Trimethylamine N-oxide, Mediterranean Diet, and Nutrition in Healthy, Normal-Weight Adults: Also a Matter of Sex?


Federico II University Medical School of Naples, University of Naples “Federico II”, Institute for Hospitalization and Healthcare SDN


Objective. Sex exerts an important influence on food preferences. The Mediterranean diet (MD) is based on the common dietary characteristics and lifestyle behaviors of the Mediterranean countries. Trimethylamine N-oxide (TMAO), a marker of gut dysbiosis linked to the development of atherosclerosis and cardiovascular risk, is mainly dependent on dietary pattern and gut microbiota metabolism. The aim of this study was to evaluate the association between levels of TMAO and adherence to the MD as a function of sex.