TriVersa NanoMate®

Nanoelectrospray ionization technology
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Nanoelectrospray ionization technology

TriVersa NanoMate<sup>®</sup>

The TriVersa NanoMate LESA® is the latest in chip-based electrospray ionization technology from Advion Interchim Scientific®. It combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform.

Obtain more information from complex samples than LC/MS alone

The TriVersa NanoMate® integrates with:

  • Advion Interchim Scientific® ESI Chip®
  • LC/MS with Fraction Collection for Re-Analysis by Infusion
  • Liquid Extraction Surface Analysis (LESA® and LESAplus)

Advion Interchim Scientific® ESI Chip®

The ESI Chip® unleashes the power of mass spectrometry through miniaturization. This microfluidics chip contains an array of 400 nano-electrospray nozzles, etched in a silicon wafer. The fabrication method is highly reproducible to ensure the integrity and equal performance of each nozzle. The electrical field created by the nano-electrospray nozzles results in a highly efficient ionization and long-lasting, stable spray from µL of sample volume.

    • ESI chips are available in three different nozzle emitter sizes from 2.5 µm to 5.5 µm ID
    • Internal chip void volume in the pL range allows for 15 min spray times from only 3 µL of sample
    • Automated sample handling can deliver spray from samples in 96 or 384 well plates
    • Silicon chip design delivers superior electric field strength and ionization efficiency
    • Internal counter electrode allows for spray sensing and recovery feature

Chip-based Direct Infusion and LC/MS Fraction Collection with Re-analysis by Infusion

The TriVersa NanoMate® is the only automated ion source platform that allows high throughput infusion experiments for small or large analytes in applications ranging from shotgun lipidomics and non-covalent interaction studies (NCI) to protein characterization.

The TriVersa NanoMate® was developed to operate as a nano-ESI ion source for LC/MS applications. Excess LC eluate can be utilized for additional fraction collection to create physical storage of the LC/MS experiment and allows re-analysis of fractions of interest as identified by the online LC/MS run.

Liquid Extraction Surface Analysis (LESA® and LESAplus)

LESA was developed in collaboration with Dr. Gary van Berkel from the Oak Ridge National Laboratories. Its unique surface extraction via a liquid droplet held in suspension (liquid junction) allows a novel approach for spatially resolved analysis of biological and technical surfaces of interest:

  • Fast, simple and direct analysis
  • 1 mm spatial resolution (LESA); 400 µm resolution (LESAplus)
  • Liquid extraction and nESI based analysis
  • High sensitivity due to nESI ionization and analyte extraction into only 1 µL of solvent
  • Optional nLC separation (LESAplus)


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