Rapid Screening for Fentanyl in Urine Using a Compact Mass Spectrometer (CMS) with an Open Port Sampling Interface (OPSI)

Introduction

Fentanyl, a fast-acting synthetic painkiller about 100 times stronger than morphine, is also the most widely used synthetic opioid medicine in 2017.1 Its abuse is becoming a public health problem. A quick and easy analysis method for this drug is in high demand from health practitioners and law enforcement agencies.

The Touch Express^™ Open Port Sampling Interface (OPSI),2,3 is designed for simple sampling of solids, liquids, sample preparation tips and fibers. Paired with the ESI of the expression^® CMS, the product incorporates an open port of continuous low-volume solvent, flowing directly into the ESI for MS analysis. Any soluble sample touching the open port will be analyzed by the mass spectrometer in just seconds.

Here, a simple and quick analysis method for fentanyl in urine using Touch Express^™ OPSI on the Advion expression^® CMS is presented.