Qualitative Analysis of Oligonucleotides Using The Advion Interchim Scientific^® HPLC-UV/MS System

Oligonucleotides have gained significant attention in biopharmaceutical development due to their ability to modulate gene or protein expression. This application note aims to demonstrate the HPLC/UV analysis of multiple oligo samples and utilize HPLC/CMS analysis to determine their molecular weight.