The results from this study shed some light on the relative merits of APCI vs ESI as well as the importance of the optimal ionization polarity for the LC/MS determination of the selected acidic and basic small molecule drugs.
Ultra (high) performance liquid chromatography (UPLC/UHPLC) is a relatively new technique, and is valued for its speed, efficiency and the quality of information provided. Many synthetic and medicinal chemistry laboratories are moving to tehis process to improve their workflows and save time.
See two simple workflows for using Compact Mass Spectrometry for product control and law enforcement of cannabis related plant products.
LabTube interviews David Patteson of Advion.
In this new profile, David Rotella of Montclair State University discusses how the expression CMS allowed him to bring industry-level technology to his small academic research group.
Despite the potential to achieve novel and interesting chemical transformations, photochemistry still remains largely underutilized by the organic chemistry community. This presentation highlights ways of overcoming common difficulties.
In this new profile, John Matson of Virginia Tech discusses how the expression CMS has sped up small molecules and peptide synthesis as well as enabled qualitative decomposition studies on compounds.
Neil Vasdev, et al.
Chem. Commun., 2013,49, 8755-8757
Lead by Neil Vasdev, a collaborative group from Harvard Medical School, Massachusetts General Hospital, Northeastern University, and Advion, have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[18F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[18F]fluoroaniline were achieved within 3 minutes.
Advion now presents the new expression S compact mass spectrometer (CMS) designed specifically for academic, industry and research chemistry groups.
“Advion has brought to the chemist’s bench the best-in-class mass spectrometer performance previously reserved only for mass spec specialists.”
Now you have a choice for the best fit for your specific application.
The expression S is available now for orders with a 12 week lead time.
Analyzes 80% of compounds that GC/MS can’t
LC/MS is the gold standard in separation science, but until now, was financially out of reach for many teaching instutions. The expression CMS is an electrospray mass spectrometer that couples to most LC systems and is easy to maintain and use for even the most novice user.
Contact Advion today to learn more about creative financing options available to small academic institutions. Ask about our leasing program.