December 9, 2014

Using the TriVersa NanoMate with LESA for Analyte Profiling in Material Science

Surface analysis techniques have gained significant attention over the last couple of years with LESA being an interesting alternative to techniques such as SIMS or MALDI imaging. A new application note demonstrates practical applications for LESA in the material sciences.

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December 9, 2014

LC/MS Determination of Amino Acids Using Compact Mass Spectrometry

See examples for the determination of amino acids on a combined HPLC compact mass spectrometry (LC/CMS) system for the rapid detection and quantification of amino acids utilizing a novel mixed mode LC column.

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December 9, 2014

“Essential for any Lipidomics Laboratory.”

Associate Professor Christer S. Ejsing at the University of Southern Denmark uses the TriVersa NanoMate, as an essential laboratory instrument, for the development and applications of Lipidomic technology.

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October 28, 2014

New publication: Direct analysis of intact proteins from Escherichia coli colonies by LESA mass spectrometry

Researchers in the UK have demonstrated the use of Liquid Extraction Surface Analysis (LESA) on the TriVersa NanoMate for top-down identification of proteins directly from living bacterial colonies grown in Petri dishes, without sample preparation. The method offers “improved sampling precision and could be useful for spatial profiling of bacterial colonies or analysis of contaminated surfaces.”

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October 25, 2014

New Video: Direct Analysis of Liquids and Solids

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. Our new video demonstrates analysis of a reaction mixture.

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October 25, 2014

Environmental Analysis: Quantitation of Perchlorate by Ion Chromatography with Supressed Conductivity on the expression CMS

The expression Compact Mass Spectrometer (CMS) provides lower detection limits and greater selectivity for Perchlorate compared to a conductivity detector (CD).

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October 20, 2014

“Anyone interested in volatiles will find the CMS is an excellent instrument for targeted analysis.”

Dr. James Reynolds’s group at the University of Loughborough conducts analysis of volatiles by direct breath analysis. The expression CMS allows for highly sensitive dermination of volatile species in breath with no preconcentration.

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September 23, 2014

Reaction Monitoring by Direct Analysis Probe on a Compact Mass Spectrometer

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP) permits fast analysis of solid and liquid samples and is a simple, faster and lower cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile compounds. ASAP is available as a combined ASAP-APCI source, or existing APCI sources can be easily modified to become dual APCI-ASAP capable.

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September 8, 2014

“Everyone can use it, including students.”

Dr. Frédéric Schmidt’s group at the Institut Curie in Paris had previously given their samples to outside MS services for analysis and had to wait for the results. Incorporating Advion’s expression CMS into their lab allowed them to have a self-service option that everyone could use. And the new workflow sped up their process significantly.

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August 20, 2014

Peptide/Protein Analysis in Less than One Minute

The expression CMS is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.

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August 19, 2014

Direct Mass Analysis from Solid & Liquid Samples

The expression CMS improves the chemist’s workflow by using a direct analysis probe, otherwise known as ASAP (Atomospheric Solids Analysis Probe), to permit chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.

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July 18, 2014

“The CMS is a rugged instrument.”

Dr. Albert Koulman, a Senior Investigative Scientist with MRC Human Nutrition Research, is developing methods to gather information about lipoproteins while looking at the lipid through online liquid/liquid extraction using the expression CMS as the detector.

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June 24, 2014

“The CMS is a very helpful instrument that has shorten product detection times.”

Professor Meng of the Beijing Institute of Technology uses mass spectrometry as a tool for synthetic intermediates. With a large number of products to run, Meng and his team needed to shorten product detection times.

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June 24, 2014

Determination of Emerging Nitrogenous Economic Adulterants in Milk Proteins by HPLC/Compact Mass Spectrometry

The ability to rapidly screen milk ingredients in the manufacturing plants for potential economic adulterants is becoming increasingly important.

A simpler and more cost-effective alternative for frontline screening has been developed.

