Distinguishing Patients with Idiopathic Epilepsy from Solitary Cysticercus Granuloma Epilepsy and Biochemical Phenotype Assessment using a Serum Biomolecule Profiling Platform


University of Oklahoma Health Sciences Center, Christian Medical College, Veterans Administration Medical Center, University of Montreal


A major source of epilepsy is Neurocysticercosis (NCC), caused by Taenia solium infection. Solitary cysticercus granuloma (SCG), a sub-group of NCC induced epilepsy, is the most common form of NCC in India. Current diagnostic criteria for SCG epilepsy require brain imaging which may not be available in communities where the disease is endemic. Identification of serum changes and potential biomolecules that could distinguish SCG epilepsy from idiopathic generalized epilepsy (IE), without the initial need for imaging, could assist in disease identification, understanding, and treatment. The objective here was to investigate, using mass spectrometry (MS), sera biomolecule differences between patients with SCG epilepsy or IE to help distinguish these disorders based on physiological differences, to understand underlying phenotypes and mechanisms, and to lay ground work for future therapeutic and biomarker analyses.

Analysis was performed by ESI ionization using the Advion expression Compact Mass Spectrometer (CMS).