The expression CMS is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.
Direct Mass Analysis from Solid & Liquid Samples
The expression CMS improves the chemist’s workflow by using a direct analysis probe, otherwise known as ASAP® (Atomospheric Solids Analysis Probe), to permit chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.
“The CMS is a very helpful instrument that has shorten product detection times.”
Professor Meng of the Beijing Institute of Technology uses mass spectrometry as a tool for synthetic intermediates. With a large number of products to run, Meng and his team needed to shorten product detection times.
Determination of Emerging Nitrogenous Economic Adulterants in Milk Proteins by HPLC/Compact Mass Spectrometry
The ability to rapidly screen milk ingredients in the manufacturing plants for potential economic adulterants is becoming increasingly important.
A simpler and more cost-effective alternative for frontline screening has been developed.
Utilizing a novel compact mass spectrometer (CMS) for the detection and quantification of chemical compounds related to cannabis
Regardless of the legal status of cannabis and its chemical compounds, both the quality control in legal markets as well as the law enforcement of it’s illegal status require simple, unequivocal and legally defendable analysis methods for the detection and quantification of its major chemical compounds.
Whenever a detector of high selectivity and sensitivity is required, a mass spectrometry based analysis workflow is usually the method of choice and we here demonstrate the analysis of delta9-Tetrahydrocannabinol (THC), Canabidiol (CBD) and Canabinol (CBN) utilizing a novel compact mass spectrometer (expression-S, Advion, NY) coupled to ultra-high performance liquid chromatography (UHPLC) or thin layer chromatography (TLC).
On-Demand Webinar: HRMS, Chemical Modification and Liquid Extraction Surface Analysis for Lipidome Profiling of Colon Adenocarcinom
In this presentation, the development and application of a straightforward and high throughout analysis strategy consisting of high-resolution ‘shotgun’ mass spectrometry (MS), ‘targeted’ tandem mass spectrometry (MS/MS), functional group specific chemical modification and in situ liquid extraction of cell culture samples is described for the comprehensive identification, characterization and quantification of multiple lipid classes from within a colon adenocarcinoma cell line, SW480, and its metastasized derivative, SW620.
Evaluation of a compact mass spectrometer for routine support of pharmaceutical chemistry
Bu X1, Yang J2, Gong X2, Welch CJ3
1Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
2Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
3Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
The suitability of a recently introduced inexpensive, compact mass spectrometer detector is evaluated for supporting pharmaceutical chemistry investigations. While high performance/high cost MS detectors dominate the marketplace, there is growing recognition of the need for a small, inexpensive MS detector with reduced capabilities for supporting synthetic chemistry investigations, where reduced sensitivity and unit mass resolution are often suitable for solving routine problems. In this study, the fundamental performance characteristics of the recently introduced Advion compact mass spectrometer were evaluated, investigating the use of the instrument for routine product and impurity identification, reaction monitoring, evaluation of potential genotoxic impurities and study of high molecular weight biomolecules. In general, the results of the evaluation show this compact and inexpensive mass spectrometer to be well suited for providing reliable support for pharmaceutical chemistry investigations, with sub-nanogram limit of detection and impurity identification below 0.1% being possible in some instance.
Latest Peer-Reviewed Publication
Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
Lucie Guetzoyan,a Richard J. Ingham,a Nikzad Nikbin,a Julien Rossignol,a Michael Wolling,a Mark Baumert,b Nicola A. Burgess-Brown,c Claire M. Strain- Damerell,c Leela Shrestha,c Paul E. Brennan,c Oleg Fedorov,c Stefan Knappc and Steven V. Ley*a
aInnovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK.
bAdvion Ltd, Harlow Enterprise Hub, Edinburgh Way, Harlow, Essex, CM20 2NQ, UK cStructural Genomics Consortium and Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK
A combination of conventional organic synthesis, remotely monitored flow synthesis and bioassay platforms, were used for the evaluation of novel inhibitors targeting bromodomains outside the wellstudied bromodomain and extra terminal (BET) family, here exemplified by activity measurements on the bromodomain of BRD9 protein, a component of some tissue-specific SWi/SNF chromatin remodelling complexes. The Frontal Affinity Chromatography combined with Mass Spectrometry (FAC-MS) method proved to be reliable and results correlated well with an independent thermal shift assay.
“I recommend the expression CMS to all laboratories that routinely synthesize new small molecules”
Prof. Dr. Nathan Luedtke and his group at the University of Zurich utilize the CMS to address unresolved questions in DNA chemical biology by developing molecular probes for characterizing structure, function and dynamics of nucleic acids in vivo.
Electrospray LC/MS response differences from equimolar quantities of drugs using a CMS equipped with atmospheric pressure ionization
The results from this study shed some light on the relative merits of APCI vs ESI as well as the importance of the optimal ionization polarity for the LC/MS determination of the selected acidic and basic small molecule drugs.