Tyrosinase Inhibitory Effect of (E)-2-(substituted benzylidene)-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one Derivatives


Eun Kyeong Lee, Ju Hyun Kim, Kyoung Mi Moon, Sugyeong Ha, Sang-Gyun Noh, Dae Hyun Kim, Bonggi Lee, Do Hyun Kim, Su Jeong Kim, Sultan Ullah, Hyung Ryong Moon, Hae Young Chung

The inhibition of tyrosinase, a key enzyme in mammalian melanin synthesis, plays an important role in preventing skin pigmentation and melanoma. Therefore, tyrosinase inhibitors are very important in the fields of medicine and cosmetics. However, only a few tyrosinase inhibitors are currently available because of their toxic effects on skin or lack of selectivity and stability. Therefore, we synthesized a novel series of (E)-2-(substituted benzylidene)-2,3-dihydro-1H-cyclopenta[a]naphthalen-1-one derivatives and evaluated their inhibitory effects on mushroom tyrosinase, with the aim of discovering a novel tyrosinase inhibitor. Among 19 derivatives, MHY3655 ($IC_{50}

The MS analysis was carried out using Advion Expression® CMS.