Comprehensive Reaction Monitoring & Flow Chemistry Resources

Did I make my compound?”

 

It’s a common phrase that may follow you around the lab daily. With time-sensitive reactions coupled with the time-sensitive need to confirm data, fast reaction monitoring is essential for bench chemists looking for the most streamlined daily workflow.

The expression Compact Mass Spectrometer (CMS) addresses the need of organic and synthetic chemists to understand the optimal time to quench a reaction mixture. They can obtain answers within minutes rather than hours or days. Additionally, multiple inlet techniques like the atmospheric samples analysis probe (ASAP), Plate Express TLC plate reader, direct injection and more provides the ultimate in flexibility for sample analysis without the need for complex sample preparation. In addition, the use of the expression CMS in flow chemistry applications is an ideal reaction monitoring tool.

Learn more about the essential tools for fast reaction monitoring in this comprehensive resource guide:

 

Whitepaper: Compact Mass Spectrometry – A Complete Reaction Monitoring Solution

• Learn different sample techniques and ionization methods  based on your compounds

• See how prep-free, 30 second analysis can benefit your lab

• Find out how an optimized flow chemistry tool for fast reaction monitoring can take some burden off high resolution instruments with long run times

 

 

Webinar: Self-Optimizing Flow Reactors, Chris Horbaczewskyj, University of Leeds

• Learn advantages and disadvantages of both batch and flow chemistry

• Find out how on-line analytics within continuous flow chemistry allow reactions to be monitored in real-time allowing immediate characterization and the ability to optimize

 

 

Application Note: Real-Time Reaction Monitoring of a Solution-Phase Peptide Synthesis using the Plate Express and expression TLC/CMS

• Read how a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way for chemists to overcome synthetic challenges and optimize chemical reactions

• Learn how peptides of pharmaceutical interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy

 

 

 

Application Note: Analysis of Two Reaction Products by Direct Analysis Probe on a Compact Mass Spectrometer

• Find out how, with one swipe, a liquid or solid can be introduced in to the mass spec for reaction monitoring results in seconds

• Read how the ASAP with the CMS is used in identification of the products of a reaction where two products are possible

 

 

 

Application Note: Suzuki Reaction Monitoring Using Compact Mass Spectrometry with TLC Interface

• Learn how anonline thin-layer chromatography TLC/CMS technique using the Advion expression compact mass spectrometer (CMS) and Plate Express™ interface tcan provide compound structural information without sample preparation after TLC separation

 

 

 

Publication: A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis (Open Access)

• Learn how the expression CMS was integrated in to a new workflow developed by the University of Cambridge Ley Lab that offers a modular software system that enables researchers to monitor and control chemical reactions via the Internet, using any device from any location in the world

 

 

 

Publication: Controlling an organic synthesis robot with machine learning to search for new reactivity (Open Access)

• Using the Advion expression Compact Mass Spectrometer and developments in robotics and AI, learn how chemical reactions can be performed faster than they can be performed manually. Not only is speed a benefit, the development also can predict the reactivity of possible reagent combinations after conducting only a small number of experiments

 

 


 

BONUS SOFTWARE WEBINAR: New Developments in Mass Spectrometry – Peak Express

• Find out if you made your compound with a new type of mass spectrum: the Delta Spectrum (ΔS). The patented ΔS is able to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z

• How to easily find adducts, dimers, fragments, side-reactions and other unexpected compounds at the click of a button, in real-time or with post-processing

• How to use Peak Express software to highlight minor components in complex mixtures and dirty matrices, and can give you the ability to control mass-directed purification without providing the compound mass

• How to easily acquire XIC-quality data while scanning the entire mass range, allowing Peak Express™ to tell you the m/z

 

AI robot mixes chemicals to discover reactions – publication and video

Publication Alert: Controlling an organic synthesis robot with machine learning to search for new reactivity
Jarosław M. Granda, Liva Donina, Vincenza Dragone, De-Liang Long, and Leroy Cronin / Nature, Published online 2018 Jul 18

Using the Advion expression Compact Mass Spectrometer and developments in robotics and AI, learn how chemical reactions can be performed faster than they can be performed manually. Not only is speed a benefit, the development also can predict the reactivity of possible reagent combinations after conducting only a small number of experiments.


