June 24, 2014

“The CMS is a very helpful instrument that has shorten product detection times.”

Professor Meng of the Beijing Institute of Technology uses mass spectrometry as a tool for synthetic intermediates. With a large number of products to run, Meng and his team needed to shorten product detection times.

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June 24, 2014

Determination of Emerging Nitrogenous Economic Adulterants in Milk Proteins by HPLC/Compact Mass Spectrometry

The ability to rapidly screen milk ingredients in the manufacturing plants for potential economic adulterants is becoming increasingly important.

A simpler and more cost-effective alternative for frontline screening has been developed.

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June 12, 2014

Utilizing a novel compact mass spectrometer (CMS) for the detection and quantification of chemical compounds related to cannabis

Regardless of the legal status of cannabis and its chemical compounds, both the quality control in legal markets as well as the law enforcement of it’s illegal status require simple, unequivocal and legally defendable analysis methods for the detection and quantification of its major chemical compounds.

Whenever a detector of high selectivity and sensitivity is required, a mass spectrometry based analysis workflow is usually the method of choice and we here demonstrate the analysis of delta9-Tetrahydrocannabinol (THC), Canabidiol (CBD) and Canabinol (CBN) utilizing a novel compact mass spectrometer (expression-S, Advion, NY) coupled to ultra-high performance liquid chromatography (UHPLC) or thin layer chromatography (TLC).

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June 12, 2014

On-Demand Webinar: HRMS, Chemical Modification and Liquid Extraction Surface Analysis for Lipidome Profiling of Colon Adenocarcinom

In this presentation, the development and application of a straightforward and high throughout analysis strategy consisting of high-resolution ‘shotgun’ mass spectrometry (MS), ‘targeted’ tandem mass spectrometry (MS/MS), functional group specific chemical modification and in situ liquid extraction of cell culture samples is described for the comprehensive identification, characterization and quantification of multiple lipid classes from within a colon adenocarcinoma cell line, SW480, and its metastasized derivative, SW620.

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June 2, 2014

Evaluation of a compact mass spectrometer for routine support of pharmaceutical chemistry

Bu X1, Yang J2, Gong X2, Welch CJ3

1Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
2Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
3Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA

The suitability of a recently introduced inexpensive, compact mass spectrometer detector is evaluated for supporting pharmaceutical chemistry investigations. While high performance/high cost MS detectors dominate the marketplace, there is growing recognition of the need for a small, inexpensive MS detector with reduced capabilities for supporting synthetic chemistry investigations, where reduced sensitivity and unit mass resolution are often suitable for solving routine problems. In this study, the fundamental performance characteristics of the recently introduced Advion compact mass spectrometer were evaluated, investigating the use of the instrument for routine product and impurity identification, reaction monitoring, evaluation of potential genotoxic impurities and study of high molecular weight biomolecules. In general, the results of the evaluation show this compact and inexpensive mass spectrometer to be well suited for providing reliable support for pharmaceutical chemistry investigations, with sub-nanogram limit of detection and impurity identification below 0.1% being possible in some instance.

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May 21, 2014

Latest Peer-Reviewed Publication

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

Lucie Guetzoyan,a Richard J. Ingham,a Nikzad Nikbin,a Julien Rossignol,a Michael Wolling,a Mark Baumert,b Nicola A. Burgess-Brown,c Claire M. Strain- Damerell,c Leela Shrestha,c Paul E. Brennan,c Oleg Fedorov,c Stefan Knappc and Steven V. Ley*a

aInnovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK.

bAdvion Ltd, Harlow Enterprise Hub, Edinburgh Way, Harlow, Essex, CM20 2NQ, UK cStructural Genomics Consortium and Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK

A combination of conventional organic synthesis, remotely monitored flow synthesis and bioassay platforms, were used for the evaluation of novel inhibitors targeting bromodomains outside the wellstudied bromodomain and extra terminal (BET) family, here exemplified by activity measurements on the bromodomain of BRD9 protein, a component of some tissue-specific SWi/SNF chromatin remodelling complexes. The Frontal Affinity Chromatography combined with Mass Spectrometry (FAC-MS) method proved to be reliable and results correlated well with an independent thermal shift assay.

