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Abstract Stable isotope-resolved metabolomics (SIRM) can provide metabolic conversion information of specific targets; it is a powerful tool for cell metabolism studies. The common analytical platform for SIRM is chromatography-mass spectrometry, which requires a large number of cells and is not suitable for precious rare cell analysis. To study a small number of cells, we …

Abstract Investigation on the distribution of persistent organic pollutants (POPs) in aquatic organisms is of great importance for exploring the biological toxicity and health risks of environmental pollutants. In this study, a liquid extraction surface analysis mass spectrometry (LESA-MS) method was developed for rapid and in situ analysis of the spatial distribution of perfluoroalkyl substances …

Abstract Direct-infusion nanoelectrospray ionization high-resolution mass spectrometry (DI-nESI-HRMS) is an alternative approach to chromatography–MS-based techniques for nontargeted metabolomics, offering a high sample throughout. However, its annotation accuracy of analytes is still full of challenges. In this study, we proposed a strategy for the annotation and quantitation of nontargeted metabolomic data using a spectral-stitching DI-nESI-HRMS with …

Abstract Studies of cellular metabolism can provide profound insights into the underlying molecular mechanisms and metabolic function. To date, the majority of cellular metabolism studies based on chromatography–mass spectrometry (MS) require population cells to obtain informative metabolome. These methods are not only time-consuming but also not suitable for amount-limited cell samples such as circulating tumor …

Abstract Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are an important family of endogenous lipids, possessing antidiabetic and anti-inflammatory functions. Therefore, analysis of FAHFAs in biological samples obtained under healthy and disease states can uncover underlying mechanisms of various relevant disorders (e.g., diabetes and autoimmune diseases). Up to now, due to their extremely …

Abstract Introduction Agarwood is a highly valuable fragrant resinous wood which is widely used as traditional Chinese medicines, perfumes, incense and decorations. Due to its high economic value and excessive demand, this leads to a rising price and proliferation of fake commodities. Thus, strict authenticity identification and quality evaluation of agarwood are of great significance. …

Carbohydrates are non-chromophoric compounds which can often lead to flat signals when using UV detection only. In this application note, we show carbohydrate purification with ELSD and how such detection can help in purification. The ELSD detector that AIS proposes is capable of providing several benefits to the user, including: No need to define gain depending …

Available On Demand, Original Air-Date, February 12, 2025 from Lab Manager Coastal waters worldwide are contaminated with millions of metric tons of munitions from two world wars, posing significant risks to both ecosystems and human health. Traditional laboratory-based chemical methods for detecting munition compounds in seawater often require weeks or even months to process samples …

In this application note, we compare the use of a flash chromatography system with a UV detector alone versus the same system paired with a mass spectrometer. The data highlights the impact on workflow efficiency and underscores the importance of selecting the appropriate splitter. The specificity of MS detection improves the efficiency of the purification …

With any growing lab, scientists find an increasing list of needs to improve in throughput, capabilities, or just the addition of staff to your team. This can result in several outcomes that make it difficult to meet environmental and sustainability goals, or a laboratory’s bottom line. By building flexibility in your lab with multi-use instrumentation, …

In this application note, scientists from GEOMAR Helmholtz Centre for Ocean Research Kiel research residual TNT in the water phase from dumped weapons throughout the southwestern Baltic Sea. The Advion Interchim Scientific® expression® Compact Mass Spectrometer (CMS) is used for real-time sample detection of explosive chemicals released from these underwater relic munitions.

Genius Method Development Software: Your daily assistant for automated method transfer Recorded Thursday, October 24, 2024 With any system in the puriFlash® range, you will benefit from Genius, the artificial intelligence of the InterSoft® X software suggesting the best purification method for you based on your TLC and HPLC data. No matter how skillful you …

Product in Action Webinar Recorded Thursday, July 11, 2024, featured on LabManager.com Make your sample preparation process more reliable and secure. The SPE-LV6 is a fully automated positive pressure workstation for sample preparation by SPE solid phase extraction. Specially developed for all analytical chemists looking for performance and alternatives to manual use, the SPE-LV6 ensures …

Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart Abstract Mass spectrometry (MS) is introduced to high school students in the UK in many pre-university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their …

How it Works Webinar Please join us for an insightful webinar where we’ll focus our discussion on the qualitative analysis of oligonucleotides using the HPLC-UV/MS method. Discover how this approach can offer you purity analysis, and molecular weight determination through charge deconvolution, etc., and gain access to valuable tricks and tips for optimizing oligonucleotide analysis. …

This Webinar was originally presented March 7, 2024 on LabRoots.com ABSTRACT The latest purification systems are not like those of the past — you do not have to choose between flash and PrepLC. Now, you can have both with the ability to decide your needs with one user-friendly system. In this webinar, you will learn …

Jack Henion, Changtong Hao, Daniel Eikel, Olof Beck, and Peter Stambeck* Abstract Increased acceptance of cannabis containing the psychoactive component, Δ9-tetrahydrocannabinol (THC), raises concerns about the potential for impaired drivers and increased highway accidents. In contrast to the “breathalyzer” test, which is generally accepted for determining the alcohol level in a driver, there is no …

This Webinar was originally presented November 9, 2023 on LabRoots.com ABSTRACT In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover: How to select the ideal purification solution for your lab’s specific needs How …

This whitepaper explores the use of alternative chromatography technology for faster, more efficient analysis over traditional LC/MS runs. Plate Express™ is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, combined with the Advion Interchim Scientific® expression® CMS (Compact Mass Spectrometer) creating a technique known as TLC/CMS. Using …