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June 12, 2014

Utilizing a novel compact mass spectrometer (CMS) for the detection and quantification of chemical compounds related to cannabis

Regardless of the legal status of cannabis and its chemical compounds, both the quality control in legal markets as well as the law enforcement of it’s illegal status require simple, unequivocal and legally defendable analysis methods for the detection and quantification of its major chemical compounds.

Whenever a detector of high selectivity and sensitivity is required, a mass spectrometry based analysis workflow is usually the method of choice and we here demonstrate the analysis of delta9-Tetrahydrocannabinol (THC), Canabidiol (CBD) and Canabinol (CBN) utilizing a novel compact mass spectrometer (expression-S, Advion, NY) coupled to ultra-high performance liquid chromatography (UHPLC) or thin layer chromatography (TLC).

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June 12, 2014

On-Demand Webinar: HRMS, Chemical Modification and Liquid Extraction Surface Analysis for Lipidome Profiling of Colon Adenocarcinom

In this presentation, the development and application of a straightforward and high throughout analysis strategy consisting of high-resolution ‘shotgun’ mass spectrometry (MS), ‘targeted’ tandem mass spectrometry (MS/MS), functional group specific chemical modification and in situ liquid extraction of cell culture samples is described for the comprehensive identification, characterization and quantification of multiple lipid classes from within a colon adenocarcinoma cell line, SW480, and its metastasized derivative, SW620.

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June 2, 2014

Evaluation of a compact mass spectrometer for routine support of pharmaceutical chemistry

Bu X1, Yang J2, Gong X2, Welch CJ3

1Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
2Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
3Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA

The suitability of a recently introduced inexpensive, compact mass spectrometer detector is evaluated for supporting pharmaceutical chemistry investigations. While high performance/high cost MS detectors dominate the marketplace, there is growing recognition of the need for a small, inexpensive MS detector with reduced capabilities for supporting synthetic chemistry investigations, where reduced sensitivity and unit mass resolution are often suitable for solving routine problems. In this study, the fundamental performance characteristics of the recently introduced Advion compact mass spectrometer were evaluated, investigating the use of the instrument for routine product and impurity identification, reaction monitoring, evaluation of potential genotoxic impurities and study of high molecular weight biomolecules. In general, the results of the evaluation show this compact and inexpensive mass spectrometer to be well suited for providing reliable support for pharmaceutical chemistry investigations, with sub-nanogram limit of detection and impurity identification below 0.1% being possible in some instance.

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May 21, 2014

Latest Peer-Reviewed Publication

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

Lucie Guetzoyan,a Richard J. Ingham,a Nikzad Nikbin,a Julien Rossignol,a Michael Wolling,a Mark Baumert,b Nicola A. Burgess-Brown,c Claire M. Strain- Damerell,c Leela Shrestha,c Paul E. Brennan,c Oleg Fedorov,c Stefan Knappc and Steven V. Ley*a

aInnovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK.

bAdvion Ltd, Harlow Enterprise Hub, Edinburgh Way, Harlow, Essex, CM20 2NQ, UK cStructural Genomics Consortium and Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK

A combination of conventional organic synthesis, remotely monitored flow synthesis and bioassay platforms, were used for the evaluation of novel inhibitors targeting bromodomains outside the wellstudied bromodomain and extra terminal (BET) family, here exemplified by activity measurements on the bromodomain of BRD9 protein, a component of some tissue-specific SWi/SNF chromatin remodelling complexes. The Frontal Affinity Chromatography combined with Mass Spectrometry (FAC-MS) method proved to be reliable and results correlated well with an independent thermal shift assay.

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May 21, 2014

“I recommend the expression CMS to all laboratories that routinely synthesize new small molecules”

Prof. Dr. Nathan Luedtke and his group at the University of Zurich utilize the CMS to address unresolved questions in DNA chemical biology by developing molecular probes for characterizing structure, function and dynamics of nucleic acids in vivo.

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May 21, 2014

Electrospray LC/MS response differences from equimolar quantities of drugs using a CMS equipped with atmospheric pressure ionization

The results from this study shed some light on the relative merits of APCI vs ESI as well as the importance of the optimal ionization polarity for the LC/MS determination of the selected acidic and basic small molecule drugs.

Download the poster presentation »