The expression® CMS (Compact Mass Spectrometer) is the ideal instrument for the teaching lab thanks to its small size, ease of use, and one-click software. This pocket guide of classroom experiments offers students the ability to gain hands-on instrument experience by eliminating complex and difficult sample preparation.
This webinar features several useful tools to simplify or even eliminate the sample preparation involved prior to mass spectrometry. In this educational session you will learn about several prep-free mass spec techniques that are available, and how to select which method is best for your analysis. Advion will share their perspectives on some of the new tools and protocols to minimize and simplify sample preparation. You’ll learn how to reduce your time in the lab and see your mass spec results in as little as 30 seconds!
As an attendee, you will learn more about:
This webinar was presented at the 2023 LabXpo Virtual event by Lab Manager and LabX, recorded July 20, 2023.
Metal-based compounds have found utility in various fields such as clinical, energy, food safety and environmental to name a few. Creating the metal complex is the last step in a synthetic process, but it is critical to have the proper conditions for monitoring air-sensitive compounds to get the desire product and that side products are kept to a minimum to maximize yield.
In this application note, the inert atmospheric solid analysis probe (iASAP) and expression Compact Mass Spectrometer (CMS) was used to quickly sample and measure a modification of a published synthesis by Pfeiffer.
The research in this application note was presented at the 66th Annual Conference of the American Society of Mass Spectrometry (ASMS 2018)
The Atmospheric Solids Analysis Probe (ASAP™) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation. The inert ASAP (iASAP) is a modification of this technique, allowing easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glove box or Schlenk line to prevent oxidation.
The technique allows a synthetic chemist to perform real-time reaction monitoring by sampling the compound with the special iASAP probe, which is designed to provide access to the sample without disturbing the inert environment, then transferring the sample to the CMS, while continuing to protect it in an inert environment where it is ionized by atmospheric pressure chemical ionization (APCI). Mass Spectra are acquired in seconds.
For Direct Mass Analysis of Air-Sensitive Samples, Catalysts and Organometallics at the Bench With the expression® CMS
The Atmospheric Solids Analysis Probe (ASAP®) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation at the bench, right next to the reaction. The inert ASAP (iASAP) is a modification of this technique, allowing easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glove box or Schlenk line to prevent oxidation.
The technique allows a synthetic chemist to perform real-time reaction monitoring by sampling the compound with the special iASAP probe, which is designed to provide access to a sample protected in a glovebox or Schlenk line, then transferring the sample to the CMS, while continuing to protect it in an inert environment where it is ionized by atmospheric pressure chemical ionization (APCI). Mass Spectra are acquired in seconds.
Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP ®) without exposure to the air presents a problem. Here, the inert ASAP probe (iASAP), a modification of the technique developed by Professor Ingo Krossing’s group at the Albert-Ludwigs-University of Freiburg, allows sampling and transportation in an environment of inert gas to prevent decomposition of the compound.
Introducing a new type of mass spectrum, available exclusively in the Advion Peak Express™ software suite: the Delta Spectrum (ΔS). The ΔS is available with the expression® compact mass spectrometer (CMS) to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z in advance.
With the Peak Express™ software featuring ΔS, you can:
The inert Atmospheric Solids Analysis Probe (iASAP) allows easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glovebox or Schlenk line.
Quant Express, an addition to Advion’s user-friendly Mass Express 4.0 software suite, features quantitation to create a fully integrated software system for expression CMS users.