Higher purity. Higher Yield. Optimize your purification workflow, from lab scale to scale-up.

This Webinar was originally presented November 9, 2023 on LabRoots.com

In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover:

  • How to select the ideal purification solution for your lab’s specific needs
  • How to optimize your purification workflow daily, to automate compound ID and fraction confirmation – using simple, prep free tools
  • How your cell phone can be used for automated method development
  • How column selection factors in to your workflow, and why exploring what is best for your method matters

Chase Needham, puriFlash and PrepLC Applications Scientist, Advion Interchim Scientific®

Direct, multielement determinations from cotton swipes via Plate Express microextraction coupled to an inductively coupled plasma mass spectrometer, SOLATION® ICP-MS

Cameron J. Stouffer and R. Kenneth Marcus *


Cloth swipes are a fairly common sampling modality, having relevance across a wide variety of applications including environmental analysis, forensics, and bioassays. One of the biggest attractions of swipes (and related paper substrates) is the ease of sample collection and transportation, where just the swipe of a surface is required to collect particulates or solution phase species, with the substrate then readily transported to laboratory facilities. Additionally, the possibility to sample low-volume analytes, such as blood, gunshot residue, etc., provides additional benefits. The modes for the analytical sampling of the immobilized material vary greatly based on the means of analysis. These vary from direct solid analysis by a variety of optical probing methods, to solvent rinsing/extraction, and complete ashing/digestion of the cloth to liberate adsorbed species. Of the methods applied for elemental (metals) analysis of swipe materials, inductively coupled plasma-mass spectrometry (ICP-MS) is the most versatile in terms of coverage and sensitivity. Recently, a direct microextraction approach has been described for uranium isotope ratio determinations. Here, we describe the initial methodology development towards the use of the Advion Interchim Scientific® Plate Express microextraction device, coupled to an Advion Interchim Scientific® SOLATION® ICP-MS, for simultaneous, multielement analysis. Practical means of identifying test sites and evaluating elution quality are described. Methods of multielement quantification are identified with preliminary figures of merit presented. Finally, use of the method to quantify metals spiked into a synthetic urine matrix is demonstrated. While areas of improvement are clearly suggested, this rapid (<2 min) method of direct microextraction into the ICP (Ex-ICP-MS) shows great promise for use across diverse applications.

Advion Interchim Scientific® SOLATION® ICP-MS and Plate Express (Advion, Ithaca, NY) was utilized.

A Handheld Guide: Fun & Easy Mass Spectrometry Experiments for your Teaching Lab

A book of experiments for your students

The expression® CMS (Compact Mass Spectrometer) is the ideal instrument for the teaching lab thanks to its small size, ease of use, and one-click software. This pocket guide of classroom experiments offers students the ability to gain hands-on instrument experience by eliminating complex and difficult sample preparation.

Rapid Analysis Using Direct Microextraction Assays Coupled to the New SOLATION® ICP-MS

Recorded February 2, 2023: LIVE Location, the 2023 European Winter Conference on Plasma Spectrochemistry


Janez Ilaš, Ph. D., Professor, University of Ljubljana
Fadi Abou-Shakra, Director of Advion Interchim Scientific® ICP-MS Portfolio

Join Advion Interchim Scientific® with guest speaker from the University of Ljubljana, Faculty of Pharmacy, to learn more about a new novel sample introduction method for ICP-MS utilizing direct analysis via microextraction. First you will learn microextraction methods with the Plate Express TLC Plate/microextraction reader coupled to the single-quadrupole expression® Compact Mass Spectrometer (CMS). After understanding the basics of the platform, you will learn more about how this technology was reimagined to suit the SOLATION® ICP-MS for a rapid method to determine isotopic analysis faster and easier than ever before.

Ready to learn more?

Mass Spectrometry for Teaching Chemistry Undergraduates – The expression® CMS & the SOLATION® ICP-MS

Recorded November 3, 2022: Featured talk in the LCGC Mass Spectrometry Symposium

Join Fadi Abou-Shakra, Director of ICP-MS Portfolio for Advion Interchim Scientific®, as he shares some of the organization’s latest mass spectrometry applications for the teaching lab. This includes student-friendly experiments using a compact single-quadrupole system, as well as simplified ICP-MS applications.

