April 21, 2015

“EASY TO INSTALL, OPERATE, AND MOVE.”

“We have the expression linked to an HPLC instrument and it is used as an open access system. The combination of UV purity data along with MS confirmation is incredibly powerful for our chemists. The instrument is networked so our chemists can then process and review data from their desks.”

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April 21, 2015

DYESTUFF ANALYSIS OF CULTURAL HERITAGE OBJECTS by Direct Analysis Probe on a Compact Mass Spectrometer

The scientific investigation of cultural heritage objects is the only access to knowledge about long-gone, ancient societies and their cultural, technological as well as their social  stage of development. In addition, the materials used by our ancestors, e.g. their textiles and the organic dyestuff to colorize these materials, allow researchers to draw some conclusions about cultural exchanges and trading routes. But in-depth knowledge about materials and dyestuff is also of highest importance for proper conservation and restauration of these materials. Specimens, however, are rare and available only in minute amounts. For their investigation preferentially non-destructive or at least minimal invasive methods have to be used.

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April 20, 2015

Compact Mass Spectrometry (CMS) for the Detection and Quantification of Chemical Compounds Related to Cannabis

The cannabinoid makeup of cannabis has significantly changed over the past few decades. Efforts to increase the psychotropic effects of cannabis have resulted in a THC content for current strains of the crop of 30 to 40 percent compared with only 5 percent 30 years ago. Up-regulating the THC content of the plant causes a loss of other cannabinoids the plant is producing. Some of these other cannabinoids, such as CBD, are believed to be responsible for its medical benefits.

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March 22, 2015

Direct Mass Analysis of TLC Plates

Plate ExpressTM is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion’s expression® compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.

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March 22, 2015

NATURAL PRODUCT ANALYSIS Using Compact Mass Spectrometry with Polarity Switching and In-source CID

Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the  pharmaceutical drug development process and consequently half of all currently approved  drugs in the US are based on natural products. It is therefore not surprising that natural product analysis is a field of major interest world wide. Here, we present a simple example  of the added benefits of mass spectrometry in typical natural product analysis workflows based on an alcoholic extract of nutmeg.

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March 22, 2015

SUZUKI REACTION MONITORING Using Compact Mass Spectrometry with TLC Interface

This application note presents an online thin-layer chromatography (TLC)/CMS technique using the Advion expression compact mass spectrometer (CMS) and Plate ExpressTM interface to provide compound structural information without sample preparation after TLC separation. A Suzuki reaction for the synthesis of 4-aminobiphenyl will be demonstrated. The online TLC/CMS technique provides rapid and accurate determination of reaction mixture components without the need for off-line TLC sample preparation procedures.

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March 22, 2015

THC PLANT MATERIAL ANALYSIS Using Compact Mass Spectrometry for Product Control and Law Enforcement of cannabis-related Plant Products

Analysis of the active components of the cannabis sativa plant is required both for law enforcement where these compounds are illegal and also as a tool for product control and optimization in the increasing number of legal markets for cannabis plant products. Whenever simple, unequivocal and legally defensible  analysis methods for the detection and quantification of plant  metabolites are required, mass spectrometry is the detector of  choice.

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March 22, 2015

SUDAN DYES ANALYSIS Using Compact Mass Spectrometry with TLC Interface

Sudan Dyes are synthesized azo-dyes which are widely used to generate color in plastics, leather, fabrics, oil, waxes, etc. They are classified as Group 3 carcinogens by the International Agency for Research on Cancer (IARC) and are banned as food additives worldwide. However, in some countries these dyes are still occasionally used in order to intensify the color in products. In this note, a TLC/CMS method using expression compact mass spectrometer (CMS) coupled with the Plate ExpressTM Interface (Advion, Ithaca, NY) is introduced for the detection of 7 Sudan dyes in a chili matrix. The primary advantage of TLC/CMS analysis is the ability to sample directly from the TLC plate without further sample preparation after the TLC separation is done. Molecular weight information of sample components can be determined by the mass spectra from the eluted TLC spots.

