Higher purity. Higher Yield. Optimize your purification workflow, from lab scale to scale-up.

This Webinar was originally presented November 9, 2023 on LabRoots.com

In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover:

  • How to select the ideal purification solution for your lab’s specific needs
  • How to optimize your purification workflow daily, to automate compound ID and fraction confirmation – using simple, prep free tools
  • How your cell phone can be used for automated method development
  • How column selection factors in to your workflow, and why exploring what is best for your method matters

Chase Needham, puriFlash and PrepLC Applications Scientist, Advion Interchim Scientific®

Mass Spectrometry for Teaching Chemistry Undergraduates – The expression® CMS & the SOLATION® ICP-MS

Recorded November 3, 2022: Featured talk in the LCGC Mass Spectrometry Symposium

Join Fadi Abou-Shakra, Director of ICP-MS Portfolio for Advion Interchim Scientific®, as he shares some of the organization’s latest mass spectrometry applications for the teaching lab. This includes student-friendly experiments using a compact single-quadrupole system, as well as simplified ICP-MS applications.

Fadi Abou-shakra started using ICP-MS in 1987 applying it for the analysis of trace elements in biological fluids and has been active in the field of atomic spectroscopy since then. He holds an MSc in Medical Physics and a PhD in Chemistry from the University of Surrey, England. He brings a wealth of experience in ICP-MS as a researcher, customer support specialist and a business manager.

Ready to learn more?

Analytical Sciences Synthesis & Purification: Consumables, Reagents & Instruments

The new edition of our “Analytical Sciences, Synthesis & Purification” catalog is available now! Offering a full suite of innovative products and technologies from Advion Interchim Scientific, this catalog features over 20,000 products ranging from consumables and reagents to instrumentation.

Not only a product resource, the catalog features in-depth scientific information to improve your daily workflow, including sample preparation tips and tricks, analysis technologies such as GC and LC/MS, and help selecting the best consumables for your workflow or purification.

Take advantage of this extensive guide to boost your lab with:

  • 20,000 Products
  • 12 Chapters
  • Technicals Tips
  • New Systems

Laboratory Insider: A Look Inside the Organic Synthesis Lab

Ask the Expert Webinar
Presented live November 2, 2022

Step inside the Parasram Lab at New York University for a look at some of their latest research.

In this webinar, Professor Marvin Parasram will discuss data from his laboratory’s recent publication, “Anaerobic Heteroatom Transfer Reactions Using Photoexcited Nitroarenes.” The research features developments on the anaerobic cleavage of alkenes into carbonyl compounds using nitroarenes as oxygen transfer reagents under visible light. This approach is a safe and practical alternative to mainstream oxidative cleavage protocols, such as ozonolysis and the Lemieux–Johnson reaction.

As an attendee, you will learn more about:

  • How a wide range of alkenes possessing oxidatively sensitive functionalities underwent anaerobic cleavage to generate carbonyl derivatives with high efficiency and regioselectivity, using the Advion Interchim Scientific puriFlash® 5.250 Preparative HPLC system.
  • Mechanistic studies support that the transformation occurs via direct photoexcitation of the nitroarene followed by a nonstereospecific radical cycloaddition event with alkenes.
    How this process leads to 1,3,2- and 1,4,2-dioxazolidine intermediates that fragment to give the carbonyl products, using the Advion Interchim Scientific expression Compact Mass Spectrometer.
  • How a combination of radical clock experiments and in situ photoNMR spectroscopy revealed the identities of the key radical species and the putative aryl dioxazolidine intermediates, respectively.Watched the video and ready to learn more?

Streamlined Benchtop Chemistry: Faster Workflow from Reaction to Fraction

Lab Manager Ask the Expert Webinar. Recorded September 7, 2022

Maximize your workflow—even with limited space at the bench. This webinar features innovative solutions for streamlining the chemists’ everyday needs, including reaction monitoring, purification, fraction collection, and evaporation. No matter what your application, the session will address some of the most common bottlenecks and how to avoid them to improve your process.

As a viewer, you will learn more about:

  • How to use TLC plates to make flash purification faster and more efficient
  • Software hacks leveraging sophisticated algorithms for better purifications
  • 30-second fraction ID to speed up the process
  • How evaporation can be easier, faster, and more reliable

Webinar speakers include:

Gary Williams
Vice President, Chemist & North American Sales
Advion Interchim Scientific

Nathaniel Kunzer
Product Specialist

Helium Shortages in the Chemistry Lab: Compound Characterization Using Helium-Free Techniques

Helium shortages are not new – annually, scientists see the cost of helium rise and fall like the stock market. Except this isn’t just a financial impact. Global helium shortages threaten to derail research and essential industry functions, taking down GC and high-field NMR instruments, bringing a once state-of-the-art lab down to a bare-bones facility.

