Combined Atomic and Molecular (CAM) Ionization: The Diversity of the Liquid Sampling – Atmospheric Pressure Glow Discharge (LS-APGD) on a Compact Mass Spectrometer


Mass spectrometric techniques are typically divided into two distinct fields: atomic and molecular. Liquid sampling – atmospheric pressure glow discharge (LS-APGD) has been developed as a versatile ionization source capable of combined atomic and molecular (CAM) analysis. To date, the LS-APGD has demonstrated impressive results in U isotope ratio analysis as well as molecular analysis across a wide range of instrument platforms.1-3 While molecular sampling has been demonstrated on this source, these samples fall into the realm of ESI-type samples, larger, polar compounds, most commonly LC-relevant drug targets. Presented here will be the demonstration of the wider versatility of the LS-APGD as a CAM ionization source using the Advion expression Compact Mass Spectrometer (CMS).

Authors: Tyler Williams1, Jacob R. Bills1, Jamey Jones2, and R. Kenneth Marcus1
1Clemson University, Department of Chemistry, Clemson, SC 29634
2Advion Inc, Ithaca, NY 14850

This poster was presented at the ASMS 2020 Reboot.