Efficient Reaction Monitoring with Advion Interchim Scientific ASAP-CMS for Compounds Requiring Polarity Switching in Medicinal Chemistry

This application note demonstrates the utility of the Advion Interchim Scientific® ASAP-CMS for efficient reaction monitoring of compounds requiring polarity switching – a common challenge in medicinal chemistry workflows. By enabling rapid switching between positive and negative ion modes without the need for complex sample preparation, the ASAP-CMS provides medicinal chemists with a streamlined, real-time solution for reaction tracking and decision making.

Testing Explosives and Narcotics Detection Performance on a Novel Ambient Desorption Ionization Compact Single Quadrupole Mass Spectrometer

In environments where safety can’t be compromised—airports, high-risk facilities, and our communities—reliably detecting explosives and narcotics is essential. Current trace detection systems, which rely on thermal desorption for sample introduction struggle with low-volatility substances like inorganic salts. Moreover, detection by retention time can also misidentify harmless materials, slowing down response times and eroding trust. That gap in speed and certainty puts people at risk—and demands a better solution.

This poster was presented at ASMS 2025 in Baltimore, MD, USA.

Enhanced Mass Spectrometry Detection of Organic Explosives Using Ambient Desorption/Ionization and Adducting Agents

Mass spectrometry detects chemicals based on their mass-to-charge ratio (m/z) in the gas phase after ionization from solid or liquid states. Ambient desorption/ionization (ADI), based on electrospray ionization (ESI), enhances detection through adduct formation, particularly for compounds that do not easily lose or gain protons. Monitoring adduct ions improves detection sensitivity and is preferred for identifying organic such as RDX, which are difficult to detect via deprotonation or protonation. Common adducts such as nitrate, acetate, or chloride have limitations in mass spectrometry due to their m/z overlapping with low-mass solvent contaminants. This study explores a novel adducting agent to improve organic explosive detection, increasing confidence in identification and sensitivity.

This poster was presented at ASMS 2025 in Baltimore, MD, USA.

Webinar: Below Deck – Real-time Detection of TNT in the Aarhus Bay from Dumped Weapons

Available On Demand, Original Air-Date, February 12, 2025 from Lab Manager

Coastal waters worldwide are contaminated with millions of metric tons of munitions from two world wars, posing significant risks to both ecosystems and human health. Traditional laboratory-based chemical methods for detecting munition compounds in seawater often require weeks or even months to process samples from collection to analysis.

As an attendee, you will learn more about:

  • How real-time analysis can be performed utilizing novel sample collection and introduction paired with portable compact mass spectrometry
  • Techniques to reduce errors, time, and labor involved in environmental sampling and analysis
  • How operating a laboratory on a ship impacts workflow, from sample collection to analysis

Speaker: Aaron Beck, Ph.D.
Senior Scientist, GEOMAR
Helmholtz Centre for Ocean Research, Kiel, Germany

Mass Directed Fraction Collection by Reverse Phase Flash Chromatography Coupled to the expression CMS

In this application note, we compare the use of a flash chromatography system with a UV detector alone versus the same system paired with a mass spectrometer. The data highlights the impact on workflow efficiency and underscores the importance of selecting the appropriate splitter.

The specificity of MS detection improves the efficiency of the purification workflow (compared to traditional Flash and HPLC).

Real-Time Detection of Munition Compounds (TNT) on the Sea

In this application note, scientists from GEOMAR Helmholtz Centre for Ocean Research Kiel research residual TNT in the water phase from dumped weapons throughout the southwestern Baltic Sea. The Advion Interchim Scientific® expression® Compact Mass Spectrometer (CMS) is used for real-time sample detection of explosive chemicals released from these underwater relic munitions.

The Power of Precision: Navigating Qualitative Oligonucleotide Analysis with HPLC-UV/MS

How it Works Webinar

Please join us for an insightful webinar where we’ll focus our discussion on the qualitative analysis of oligonucleotides using the HPLC-UV/MS method. Discover how this approach can offer you purity analysis, and molecular weight determination through charge deconvolution, etc., and gain access to valuable tricks and tips for optimizing oligonucleotide analysis. Additionally, learn how a streamlined method can provide both UV and MS analysis in a single run.

Speaker:
Changtong Hao
Senior Applications Scientist
Advion Interchim Scientific®

Higher purity. Higher Yield. Optimize your purification workflow, from lab scale to scale-up.

This Webinar was originally presented November 9, 2023 on LabRoots.com

ABSTRACT
In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover:

  • How to select the ideal purification solution for your lab’s specific needs
  • How to optimize your purification workflow daily, to automate compound ID and fraction confirmation – using simple, prep free tools
  • How your cell phone can be used for automated method development
  • How column selection factors in to your workflow, and why exploring what is best for your method matters

SPEAKER
Chase Needham, puriFlash and PrepLC Applications Scientist, Advion Interchim Scientific®