NanoTek® Select References

The NanoTek accelerates rapid optimization of novel compounds, delivering increased reaction efficiency and reduced precursor usage.

SYNTHESIZED COMPOUNDS TO DATE

Microfluidics in radiopharmaceutical chemistry
Giancarlo Pascalia, et al. Nuclear Medicine and Biology Volume 40, Issue 6, August 2013, Pages 776–787

Preparation of technetium-99m bifunctional chelate complexes using a microfluidic reactor: a comparative study with conventional and microwave labeling methods
Ryan W. Simms, et al. Journal of Labelled Compounds and Radiopharmaceuticals Volume 55, Issue 1, pages 18–22, January 2012

Radiolabeling of [18F]altanserin — a microfluidic approach
Johanna Ungersboecka, et al. Nuclear Medicine and Biology Volume 39, Issue 7, October 2012, Pages 1087–1092

Microfluidic technology: An economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET)
Vincent Bouvet, et al. Bioorganic & Medicinal Chemistry Letters Volume 22, Issue 6, 15 March 2012, Pages 2291–2295

A rapid microfluidic synthesis of [18F]fluoroarenes from nitroarenes
Thomas M. Moore, et al. Applied Radiation and Isotopes Volume 71, Issue 1, January 2013, Pages 47–50

Synthesis of 13N-labelled radiotracers by using microfluidic technology
Vijay Gaja, et al. Journal of Labelled Compounds and Radiopharmaceuticals Volume 55, Issue 9, pages 332–338, July 2012

Microfluidic Synthesis of 4-[18F]Fluorobenzaldehyde using Diaryliodonium Salts
Charlton, Michael Presented at COMPOUNDS & RADIOPHARMACEUTICALS, 2013 – ncl.ac.uk

Radiofluorination and reductive amination using a microfluidic device
Kenneth Dahl, et al. Journal of Labelled Compounds and Radiopharmaceuticals Volume 55, Issue 13, pages 455–459, November 2012

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds
Steven H. Liang, et al. Chem. Commun., 2013,49, 8755-8757 DOI: 10.1039/C3CC45166F

Synthesis of 4-[18F]Fluorobenzaldehyde using  Diaryliodonium Salt Precursors in a Microreactor
Michael Charlton presented at YRM 27/28th March 2012

Single-step radiofluorination of peptides using continuous flow microreactor
Svetlana V. Selivanova, et al. Org. Biomol. Chem., 2012,10, 3871-3874 DOI: 10.1039/C2OB00015F

Evaluation of tetraethylammonium bicarbonate as a phase-transfer agent in the formation of [18F]fluoroarenes
Christopher D. Reed, et al. Journal of Fluorine Chemistry Volume 143, November 2012, Pages 231–237

Single-Step Radiosynthesis of “18F-Labeled Click Synthons” from Azide-Functionalized Diaryliodonium Salts
Joong-Hyun Chun, Victor W. Pike European Journal of Organic Chemistry Volume 2012, Issue 24, pages 4541–4547, August 2012

18F-Labeled phosphopeptide-cell-penetrating peptide dimers with enhanced cell uptake properties in human cancer cells
Susan Richtera, et al. Nuclear Medicine and Biology Volume 39, Issue 8, November 2012, Pages 1202–1212

18F Labeling of Arenes
Matthew Tredwell, Véronique Gouverneur Angewandte Chemie International Edition Volume 51, Issue 46, pages 11426–11437, November 12, 2012

[18F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
Philippe, C et al.
Bioorg Med Chem. 2012 October 1; 20(19): 5936–5940

Rapid and Efficient Radiosyntheses of meta-Substituted [18F]Fluoroarenes from [18F]Fluoride Ion and Diaryliodonium ­Tosylates within a Microreactor
Chun JH, Lu S, Pike VW
DOI: 10.1002/ejoc.201100382

Syntheses of mGluR5 PET radioligands through the radiofluorination of diaryliodonium tosylates
Telu S, Chun JH, Siméon FG, Lu S, Pike VW
Org Biomol Chem. 2011 Oct 7;9(19):6629-38. Epub 2011 Aug 16

Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer
Kealey, S.; Plisson, C.; Collier, T. L.; Long, N. J.; Husbands, S. M.; Martarello, L.; Gee, A. D.
Org. Biomol. Chem., 2011. [Epub 25 March 2011]

Microfluidic preparation of [18F]FE@SUPPY and [18F]FE@SUPPY:2–comparison with conventional radiosyntheses
Ungersboeck J, Philippe C, Mien LK, Haeusler D, Shanab K, Lanzenberger R, Spreitzer H, Keppler BK, Dudczak R, Kletter K, Mitterhauser M, Wadsak W
Nucl Med Biol., 2011 Apr;38(3):427-34. Epub 2010 Dec 3

Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-d-arabinofuranosyl)-2-nitroimidazole using microfluidic technology
Bouvet, V. R.; Wuest, M.; Wiebe, L. I.; Wuest, F.
Nucl Med Biol., 2010 February, 38 (2):235-245. [Epub 3 December 2010]

Fast and high-yield microreactor syntheses of ortho-substituted [18F]fluoroarenes from reactions of [18F]fluoride ion with diaryliodonium salts
Chun, J.-H.; Lu, S.; Lee, Y.-S.; Pike, V. W.
J. Org. Chem., 2010, 75 (10):3332-3338.

Improved synthesis of 2′-deoxy-2′-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU)
Anderson, H.; Pillarsetty, N.; Cantorias, M.; Lewis, J.S.
Nucl Med Biol. 2010 May, 37(4):439-42.

Microfluidic approach for fast labeling optimization and dose-on-demand implementation
Pascali, G.; Mazzone, G.; Saccomanni, G.; Manera, C.; Salvadori, P. A.
Nuclear Medicine and Biology, 2010; 37:547-555.

A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
Palmieri, A.; Ley, S. V.; Hammond, K.; Polyzos, A.; Baxendale, I. R.
Tetrahedron Letters, 2009, 50 (26):3287-3289.

Single-step high-yield radiosynthesis and evaluation of a sensitive F-labeled ligand for imaging brain Peripheral benzodiazepine receptors with PET
Briard, E.; Zoghbi, S. S.; Simeon, F. G.; Imaizumi, M.; Gourley, H.; Shetty, H. U.; Lu, S.; Fujita, M.; Innis, R. B.; Pike, V. W.
J. Med. Chem., 2009 February 12, 52 (3):688-699.

Synthesis of [18F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies
Lu, S.; Giamis, A. M.; Pike, V. W.
Curr. Radiopharm., 2009;2(1):nihpa81093.