NanoTek® Select References

The NanoTek accelerates rapid optimization of novel compounds, delivering increased reaction efficiency and reduced precursor usage.

SYNTHESIZED COMPOUNDS TO DATE

[18F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
Philippe, C et al.
Bioorg Med Chem. 2012 October 1; 20(19): 5936–5940

Rapid and Efficient Radiosyntheses of meta-Substituted [18F]Fluoroarenes from [18F]Fluoride Ion and Diaryliodonium ­Tosylates within a Microreactor
Chun JH, Lu S, Pike VW
DOI: 10.1002/ejoc.201100382

Syntheses of mGluR5 PET radioligands through the radiofluorination of diaryliodonium tosylates
Telu S, Chun JH, Siméon FG, Lu S, Pike VW
Org Biomol Chem. 2011 Oct 7;9(19):6629-38. Epub 2011 Aug 16

Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer
Kealey, S.; Plisson, C.; Collier, T. L.; Long, N. J.; Husbands, S. M.; Martarello, L.; Gee, A. D.
Org. Biomol. Chem., 2011. [Epub 25 March 2011]

Microfluidic preparation of [18F]FE@SUPPY and [18F]FE@SUPPY:2–comparison with conventional radiosyntheses
Ungersboeck J, Philippe C, Mien LK, Haeusler D, Shanab K, Lanzenberger R, Spreitzer H, Keppler BK, Dudczak R, Kletter K, Mitterhauser M, Wadsak W
Nucl Med Biol., 2011 Apr;38(3):427-34. Epub 2010 Dec 3

Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-d-arabinofuranosyl)-2-nitroimidazole using microfluidic technology
Bouvet, V. R.; Wuest, M.; Wiebe, L. I.; Wuest, F.
Nucl Med Biol., 2010 February, 38 (2):235-245. [Epub 3 December 2010]

Fast and high-yield microreactor syntheses of ortho-substituted [18F]fluoroarenes from reactions of [18F]fluoride ion with diaryliodonium salts
Chun, J.-H.; Lu, S.; Lee, Y.-S.; Pike, V. W.
J. Org. Chem., 2010, 75 (10):3332-3338.

Improved synthesis of 2′-deoxy-2′-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU)
Anderson, H.; Pillarsetty, N.; Cantorias, M.; Lewis, J.S.
Nucl Med Biol. 2010 May, 37(4):439-42.

Microfluidic approach for fast labeling optimization and dose-on-demand implementation
Pascali, G.; Mazzone, G.; Saccomanni, G.; Manera, C.; Salvadori, P. A.
Nuclear Medicine and Biology, 2010; 37:547-555.

A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
Palmieri, A.; Ley, S. V.; Hammond, K.; Polyzos, A.; Baxendale, I. R.
Tetrahedron Letters, 2009, 50 (26):3287-3289.

Single-step high-yield radiosynthesis and evaluation of a sensitive F-labeled ligand for imaging brain Peripheral benzodiazepine receptors with PET
Briard, E.; Zoghbi, S. S.; Simeon, F. G.; Imaizumi, M.; Gourley, H.; Shetty, H. U.; Lu, S.; Fujita, M.; Innis, R. B.; Pike, V. W.
J. Med. Chem., 2009 February 12, 52 (3):688-699.

Synthesis of [18F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies
Lu, S.; Giamis, A. M.; Pike, V. W.
Curr. Radiopharm., 2009;2(1):nihpa81093.