Combined Atomic and Molecular (CAM) Ionization: The Diversity of the Liquid Sampling – Atmospheric Pressure Glow Discharge

Authors: Tyler Williams¹, Jacob R. Bills¹, Jamey Jones², and R. Kenneth Marcus^1
1Clemson University, Department of Chemistry, Clemson, SC 29634
²Advion Inc, Ithaca, NY 14850

Mass spectrometric techniques are typically divided into two distinct fields: atomic and molecular. Liquid sampling – atmospheric pressure glow discharge (LS-APGD) has been developed as a versatile ionization source capable of combined atomic and molecular (CAM) analysis. To date, the LS-APGD has demonstrated impressive results in U isotope ratio analysis as well as molecular analysis across a wide range of instrument platforms.1-3 While molecular sampling has been demonstrated on this source, these samples fall into the realm of ESI-type samples, larger, polar compounds, most commonly LC-relevant drug targets. Presented here will be the demonstration of the wider versatility of the LS-APGD as a CAM ionization source using the Advion expression Compact Mass Spectrometer (CMS).

This poster was presented at the ASMS 2020 Reboot.

This research was also published in the Journal of Analytical Atomic Spectrometry (JAAS)*.
*This article is not open access.