Resource Center

Learn how SpiroChem AG (Switzerland) utilized the Advion expression® Compact Mass Spectrometer (CMS) and Plate Express® TLC Plate Reader for reaction monitoring and compound identification to aide in accelerating drug discovery. Abstract: In highly competitive research environments, the ability to access more complex structural spaces efficiently is a predictor of a company’s ability to generate novel …

In this application note, both the purification and analytical processes for THC remediation using the Interchim ITM-5015 and Advion AVANT™ HPLC-UV systems are shown to form a complete solution for THC remediation in the hemp industry.

University of Cambridge, Royal Holloway University of London Highlights Combining FACS and LESA-MS to establish high-throughput single cell lipid profiling Lipid differences found within and between populations of human dopamine neurons Inter-cell lipid heterogeneity is increased in SNCA-A53T dopamine neurons Identification and isolation of human iPSC-dopamine neurons with a TH-RFP reporter Summary Advances in single …

Successfully completing an organic synthesis involves three typically lengthy, but crucial steps: reaction monitoring, compound identification, and purification. These steps can create bottlenecks in the synthesis, unless a purpose-built, streamlined, and reliable workflow is on hand. This whitepaper delves into some of the challenges faced by synthetic organic chemists as they navigate compound identification and …

University of Birmingham Abstract We have previously demonstrated native liquid extraction surface analysis (LESA) mass spectrometry imaging of small intact proteins in thin tissue sections. We also showed calculation of collision cross sections for specific proteins extracted from discrete locations in tissue by LESA traveling wave ion mobility spectrometry (TWIMS). Here, we demonstrate an integrated …

The compound synthesis, purification and confirmation processes often present challenges. From ensuring successful synthesis of your product, setting up a flash purification method, and finally confirming ID of fractions, the lengthy work flow can be time consuming and repetitive. This webinar will provide a foundation for flash purification processes, and will showcase a novel work …

University of North Texas, Huazhong Agricultural University, Heinrich Heine University, University of Goettingen, Leibniz Institute of Plant Genetics & Crop Plant Research, USDA-ARS Abstract Seeds of the desert shrub, jojoba (Simmondsia chinensis), are an abundant, renewable source of liquid wax esters, which are valued additives in cosmetic products and industrial lubricants. Jojoba is relegated to its …

Mass spectrometry is an analytical technique used to determine the mass-to-charge ratio of ions in a sample and therefore the sample composition. This method is used across many industries including food and beverage, environmental monitoring, and clinical. There are many features of mass spectrometers that must be considered before purchasing such as the required mass …

Environmental monitoring is vital to understanding the world around us. Air quality, water, and soil testing all provide valuable information about an environment’s status. Tools and technologies for environmental monitoring can be used to evaluate the sanitation of a food and beverage lab or to monitor an ecosystem’s recovery after an oil spill. Join Lab …

Lab Manager Tech Trends Webinar. Recorded June 25, 2020. Food and beverage labs use techniques from other disciplines such as microbiology, environmental monitoring, and analytical chemistry to test for food and beverage contaminants. Unlike these disciplines, the food and beverage industry is highly regulated and therefore food and beverage labs have very specific needs. Join …

This is one from a set of two application notes. In this application note, we determine the purity of collection of a small (0.2%) impurity in a concentrated sample mix by mass-directed fraction collection using supercritical fluid chromatography (SFC) coupled with the Advion expression Compact Mass Spectrometer (CMS). For the other application note on the …

A simple, sensitive and selective ASAP sample introduction approach to measuring the presence of two isobaric compounds, CBDA and THCA, contained in a complex sample such as hemp or cannabis plants or their corresponding extraction products. Measurements are made of differences in the relative composition of CBDA and THCA fragment ions originating from the same …

Review new data and tips for using the Advion SOLATION® inductively coupled plasma mass spectrometer (ICP-MS) in the cannabis and hemp testing lab, and factors that affect heavy metals in cannabis and hemp. This ebook was created with Spectroscopy and released June 2020.

Cecilie Rosting, Jinglei Yu, and Helen J. Cooper* Proof-of-concept results of coupled high field asymmetric waveform ion mobility spectrometry (FAIMS) with liquid chromatography–tandem mass spectrometry (LC–MS/MS) for nontargeted bottom-up proteomics of DBS with the aim of addressing these challenges are presented in this publication. Overall, this work demonstrates the benefits of inclusion of FAIMS for nontargeted proteomics of …

Abstract Liquid extraction surface analysis (LESA) is an ambient surface sampling technique that allows the analysis of intact proteins directly from tissue samples via mass spectrometry. Integration of ion mobility separation to LESA mass spectrometry workflows has shown significant improvements in the signal-to-noise ratios of the resulting protein mass spectra and hence the number of …

The combination of the Advion expression® CMS and Interchim puriFlash® flash chromatography technologies speed up the synthesis, purification and characterization of a compound. Using the Advion expression® Compact Mass Spectrometer, the Plate Express TLC Plate reader, the ASAP Atmospheric Solids Analysis Probe, and the Interchim puriFlash® XS520 flash purification system, it is now possible to execute a fast, user-friendly …

Mass spectrometric techniques are typically divided into two distinct fields: atomic and molecular. Liquid sampling – atmospheric pressure glow discharge (LS-APGD) has been developed as a versatile ionization source capable of combined atomic and molecular (CAM) analysis. To date, the LS-APGD has demonstrated impressive results in U isotope ratio analysis as well as molecular analysis across …

Dr. Jack Henion presents the possibility of using the Advion expression Compact Mass Spectrometer (CMS) for ‘roadside breath testing’ of THC DRUID (driving under the influence of drugs) with the use of a small plastic breath collection device from Breath Explor of Uppsala, Sweden. This device serves as a simple, acceptable collection device for individuals in …