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February 20, 2015

expression CMS: Compact. Fast. Easy. & Affordable

With over 20 years of mass spectrometry and chemistry expertise, Advion has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting.

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January 28, 2015

Expanded application note. DIRECT SAMPLE ANALYSIS: Detecting THC/Cannabinoids in Contraband by Compact Mass Spectrometry

This is an expanded application note with more data regarding direct sample analysis of THC in suspected contraband and on skin. Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.

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January 28, 2015

Screening of explosives residues without sample preparation using a direct sample analysis probe on the expression CMS

The ability to effectively screen passengers with minimal personal contact is critical. Ion mobility detectors used at many airports can be inaccurate and provide many false-positives and false-negatives. Advanced Imaging Technology (AIT) screening techniques are very useful for detecting concealed weapons and explosive devices located on passengers and/or in their belongings, however are unable to detect trace amounts of explosive residues.

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January 7, 2015

Direct Sample Analysis: Detecting THC/Cannabinoids in Contraband by Compact Mass Spectrometry

Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.

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December 30, 2014

Quantitative spatial analysis of the mouse brain lipidome by pressurized liquid extraction surface analysis (PLESA)

Reinaldo Almeida, Zane Berzina, Eva C. Arnspang, Jan Baumgart, Johannes Vogt, Robert Nitsch, and Christer S. Ejsing

Anal. Chem., Just Accepted Manuscript
DOI: 10.1021/ac503627z
Publication Date (Web): December 30, 2014
Copyright © 2014 American Chemical Society

 

Here we describe a novel surface sampling technique termed pressurized liquid extraction surface analysis (PLESA), which in combination with a dedicated high resolution shotgun lipidomics routine enables both quantification and in-depth structural characterization of molecular lipid species extracted directly from tissue sections.

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December 18, 2014

Direct Sample Analysis of “Fizzy Drinks”

Chemists are tasked with quickly identifying compounds created, ensuring quality of products or evaluating safety. Current techniques are adequate, but not all offer speed, data quality or ease-of-use provided by the expression Compact Mass Spectrometer (CMS). The expression CMS with the direct analysis probe (ASAP®) offers chemists the ability to rapidly analyze solids, liquids and powders without tedious and time consuming sample preparation.

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December 9, 2014

Using the TriVersa NanoMate with LESA for Analyte Profiling in Material Science

Surface analysis techniques have gained significant attention over the last couple of years with LESA being an interesting alternative to techniques such as SIMS or MALDI imaging. A new application note demonstrates practical applications for LESA in the material sciences.

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December 9, 2014

LC/MS Determination of Amino Acids Using Compact Mass Spectrometry

See examples for the determination of amino acids on a combined HPLC compact mass spectrometry (LC/CMS) system for the rapid detection and quantification of amino acids utilizing a novel mixed mode LC column.

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December 9, 2014

“Essential for any Lipidomics Laboratory.”

Associate Professor Christer S. Ejsing at the University of Southern Denmark uses the TriVersa NanoMate, as an essential laboratory instrument, for the development and applications of Lipidomic technology.

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October 28, 2014

New publication: Direct analysis of intact proteins from Escherichia coli colonies by LESA mass spectrometry

Researchers in the UK have demonstrated the use of Liquid Extraction Surface Analysis (LESA) on the TriVersa NanoMate for top-down identification of proteins directly from living bacterial colonies grown in Petri dishes, without sample preparation. The method offers “improved sampling precision and could be useful for spatial profiling of bacterial colonies or analysis of contaminated surfaces.”

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October 25, 2014

New Video: Direct Analysis of Liquids and Solids

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. Our new video demonstrates analysis of a reaction mixture.

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October 25, 2014

Environmental Analysis: Quantitation of Perchlorate by Ion Chromatography with Supressed Conductivity on the expression CMS

The expression Compact Mass Spectrometer (CMS) provides lower detection limits and greater selectivity for Perchlorate compared to a conductivity detector (CD).

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