Higher purity. Higher Yield. Optimize your purification workflow, from lab scale to scale-up.

This Webinar was originally presented November 9, 2023 on LabRoots.com

In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover:

  • How to select the ideal purification solution for your lab’s specific needs
  • How to optimize your purification workflow daily, to automate compound ID and fraction confirmation – using simple, prep free tools
  • How your cell phone can be used for automated method development
  • How column selection factors in to your workflow, and why exploring what is best for your method matters

Chase Needham, puriFlash and PrepLC Applications Scientist, Advion Interchim Scientific®

A Handheld Guide: Fun & Easy Mass Spectrometry Experiments for your Teaching Lab

A book of experiments for your students

The expression® CMS (Compact Mass Spectrometer) is the ideal instrument for the teaching lab thanks to its small size, ease of use, and one-click software. This pocket guide of classroom experiments offers students the ability to gain hands-on instrument experience by eliminating complex and difficult sample preparation.

Streamlined Benchtop Chemistry: Faster Workflow from Reaction to Fraction

Lab Manager Ask the Expert Webinar. Recorded September 7, 2022

Maximize your workflow—even with limited space at the bench. This webinar features innovative solutions for streamlining the chemists’ everyday needs, including reaction monitoring, purification, fraction collection, and evaporation. No matter what your application, the session will address some of the most common bottlenecks and how to avoid them to improve your process.

As a viewer, you will learn more about:

  • How to use TLC plates to make flash purification faster and more efficient
  • Software hacks leveraging sophisticated algorithms for better purifications
  • 30-second fraction ID to speed up the process
  • How evaporation can be easier, faster, and more reliable

Webinar speakers include:

Gary Williams
Vice President, Chemist & North American Sales
Advion Interchim Scientific

Nathaniel Kunzer
Product Specialist

Helium Shortages in the Chemistry Lab: Compound Characterization Using Helium-Free Techniques

Helium shortages are not new – annually, scientists see the cost of helium rise and fall like the stock market. Except this isn’t just a financial impact. Global helium shortages threaten to derail research and essential industry functions, taking down GC and high-field NMR instruments, bringing a once state-of-the-art lab down to a bare-bones facility.

This whitepaper explores the use of alternative reaction monitoring technology, including the expression® CMS (Compact Mass Spectrometer), Plate ExpressTM TLC Plate Reader, and ASAP® probe for liquid and solid samples – all helium-free alternatives for the chemistry laboratory.

Reaction Monitoring Capabilities at the Bench:

  • The expression® CMS offers an ideal reaction monitoring solution that will live on long beyond the helium shortage and become a centerpiece of the lab. The system offers a complete solution for: 
  • Batch and flow chemistry 
  • Fast compound identification and purity determination
  • …with little or no sample preparation required, and many novel sample introduction interfaces

University of Oxford, Chemistry Teaching Laboratories

Q: What is the focus of your lab’s research?

A: We run a large and very busy Teaching Laboratory, teaching practical skills to almost 600 undergraduates on the MChem degree course at Oxford University.

Q: What are your previous workflow and experiences challenges?

A: In many universities, undergraduate access to mass spectrometry is limited to the occasional use of a service machine, whose primary role is to support the research groups in the department. Undergraduates might be provided with data from such a service but rarely are able to collect this data themselves.

Q: Why did you incorporate the expression® CMS?

A: The expression® CMS is a fantastic instrument for undergraduate teaching. We have two machines – one set up for TLC/MS and the other with an ASAP® probe. Undergraduates, right from the first year, experience how easy it is to gather high quality, mass spectrometry data. With limited training, students are able to use the spectrometers themselves, with minimal risk of instrument damage. Collecting MS data is now as routine as getting an IR spectrum and the fast throughput of samples allows many students a day to collect data.

Q: Who would you recommend to purchase the expression® CMS?

A: We would recommend any undergraduate teaching lab to consider the purchase of the expression® CMS system. We have had our machines for 3-4 years now, and the reliability has been very good indeed. The quality of the data obtained sets our students up to use mass spectrometry in their future research careers.

Q: Do you have any publications or presentations using the expression® CMS?

A: Poster presentation: The Use of Mass Spectrometry in an Integrated Undergraduate Practical Course. Presented at the chemistry and physics education conference, ViCEPhEC, in 2019.

We are currently working on a paper with Professor Claire Vallance on the use of machine learning to classify food stuffs (fruit, tea, whisky, etc.) by mass spectrometry as an undergraduate project. We intend to publish this work in the Journal of Chemical Education in the coming months.

Setting Up Flash Chromatography in Your Lab: Faster Workflows for Better Purifications

Avoid workflow bottlenecks by streamlining the flash purification process in your lab. This whitepaper can help you identify, reduce, or even eliminate these bottlenecks, tanking your standard operational time from hours to minutes. Learn how essential tools including TLC, a smartphone application and a simple dipping probe for fraction ID offer a novel, systematic approach to help accelerate both synthesis and purification.

Key Objectives:
  • Learn the key tools to setting up a streamlined purification workflow in your lab.
  • Review the most time-consuming processes in a routine flash purification workflow and how to avoid these bottlenecks.
  • Explore how modern technology, including a smartphone application, can assist with method development.

Mass Spec Simplified – Techniques for Reducing Sample Preparation Burden

This webinar features several useful tools to simplify or even eliminate the sample preparation involved prior to mass spectrometry. In this educational session you will learn about several prep-free mass spec techniques that are available, and how to select which method is best for your analysis. Advion will share their perspectives on some of the new tools and protocols to minimize and simplify sample preparation. You’ll learn how to reduce your time in the lab and see your mass spec results in as little as 30 seconds!

As an attendee, you will learn more about:

  • How to select the best tools for sample introduction based on your compound
  • How new tools can reduce or eliminate sample preparation for results in <30 seconds
  • New workflows to maximize your time in the lab by simplifying complex processes

This webinar was presented at the 2023 LabXpo Virtual event by Lab Manager  and LabX, recorded July 20, 2023.

Polymer Defect Engineering – Conductive 2D Organic Platelets from Precise Thiophene-Doped Polyethylene

Authors: Max Planck Institute for Polymer Research, Germany; University of Twente, Netherlands


We developed a simple way to create 2D conductive nanostructures with dielectric cores and conductive surfaces based on polyethylene with in-chain thiophene groups. Generally, thiophene-based polymers show great conductive properties, but exhibit a poor processability. Here, we use the crystallization of a polyethylene chain with precisely distributed thiophene groups as the platform for a self-organization of a lamellar structure. During crystallization, thiophene groups are expelled to the crystal surface. Subsequent copolymerization with 3,4-ethylenedioxythiophene (EDOT) molecules finally yields 2D platelets with a conductive surface. The electric properties of the surface are demonstrated by conductivity measurements. Given the molecular structure of the polymer, it can be assumed that the conductive layer consists of only one monoatomic layer of polymerized thiophene. We thus show a new way to create an ultra-thin, conductive surface on a polymer surface in just a few steps. Hence, the method presented here opens up a wide range of possibilities to produce complex, nanoscale electronic structures for microelectronic applications.

Mass spectrum analysis was obtained by ASAP/CMS using the Advion Interchim Scientific® ASAP® Atmospheric Solids Analysis Probe and expression® Compact Mass Spectrometer (CMS)