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Stable, reproducible chip-based infusion for the best mass accuracy, resolution, and sensitivity from FTMS instruments on projects involving Top-Down Proteomics sequencing.
- Characterize phosphorylation, glycosylation, and other post-translational modification sites
- Low sample volume (2 -10 microliters) and the ability to return unused samples for maximum flexibility
- Automated infusion for acquisition of multiple scan MS/MS data
"We are encouraged by the results we have obtained using TriVersa NanoMate and LTQ Orbitrap demonstrating their suitability for top-down proteomics of small proteins. Sub-picomole amounts of intact proteins proved sufficient to obtain high quality MS, MS2 and MS3 spectra, with mass accuracies in the few ppm range."
Top-down protein sequencing and MS3 on a hybrid linear quadrupole ion trap orbitrap mass spectrometer
B. Macek, L. Waanders, J.V. Olsen, M. Mann Mol.Cell.Prot. 2006; 5: 949-958
How it works >>
Following are peer reviewed articles, application notes, and posters demonstrating Advion's technology. You will need to sign in to access the documents listed below.
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Product Notes:
Articles:
- At-line coupling of UPLC to chip-electrospray-FTICR-MS; Li, X.; Fekete, A.; Englmann, M.; Frommberger, M.; Lv, S.; Chen, G.; Schmitt-Kopplin, P. Anal Bioanal Chem. 2007 Sep 5; [Epub ahead of print]
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- "Top-down protein sequencing and MS3 on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer"; M. Mann - Max Planck Institute for Biochemistry; Molecular & Cellular Proteomics; 2-3-2006
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- "Top-Down Approaches for Measuring Expression Ratios of Intact Yeast Proteins Using Fourier Transform Mass Spectrometry"; N. Kelleher et al - University of Illinois Urbana; Analytical Chemistry; 1-3-2006
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- "Investigation of the Presence of b Ions in Electron Capture Dissociation Mass Spectra"; H. Cooper - University of Birmingham; JASMS; 12-3-2005
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- "Construction of a Hybrid Quadrupole/Fourier-Transform Spectrmeter for Versatile MS/MS Above 10 kDa"; S.M. Patrie, et.al. - University of Illinois at Urbana-Champaign; J. Am. Soc. Mass Spectrom.; 11-3-2004
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- "Improved Molecular Weight-Based Processing of Intact Proteins for Analysis by Q-FTMS with Automated MS/MS"; Du, Y, et.al. - University of Illinois at Urbana-Champaign; Analytical Chemistry; 5-3-2004
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- "Molecular-Level Description of Proteins from Saccharomyces cerevisiae using Q-FT Mass Spectrometry for Top Down Proteomics"; F. Meng, et.al. - University of Illinois at Urbana-Champaign; Analytical Chemistry; 4-3-2004
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- "Strategies for Automating Top Down Proteomics with Q-FT ICR MS"; S.M. Patrie, et.al. - University of Illinois at Urbana-Champaign; Int. J. Mass Spectrom.; 4-3-2004
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- "Targeted Analysis and Discovery of Posttranslational Modifications in Proteins from Methonogenic Archaea by Top-Down MS"; N. Kelleher, et.al. - Univeristy of Illinois; PNAS; 3-2-2004
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Application Notes:
- Identification of 2D Gel Fractionated Intact Proteins Using FT-ICR Mass Spectrometry; High Throughput
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Scientific Posters:
- Split SIEVE: Informatic Support for Differential Split LC-FTMS Experiments - M. Askenazi - Thermo BRIMS Center
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- Top-Down Analysis of Low Molecular Weight Human Plasma Proteome Using a Hybrid Ion Trap-Fourier Transform Mass Spectrometer - ThermoElectron Corporation
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