Application Note
Analysis of 4-Aminobiphenyl and 4-Bromoanilin on normal phase TLC using TLC/MS
![Analysis of 4-Aminobiphenyl and 4-Bromoanilin on normal phase TLC using TLC/MS](https://www.advion.com/wp-content/uploads/Advion-Merck-CMS-PE-Aminobiphenyl-Normal-Phase-App-Note-cover.png)
The analytical verification of compounds in organic syntheses is a challenging task. The sample is often directly taken out of the reaction mixture and therefore contains many impurities and matrix components. As a result, low-level sample preparation combined with a direct analysis method is highly beneficial. TLC/MS (thin layer chromatography – mass spectrometry) is such an analytical technique.
Co-authored with Merck Millipore in Darmstadt, Germany, this application note demonstrates a normal phase TLC/CMS technique for the rapid determination of 4-aminobiphenyl in its reaction mixture.
For the application note on the TLC/CMS determination of 4-aminobiphenyl in reverse phase, click here.