This whitepaper explores the use of alternative reaction monitoring technology, including the expression® CMS (Compact Mass Spectrometer), Plate ExpressTM TLC Plate Reader, and ASAP® probe for liquid and solid samples – all helium-free alternatives for the chemistry laboratory.

Reaction Monitoring Capabilities at the Bench:

  • The expression® CMS offers an ideal reaction monitoring solution that will live on long beyond the helium shortage and become a centerpiece of the lab. The system offers a complete solution for: 
  • Batch and flow chemistry 
  • Fast compound identification and purity determination
  • …with little or no sample preparation required, and many novel sample introduction interfaces

Mass Spec Simplified – Techniques for Reducing Sample Preparation Burden

This webinar features several useful tools to simplify or even eliminate the sample preparation involved prior to mass spectrometry. In this educational session you will learn about several prep-free mass spec techniques that are available, and how to select which method is best for your analysis. Advion will share their perspectives on some of the new tools and protocols to minimize and simplify sample preparation. You’ll learn how to reduce your time in the lab and see your mass spec results in as little as 30 seconds!

As an attendee, you will learn more about:

  • How to select the best tools for sample introduction based on your compound
  • How new tools can reduce or eliminate sample preparation for results in <30 seconds
  • New workflows to maximize your time in the lab by simplifying complex processes

This webinar was presented at the 2023 LabXpo Virtual event by Lab Manager  and LabX, recorded July 20, 2023.

Polymer Defect Engineering – Conductive 2D Organic Platelets from Precise Thiophene-Doped Polyethylene

Authors: Max Planck Institute for Polymer Research, Germany; University of Twente, Netherlands


We developed a simple way to create 2D conductive nanostructures with dielectric cores and conductive surfaces based on polyethylene with in-chain thiophene groups. Generally, thiophene-based polymers show great conductive properties, but exhibit a poor processability. Here, we use the crystallization of a polyethylene chain with precisely distributed thiophene groups as the platform for a self-organization of a lamellar structure. During crystallization, thiophene groups are expelled to the crystal surface. Subsequent copolymerization with 3,4-ethylenedioxythiophene (EDOT) molecules finally yields 2D platelets with a conductive surface. The electric properties of the surface are demonstrated by conductivity measurements. Given the molecular structure of the polymer, it can be assumed that the conductive layer consists of only one monoatomic layer of polymerized thiophene. We thus show a new way to create an ultra-thin, conductive surface on a polymer surface in just a few steps. Hence, the method presented here opens up a wide range of possibilities to produce complex, nanoscale electronic structures for microelectronic applications.

Mass spectrum analysis was obtained by ASAP/CMS using the Advion Interchim Scientific® ASAP® Atmospheric Solids Analysis Probe and expression® Compact Mass Spectrometer (CMS)

Application of open port sampling interface mass spectrometry (OPSI‐MS) to deuterium exchange as an aid for structural elucidation

AstraZeneca, United Kingdom


Deuterium exchange has been demonstrated to provide additional information to accurate mass measurement and collision‐induced dissociation on unknown chemical structures. An enhanced method for rapid deuterium exchange could make this technique more routine for structural elucidation. Open port sampling interface mass spectrometry (OPSI‐MS) with an aprotic solvent offers a rapid method for performing deuterium incorporation.

Schematic of OPSI

This publication features the Advion Interchim Scientific® Touch Express OPSI with the expression® Compact Mass Spectrometer (CMS).

The mucin-degradation strategy of Ruminococcus gnavus: The importance of intramolecular trans-sialidases

Institute of Food Research, Genome Analysis Center, Aix-Marseille University, University of East Anglia


We previously identified and characterized an intramolecular trans-sialidase (IT-sialidase) in the gut symbiont Ruminococcus gnavus ATCC 29149, which is associated to the ability of the strain to grow on mucins. In this work we have obtained and analyzed the draft genome sequence of another R. gnavusmucin-degrader, ATCC 35913, isolated from a healthy individual. Transcriptomics analyses of both ATCC 29149 and ATCC 35913 strains confirmed that the strategy utilized by R. gnavus for mucin-degradation is focused on the utilization of terminal mucin glycans. R. gnavus ATCC 35913 also encodes a predicted IT-sialidase and harbors a Nan cluster dedicated to sialic acid utilization. We showed that the Nan cluster was upregulated when the strains were grown in presence of mucin. In addition we demonstrated that both R. gnavus strains were able to grow on 2,7-anyhydro-Neu5Ac, the IT-sialidase transglycosylation product, as a sole carbon source. Taken together these data further support the hypothesis that IT-sialidase expressing gut microbes, provide commensal bacteria such as R. gnavus with a nutritional competitive advantage, by accessing and transforming a source of nutrient to their own benefit.

Mass spectrometry analysis was performed on the Advion Interchim Scientific® expression® Compact Mass Spectrometer (CMS) and the data was evaluated using Advion Interchim Scientific® Data Express software.