Analysis of Iohexol using the Advion Interchim Scientific^® AVANT™ HPLC and expression^® CMS System

Iohexol is a widely used non-ionic imaging agent that improves contrast for x–ray analysis. Its low osmolality allows for a rapid clearance via the kidney, preventing reabsorption and further metabolization. This makes iohexol a compound with a better safety profile compared to other imaging agents.

In this application note, a simple and accurate HPLC-CMS method for iohexol analysis is introduced.