Advion BioSystems, Inc. and Waters Corporation Announce Compatibility of Advion’s TriVersa NanoMate® Chip-Based Nanoelectrospray System with Waters' Newest Range of Xevo™ and SYNAPT™ Mass Spectrometers

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BREMEN, Germany, August 31, 2009 — Advion BioSystems, Inc. (Advion) and Waters Corporation (NYSE:WAT) jointly announced today at the 18th International Mass Spectrometry Conference (IMSC) that Advion’s TriVersa NanoMate® chip-based nanoelectrospray ionization system is now compatible with the full range of Waters® mass spectrometry (MS) systems including the newest Xevo™ and SYNAPT™ G2 systems. The TriVersa NanoMate is an automated fraction collection and nanoelectrospray system that connects to the inlet of a mass spectrometer. It combines the benefits of micro or capillary-scale liquid chromatography (LC), with simultaneous fraction collection and subsequent chip-based infusion of the LC fractions in one system to increase the performance and automation of MS, allowing analysts to obtain more information from complex samples than with LC/MS alone.

Advion and Waters have collaborated to interface the TriVersa NanoMate to the latest high performance MS systems from Waters. These include Waters SYNAPT G2 MS, SYNAPT G2 High Definition Mass Spectrometry™ (HDMS™) platform, Xevo TQ MS, and Xevo QTof, a quadrupole time-of-flight (QTof) mass spectrometer.

“We are really excited about the combination of the TriVersa NanoMate with the latest Xevo and SYNAPT G2 instruments,” said Jack Henion, Advion’s Chief Scientific Officer. “The unique ability of the TriVersa to perform online LC/MS while collecting fractions for later infusion, coupled to the high resolution, exact mass TOF-MS systems from Waters provides a compelling, versatile tool for antibody analysis, proteomics, metabolite identification and profiling, metabolomics, natural products and many other chemical and biochemical analyses.”

Advion has also launched DualSpray™ which provides LockSpray™ capability when using the TriVersa NanoMate with the Waters QTof Premier™, QTof Micro™, SYNAPT MS and SYNAPT HDMS instruments. DualSpray provides a second nanoelectrospray to provide a reference ‘lock’ mass in the same way that Waters’ own LockSpray system does, under full control of the Waters MassLynx™ software.

Advion will begin shipments of DualSpray technology for the new Waters Xevo and SYNAPT G2 mass spectrometer product lines in December 2009.

For More Information

For additional product information on Advion’s TriVersa NanoMate and DualSpray technology, please visit

For more product information on Waters SYNAPT G2 mass spectrometers and Waters family of Xevo mass spectrometers, go to and, respectively.

About Advion BioSystems, Inc.
Advion is the scientific leader in microfluidic systems. The company’s scientific knowledge base creates unique nanotechnologies delivering speed, flexibility, and exceptional data quality. Advion is the microfluidics supplier of choice for customers demanding scientific excellence, more information from complex samples, and greater throughput. More about the company and how its technology is enhancing the power of mass spectrometry can be found at

About Waters Corporation (
Waters Corporation (NYSE:WAT) creates business advantage for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety and water quality worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.

With revenue of $1.58 billion in 2008 and 5,000 employees, Waters is driving scientific discovery and operational excellence for customers worldwide.

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Waters, Synapt, Xevo, QTof, High Definition MS, HDMS, MassLynx, QTof Premier, and QTof micro are trademarks of Waters Corporation.

Advion, Advion BioSystems, TriVersa NanoMate and DualSpray are trademarks of Advion BioSciences, Inc.

For Advion:
Heather Scollins
Sr. Marketing Communication Specialist
Advion BioSciences, Inc.
p: 1.607.266.0665 ext. 333