A diagnostic test for cocaine and benzoylecgonine in urine and oral fluid using portable mass spectrometry


University of Surrey, Surrey and Borders Partnership NHS Foundation Trust, Advion, Ltd.


Surface mass spectrometry methods can be difficult to use effectively with low cost, portable mass spectrometers. A new analytical method is presented where analytes are extracted from a sample using a solvent flushed across the surface under high pressure, separated using a chromatography column and then analysed using the Advion expression Compact Mass Spectrometer (CMS). In this publication, we demonstrate the efficacy of the method for the quantitative detection of cocaine and benzoylecgonine in urine and oral fluid.