Application of open port sampling interface mass spectrometry (OPSI‐MS) to deuterium exchange as an aid for structural elucidation


AstraZeneca, United Kingdom


Deuterium exchange has been demonstrated to provide additional information to accurate mass measurement and collision‐induced dissociation on unknown chemical structures. An enhanced method for rapid deuterium exchange could make this technique more routine for structural elucidation. Open port sampling interface mass spectrometry (OPSI‐MS) with an aprotic solvent offers a rapid method for performing deuterium incorporation.

Schematic of OPSI

This publication features the Advion Interchim Scientific® Touch Express OPSI with the expression® Compact Mass Spectrometer (CMS).