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May 21, 2014

“I recommend the expression CMS to all laboratories that routinely synthesize new small molecules”

Prof. Dr. Nathan Luedtke and his group at the University of Zurich utilize the CMS to address unresolved questions in DNA chemical biology by developing molecular probes for characterizing structure, function and dynamics of nucleic acids in vivo.

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May 21, 2014

Electrospray LC/MS response differences from equimolar quantities of drugs using a CMS equipped with atmospheric pressure ionization

The results from this study shed some light on the relative merits of APCI vs ESI as well as the importance of the optimal ionization polarity for the LC/MS determination of the selected acidic and basic small molecule drugs.

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May 21, 2014

Improved efficiency and faster answers — Compact mass spectrometry and U(H)PLC

Ultra (high) performance liquid chromatography (UPLC/UHPLC) is a relatively new technique, and is valued for its speed, efficiency and the quality of information provided. Many synthetic and medicinal chemistry laboratories are moving to tehis process to improve their workflows and save time.

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March 27, 2014

THC Plant Material Analysis

See two simple workflows for using Compact Mass Spectrometry for product control and law enforcement of cannabis related plant products.

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March 27, 2014

“No compromises mass spec for the chemist”

LabTube interviews David Patteson of Advion.

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March 27, 2014

“The expression CMS is easily serviceable by a non-expert.”

In this new profile, David Rotella of Montclair State University discusses how the expression CMS allowed him to bring industry-level technology to his small academic research group.

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January 23, 2014

On-Demand Webinar: Developing Photochemical Methods in Flow

Despite the potential to achieve novel and interesting chemical transformations, photochemistry still remains largely underutilized by the organic chemistry community. This presentation highlights ways of overcoming common difficulties.

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January 23, 2014

“There is no substitute for having a mass spectrometer a few steps away from your bench.”

In this new profile, John Matson of Virginia Tech discusses how the expression CMS has sped up small molecules and peptide synthesis as well as enabled qualitative decomposition studies on compounds.

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January 21, 2014

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Neil Vasdev, et al.
Chem. Commun., 2013,49, 8755-8757
DOI: 10.1039/C3CC45166F

Lead by Neil Vasdev, a collaborative group from Harvard Medical School, Massachusetts General Hospital, Northeastern University, and Advion, have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[18F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[18F]fluoroaniline were achieved within 3 minutes.

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January 9, 2014

Advion expands its line of compact mass spectrometers just for chemists

Advion now presents the new expression S compact mass spectrometer (CMS) designed specifically for academic, industry and research chemistry groups.

“Advion has brought to the chemist’s bench the best-in-class mass spectrometer performance previously reserved only for mass spec specialists.”

Now you have a choice for the best fit for your specific application.

The expression S is available now for orders with a 12 week lead time.

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December 12, 2013

Merck Millipore uses TLC/CMS to analyze Paracetamol in different formulations

Coupling the CAMAG TLC-MS interface with Advion’s expression CMS brings the specifi­city and sensitivity of mass spectrometry to TLC plate analysis.

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December 12, 2013

Merck Millipore determines caffeine in energy drinks using TLC/CMS

Now chemists can quickly, simply and unambiguously identify and quantify their compounds, even in complex mixtures, using TLC/CMS.

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December 11, 2013

ESI-Mass Spectrometer for as little as $1,300/month

Analyzes 80% of compounds that GC/MS can’t

LC/MS is the gold standard in separation science, but until now, was nancially out of reach for many teaching instutions. The expression CMS is an electrospray mass spectrometer that couples to most LC systems and is easy to maintain and use for even the most novice user.

Contact Advion today to learn more about creative nancing options available to small academic institutions. Ask about our leasing program.

December 6, 2013

“Our students no longer wait a month for results.”

In this new profile, Jessica Martin of Northeastern State University of Oklahoma discusses how the expression CMS provides answers faster than sending samples out. Previously, her students had to wait one month for results.

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