Mass Spec Simplified – Techniques for Reducing Sample Preparation Burden

This webinar features several useful tools to simplify or even eliminate the sample preparation involved prior to mass spectrometry. In this educational session you will learn about several prep-free mass spec techniques that are available, and how to select which method is best for your analysis. Advion will share their perspectives on some of the new tools and protocols to minimize and simplify sample preparation. You’ll learn how to reduce your time in the lab and see your mass spec results in as little as 30 seconds!

As an attendee, you will learn more about:

  • How to select the best tools for sample introduction based on your compound
  • How new tools can reduce or eliminate sample preparation for results in <30 seconds
  • New workflows to maximize your time in the lab by simplifying complex processes

This webinar was presented at the 2023 LabXpo Virtual event by Lab Manager  and LabX, recorded July 20, 2023.

What’s in My Sample? Mass Spectrometry Instruments

Mass spectrometry is an analytical technique used to determine the mass-to-charge ratio of ions in a sample and therefore the sample composition. This method is used across many industries including food and beverage, environmental monitoring, and clinical. There are many features of mass spectrometers that must be considered before purchasing such as the required mass analyzer technology, ionization source, and dissociation technique. Join Lab Manager and our panel of experts as we discuss how to decipher mass spectrometry technology offerings and find the right solution for your lab.

As an attendee, you will learn more about:

  • Available technology for performing mass spectrometry
  • Features to consider when purchasing mass spectrometry instruments
  • How to find the right mass spectrometer for your application

Food Science and Quality Control: Tools for Food & Beverage Testing

Lab Manager Tech Trends Webinar. Recorded June 25, 2020.

Food and beverage labs use techniques from other disciplines such as microbiology, environmental monitoring, and analytical chemistry to test for food and beverage contaminants. Unlike these disciplines, the food and beverage industry is highly regulated and therefore food and beverage labs have very specific needs. Join Lab Manager and our panel of experts as we discuss tools for food and beverage testing.

In this webinar, you will learn more about:

  • The latest technology for testing in the food and beverage lab
  • Applications for tools and technologies in the food and beverage lab
  • Considerations when purchasing instruments for food and beverage testing

Analysis of Volatile Compounds in the Fermentation of Homebrewed Beer

In this application note, the Advion Interchim Scientific expression® Compact Mass Spectrometer (CMS) with volatile APCI (vAPCI) is used to analyze volatile compounds present during the fermentation of homebrewed beer by Stephanie Rankin Turner of Loughborough University.

The complex flavor of beer is primarily a result of the ingredients used, the brewing method, and conditions during fermentation. The analysis of beer throughout this process can be invaluable. Being one of the most widely consumed beverages worldwide, rapid and reliable analytical techniques are essential to keep up with demand and production.

This note demonstrates the use of the Advion Interchim Scientific expression® CMS with vAPCI for the analysis of volatile compounds from the headspace of homebrew beer and hops. The Venturi-assisted interface of the instrument enabled rapid sampling of volatiles, allowing the changing volatile profile of the homebrew to be observed throughout the fermentation process. This simple method would be suitable for fast quality control during alcoholic beverage production.

Tools for the Food & Beverage Lab Webinar

In this Lab Manager webinar, Dr. Daniel Eikel, Advion Director of Product Applications and Customer Service reviews the use of the Advion expression Compact Mass Spectrometer (CMS) for food and beverage analysis.

As an attendee, you will learn more about:

  • How leading technologies and techniques affect food science researchers
  • How to establish workflows that optimize the efficiency of your food science lab
  • New and novel applications in the field of food and beverage science

Breath Selection Methods for Compact Mass Spectrometry Breath Analysis

Loughborough University, Translational Chemical Biology Research Group


Compact mass spectrometry (CMS) is a versatile and transportable analytical instrument that has the potential to be used in clinical settings to quickly and non-invasively detect a wide range of relevant conditions from breath samples. The purpose of this study is to optimise data preprocessing protocols by three proposed methods of breath sampling, using the CMS. It also lays out a general framework for which data processing methods can be evaluated. Methods.This paper considers data from three previous studies, each using a different breath sampling method. These include a peppermint washout study using continuous breath sampling with a purified air source, an exercise study using continuous breath sampling with an ambient air source, and a single breath sampling study with an ambient air source. For each dataset, different breath selection (data preprocessing) methods were compared and benchmarked according to predictive performance on a validation set and quantitative reliability of m/z bin intensity measurements. Results. For both continuous methods, the best breath selection method improved the predictive model compared to no preselection, as measured by the 95% CI range for Youden’s index, from 0.68–0.86 to 0.86–0.97 for the exercise study and 0.69–0.82 to 1.00–1.00 for the peppermint study. The reliability of intensity measurements for both datasets (as measured by median relative standard deviation (RSD)), was improved slightly by the best selection method compared to no preselection, from 18% to 14% for the exercise study and 7%–5% for the peppermint study. For the single breath samples, all the models resulted in perfect prediction, with a 95% CI range for Youden’s index of 1.00–1.00. The reliability of the proposed method was 38%. Conclusion. The method of selecting exhaled breath from CMS data can affect the reliability of the measurement and the ability to distinguish between breath samples taken under different conditions. The application of appropriate data processing methods can improve the quality of the data and results obtained from CMS. The methods presented will enable untargeted analysis of breath VOCs using CMS to be performed.
Compact Mass Spectrometer (CMS).

Gas Phase Sample Analysis By Volatile APCI (vAPCI)

Volatile Atmospheric Pressure Chemical Ionization (vAPCI) combined with Advion Interchim Scientific’s expression® compact mass spectrometer (CMS) is a fast and easy method to analyze the headspace of a sample with no additional sample prep.

The vAPCI ion source is a simple, powerful tool for gas phase sample analysis. The technique can quickly and confidently identify compounds in air, breath, headspace and other gas samples.

Transforming presumptive forensic testing: in situ identification and age estimation of human bodily fluids

Stephanie Rankin-Turner, Matthew A. Turner, Paul F. Kelly, Roberto S. P. King, James Reynolds

The ability to achieve rapid, in situ identification and age estimation of human bodily fluids can provide valuable information during the investigation of a crime. A novel direct analysis method now permits the rapid in situ identification and age estimation of human bodily fluids for forensic analysis at crime scenes. A thermal desorption surface sampling probe was developed and coupled with a compact mass spectrometer for the direct analysis of volatile organic compound (VOC) profiles of human bodily fluids within two months and in different environmental conditions, without the need for prior sample preparation. The method is not only capable of identifying bodily fluids and discriminating against common interferent species, but also differentiating between bodily fluid stains of different ages over a time period of two months. This demonstrates the potential for rapid in situ identification and age estimation of bodily fluids without the need for contaminative presumptive tests or time-consuming sample preparation.

The MS analysis was carried out using Advion Interchim Scientific Expression® CMS vAPCI.

Teaching Mass Spectrometry For Chemists

Bring mass spectrometry into your classroom for remote or on-site learning with a training course for the expression® Compact Mass Spectrometer (CMS).

Advion offers an affordable MS teaching package that includes:

  • A compact, easy-to-use benchtop mass spectrometer for both students and researchers
  • Recorded lectures and video lab content
  • Lecture slides to share or adapt to your own teaching style

Computer Software
PLUS: Easy, student-friendly software. Select the workflow, the type of compounds, and students are on their way with just a few clicks of the mouse.

A research-grade mass spec, the expression® CMS is ideal for teaching because of its small size, ease of use, and one-click software. When class is not in session, the system is ready for research, making this a versatile choice for university labs seeking state of the art equipment paired with streamlined teaching modules.