Mass spectrometry guided purification for efficient isolation of natural products at semi- and preparative scale

In natural product research the isolation of compounds from crude extracts is a key element. An increase in the efficiency of the purification process, by improvement of instrumental and methodological approaches, remains a crucial point. In this respect, modern flash chromatography, has evolved and uses 15 μm spherical particles for efficient separation at moderate pressures. Flash C-18 was tested for the rapid isolation of various plant secondary metabolites of interest.

Positive Ion APCI LC/MS Analysis of Enlite Herbicides

There must be better ways to do sample preparation for food matrices! And with good sample prep better analyses occur. It is human nature to resist change. Let us embrace new ways of doing things if they can be shown to be better, faster and easier.

Real-Time monitoring of a Suzuki reaction utilizing a hood-based compact mass spectrometer

A novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions.

Medical chemists are routinely faced with personally over a hundred new chemical entities (NCE’s) each year for testing as future pharmaceutical drug candidates. The goal is to prepare a high yield, relatively pure product via an optimized synthetic route.