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This is one from a set of two application notes. In this application note, we determine the purity of collection of a small (0.2%) impurity in a concentrated sample mix by mass-directed fraction collection using supercritical fluid chromatography (SFC) coupled with the Advion expression Compact Mass Spectrometer (CMS). For the other application note on the …

A simple, sensitive and selective ASAP sample introduction approach to measuring the presence of two isobaric compounds, CBDA and THCA, contained in a complex sample such as hemp or cannabis plants or their corresponding extraction products. Measurements are made of differences in the relative composition of CBDA and THCA fragment ions originating from the same …

Cecilie Rosting, Jinglei Yu, and Helen J. Cooper* Proof-of-concept results of coupled high field asymmetric waveform ion mobility spectrometry (FAIMS) with liquid chromatography–tandem mass spectrometry (LC–MS/MS) for nontargeted bottom-up proteomics of DBS with the aim of addressing these challenges are presented in this publication. Overall, this work demonstrates the benefits of inclusion of FAIMS for nontargeted proteomics of …

Abstract Liquid extraction surface analysis (LESA) is an ambient surface sampling technique that allows the analysis of intact proteins directly from tissue samples via mass spectrometry. Integration of ion mobility separation to LESA mass spectrometry workflows has shown significant improvements in the signal-to-noise ratios of the resulting protein mass spectra and hence the number of …

The combination of the Advion expression® CMS and Interchim puriFlash® flash chromatography technologies speed up the synthesis, purification and characterization of a compound. Using the Advion expression® Compact Mass Spectrometer, the Plate Express TLC Plate reader, the ASAP Atmospheric Solids Analysis Probe, and the Interchim puriFlash® XS520 flash purification system, it is now possible to execute a fast, user-friendly …

Mass spectrometric techniques are typically divided into two distinct fields: atomic and molecular. Liquid sampling – atmospheric pressure glow discharge (LS-APGD) has been developed as a versatile ionization source capable of combined atomic and molecular (CAM) analysis. To date, the LS-APGD has demonstrated impressive results in U isotope ratio analysis as well as molecular analysis across …

Dr. Jack Henion presents the possibility of using the Advion expression Compact Mass Spectrometer (CMS) for ‘roadside breath testing’ of THC DRUID (driving under the influence of drugs) with the use of a small plastic breath collection device from Breath Explor of Uppsala, Sweden. This device serves as a simple, acceptable collection device for individuals in …

Patulin is a mycotoxin that is a common contaminant in food and animal feed, especially in apple products. The potential health risk of patulin to humans led to the establishment of action levels in foodstuffs. The EU, WHO and US FDA defined maximum levels of patulin in fruit juices. The EU also has specific regulations …

Patulin is a mycotoxin that is a common contaminant in food and animal feed, especially in apple products. The potential health risk of patulin to humans led to the establishment of action levels in foodstuffs. The EU, WHO and US FDA defined maximum levels of patulin in fruit juices. The EU also has specific regulations for …

This application note covers the monitoring of intermediates formed during synthesis of fallypride by forming electrospray droplets with the expression Compact Mass Spectrometer (CMS). Recent studies have shown that reactions inside droplets can proceed at accelerated rates as compared to the macroscopic or flask reactions, especially when droplets are formed in the electrospray ion source. The …

The compound synthesis, purification and confirmation process often presents challenges throughout. From ensuring successful synthesis of your product, setting up a flash purification method, and finally confirming ID of fractions, the lengthy work flow can be time consuming and repetitive. In this application note, we demonstrate how the combination of Advion and Interchim technologies speed …

The combination of the Advion expression® CMS and Interchim puriFlash® flash chromatography technologies speed up the synthesis, purification and characterization of a compound. Watched the video and ready to learn more? View More TLC to Flash Details

This application note covers the monitoring of intermediates formed during the Pomeranz−Fritsch synthesis of isoquinoline by forming electrospray droplets with the expression Compact Mass Spectrometer (CMS). Recent studies have shown that reactions inside droplets can proceed at accelerated rates as compared to the macroscopic or flask reactions, especially when droplets are formed in the electrospray …

In this application note, the Advion expression Compact Mass Spectrometer (CMS) with volatile APCI (vAPCI) is used to analyze volatile compounds present during the fermentation of homebrewed beer by Stephanie Rankin Turner of Loughborough University. The complex flavor of beer is primarily a result of the ingredients used, the brewing method, and conditions during fermentation. The …

Inductively coupled plasma mass spectrometry (ICP-MS) is a preferred method for heavy metal analysis of cannabis as the legalization of cannabis continues to grow in the United States. This application note presents the analysis of two hemp plants for toxic heavy metals using the Advion SOLATION® ICP-MS. In this application note you will learn: How …

Learn Mass Spectrometry: For a limited time, access our free curriculum from Dr. Jack Henion, global leader and educator for Mass Spectrometry and LC/MS Take advantage of this educational opportunity to learn from the master, Dr. Henion, Cornell Emeritus Professor, who will guide you through basic principles to more advanced techniques. This lecture series offers a …

The Advion x Interchim suite of systems and consumables allows users to harness the power of mass spectrometry, flash chromatography, prep LC and more. Simple and robust, download our brochure to learn more about: The Advion expression compact mass spectrometer (CMS): A fast and easy analytical tool for the organic chemist. Ideal for fast reaction monitoring, …

The brain is a remarkably complex organ and cholesterol homeostasis underpins brain function. It is known that cholesterol is not evenly distributed across different brain regions; however, the precise map of cholesterol metabolism in the brain remains unclear. If cholesterol metabolism is to be correlated with brain function it is essential to generate such a …

The recent out break of sever lung injury is allegedly tied to the presence of Vitamin E Acetate (VEA) in vaping-related products after VEA was found in lung fluid samples of patients with vaping-related lung illness (EVALI). Calling for regulatory control, Washington, Colorado and Ohio have already banned the use of VEA in e-juices at the …

Learn how the expression Compact Mass Spectrometer can be used for fast screenings or robust LC/CMS runs – both in the lab and in the field – in this informative webinar session with Dr. Daniel Eikel, Advion Director of Product Applications.