Advion Offers Validated Methods for Methotrexate and 7-Hydroxymethotrexate

December 11, 2006 – Advion BioServices, a specialist in method development and validation of proprietary methods, also has a variety of validated non-proprietary LC/MS/MS methods available including the analysis of Methotrexate and 7-Hydroxymethotrexate to support clinical studies.

Methotrexate was originally developed to aid in the treatment of cancer, but has since been found to help treat several autoimmune diseases including psoriasis and rheumatoid arthritis. While Methotrexate is a commonly prescribed and used drug, Advion is one of the few bioanalytical laboratories which has a validated LC/MS/MS method for both Methotrexate and the 7-Hydroxymethotrexate metabolite. The Advion assays use solid-phase extraction to isolate the analytes and stable-labeled standards are available for both metabolites .The Advion assays are established for analysis of human plasma, urine and plasma samples.

Non-proprietary established validated methods offer a cost-effective and timely solution for clients with drug-drug interaction (DDI) or comparison studies with established therapeutic compounds. Advion is happy to partner with new and existing customers to develop non-proprietary assays which have value to the pharmaceutical industry.
For a complete list of Advion’s non-proprietary list of validated assay visit here