-to-noise
- Rapidly switch between mass spectrometry platforms to obtain positive
ion, precursor ion, neutral loss scanning or MSn analysis as well as
accurate mass
- Less analyte required to get the same data quality versus LC/MS/MS
Learn more about this application
by viewing the following web presentation
Metabolite
Identification with Weiping Zhao of Bristol Myers Squibb
Integrated approach benefits from, selectivity/sensitivity of off-line radiochemical detection, rapid data generation by online LC/MS/MS, and extensive structural elucidation by fraction collection/infusion MS”; J.Josephs et all; ASMS 2007 Proceedings Indianapolis, IN
How it works >>
Following are peer reviewed articles, application notes, and posters demonstrating Advion's technology. You will need to sign in to access the documents listed below.
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Product Notes
Articles:
- Measurement of Total Acid Number (TAN) and TAN Boiling Point Distribution in
Petroleum Products by Electrospray Ionization Mass Spectrometry.
K. Qian, et. al. Anal Chem. 2008 Jan 8
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- Comparison of a two-dimensional liquid chromatography/mass spectrometry approach with a chip-based nanoelectrospray device for structural elucidation of metabolites in a human ADME study using a quadrupole time-of-flight mass spectrometer; Trunzer, M.; Graf, D.; Kiffe, M. Rapid Commun Mass Spectrom. 2007;21(6):937-44
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- Quantitation of Cotinine in Nonsmoker Saliva Using Chip-Based Nanoelectrospray Tandem Mass Spectrometry; Tompkins, B.A.; Van Berkel G.J.; Jenkins, R.A.; Counts R.W. J Anal Toxicol. 2006 Apr;30(3):178-86(9)
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- "The Combination of Liquid Chromatography/Tandem Mass Spectrometry and Chip-Based Infusion for Improved Screening and Characterization of Drug Metabolites"; Roland F. Staack, Emmanuel Varesio, and Gerard Hopfgartner; Rapid Communications in Mass Spectrometry; 1-3-2005
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Scientific Posters:
- Accelerating Metabolite Identification Using Automated Chip-Based Infusion Nanoelectrospray on a Q-TOF - C. Van Pelt
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- Use of Automated Nanoelectrospray for Drug Metabolite Structure Elucidation - D. Borts - GlaxoSmithKline
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