Fadi Abou-shakra started using ICP-MS in 1987 applying it for the analysis of trace elements in biological fluids and has been active in the field of atomic spectroscopy since then. He holds an MSc in Medical Physics and a PhD in Chemistry from the University of Surrey, England. He brings a wealth of experience in ICP-MS as a researcher, customer support specialist and a business manager.

Ready to learn more?

Development of New Synthetic Methodologies Enabled by Advion Interchim Scientific Workflow

Recorded May 5, 2022.

Join Daniel Kim, Ph.D., Assistant Professor ​Organic, Inorganic, Biological, from Temple University, as he presents several new methodologies developed for reaction discovery.

In this webinar, you will learn:

  • How to develop a fast and modular workflow for reaction discovery on a budget
  • The advantages to using Advion-Interchim Scientific suite of instruments
  • A review of unpublished work on developing new reaction discovery

Streamlined Benchtop Chemistry: Faster Workflow from Reaction to Fraction

Lab Manager Ask the Expert Webinar. Recorded September 7, 2022

Maximize your workflow—even with limited space at the bench. This webinar features innovative solutions for streamlining the chemists’ everyday needs, including reaction monitoring, purification, fraction collection, and evaporation. No matter what your application, the session will address some of the most common bottlenecks and how to avoid them to improve your process.

As a viewer, you will learn more about:

  • How to use TLC plates to make flash purification faster and more efficient
  • Software hacks leveraging sophisticated algorithms for better purifications
  • 30-second fraction ID to speed up the process
  • How evaporation can be easier, faster, and more reliable

Webinar speakers include:

Gary Williams
Vice President, Chemist & North American Sales
Advion Interchim Scientific

Nathaniel Kunzer
Product Specialist

Helium Shortages in the Chemistry Lab: Compound Characterization Using Helium-Free Techniques

Helium shortages are not new – annually, scientists see the cost of helium rise and fall like the stock market. Except this isn’t just a financial impact. Global helium shortages threaten to derail research and essential industry functions, taking down GC and high-field NMR instruments, bringing a once state-of-the-art lab down to a bare-bones facility.

This whitepaper explores the use of alternative reaction monitoring technology, including the expression® CMS (Compact Mass Spectrometer), Plate ExpressTM TLC Plate Reader, and ASAP® probe for liquid and solid samples – all helium-free alternatives for the chemistry laboratory.

Reaction Monitoring Capabilities at the Bench:

  • The expression® CMS offers an ideal reaction monitoring solution that will live on long beyond the helium shortage and become a centerpiece of the lab. The system offers a complete solution for: 
  • Batch and flow chemistry 
  • Fast compound identification and purity determination
  • …with little or no sample preparation required, and many novel sample introduction interfaces

University of Oxford, Chemistry Teaching Laboratories

Q: What is the focus of your lab’s research?

A: We run a large and very busy Teaching Laboratory, teaching practical skills to almost 600 undergraduates on the MChem degree course at Oxford University.

Q: What are your previous workflow and experiences challenges?

A: In many universities, undergraduate access to mass spectrometry is limited to the occasional use of a service machine, whose primary role is to support the research groups in the department. Undergraduates might be provided with data from such a service but rarely are able to collect this data themselves.

Q: Why did you incorporate the expression® CMS?

A: The expression® CMS is a fantastic instrument for undergraduate teaching. We have two machines – one set up for TLC/MS and the other with an ASAP® probe. Undergraduates, right from the first year, experience how easy it is to gather high quality, mass spectrometry data. With limited training, students are able to use the spectrometers themselves, with minimal risk of instrument damage. Collecting MS data is now as routine as getting an IR spectrum and the fast throughput of samples allows many students a day to collect data.

Q: Who would you recommend to purchase the expression® CMS?

A: We would recommend any undergraduate teaching lab to consider the purchase of the expression® CMS system. We have had our machines for 3-4 years now, and the reliability has been very good indeed. The quality of the data obtained sets our students up to use mass spectrometry in their future research careers.

Q: Do you have any publications or presentations using the expression® CMS?

A: Poster presentation: The Use of Mass Spectrometry in an Integrated Undergraduate Practical Course. Presented at the chemistry and physics education conference, ViCEPhEC, in 2019.

We are currently working on a paper with Professor Claire Vallance on the use of machine learning to classify food stuffs (fruit, tea, whisky, etc.) by mass spectrometry as an undergraduate project. We intend to publish this work in the Journal of Chemical Education in the coming months.