Video Alert: Not only was this development published in Nature, but a video featuring the system at work is also available:

Reporter Adam Levy talks to chemist Lee Cronin about his team’s search1 for new chemical reactions.

“It’s very difficult when you ask a chemist in the lab to go discover something. It’s a bit like asking someone to go in a boat now and find a new continent,” Cronin said.

Join our Webinar: Self-optimising Continuous Flow Reactors

Join us for a webinar with Chris Horbaczewskyj from the University of Leeds and Jack Henion, Advion’s Chief Scientific Founder on Thursday, April 26, 2018. Chris is working on the self-optimisation of continuous flow reactions using online mass spectrometry. Continuous flow and process optimisation are relatively new methods involved in chemical synthesis. This webinar outlines the workflow of the Bourne group at the University of Leeds for process development applications.

Register for this webinar to learn more!

Self-Optimising Continuous Flow Reactors Webinar

Join us for a Webinar with Chris Horbaczewskyj of the University of Leeds and Jack Henion, Advion’s Chief Scientific Founder, on Thursday, April 26, 2018 at 10am EST / 3PM GMT.

This presentation outlines the work carried out within the Bourne group at the University of Leeds for process development applications:

  1. Use of flow chemistry with online HPLC in the self-optimisation of reactions
  2. Use of online mass spectrometry for the optimisation of continuous flow reactions using an experimental design approach
  3. The development of new algorithms for multiple variable optimisation in chemical systems

Join Advion at Supply Side West in Las Vegas!

Join us on the expo floor September 27-28 in Las Vegas, NV! If you’re attending the expo, analytical testing for ingredients is essential for every supplier and buyer. Stop by to learn how Advion’s instruments can streamline your internal labs and help you ensure you have pure, quality, pesticide-free product.

Please stop by booth #XX117 to learn more about Advion’s full array of mass spec testing tools, featuring easy-to-use, novel sample techniques for maximum efficiency in the lab.

Join Advion at SupplySide West in Las Vegas! Booth #XX117


Join us on the expo floor September 27-28 in Las Vegas, NV! Analytical testing for ingredients is essential for every supplier and buyer. Stop by to learn how Advion’s instruments can streamline your laboratory workflow and help you ensure you have safe, high-quality products.

Visit booth #XX117 to learn more about our full array of mass spec tools for testing, featuring easy-to-use, novel sample analysis techniques for maximum efficiency in the lab.

Several successful applications of the Advion expression Compact Mass Spectrometer (CMS) system for food and ingredients testing include:

  • The Analysis of Different Grades of Olive Oil by Volatile Mass Spectrometry: In this application note, we demonstrate the use of the Advion expression CMS with a volatile APCI (vAPCI) ion source technique that allows testing of olive oil samples to determine if they are truly extra-virgin, virgin, or lampante grade.
  • Classifying cheeses by volatile APCI Compact Mass Spectrometry: In this application note we demonstrate the capability of the Advion expressions CMS to analyze volatile fatty acids of various types of cheeses using our volatile vAPCI ion source.
  • A Sudan Dyes Analysis Using Compact Mass Spectrometry with a TLC Interface: In this note, a TLC/CMS method using the expression CMS coupled with the Plate Express interface is introduced for the detection of 7 Sudan dyes in a chili matrix. 
  • Chemically Tracking Spoilage of Meat Using Volatile Compact Mass Spectrometry: This application note demonstrates the use of the Advion expression CMS coupled with a vAPCI ion source to directly detect several key chemicals given off by meat as it spoils at ambient temperature. Evolution of putrescine, cadaverine, and indole were measured over several days as meat spoiled.
  • Looking for more SupplySide West details? Visit the official site for lectures, exhibitors, social events and more!

Background: SupplySide West brings together more than 15,000 ingredient buyers and suppliers from the dietary supplement, beverage, functional food, personal care and sports nutrition industries. SupplySide West is all about the science and strategy around the development of finished products that drive the global business economy. Join us this year to learn about new trends from over 1,200 exhibitors and 140 hours of educational and conference programming. The 2017 SupplySide West event takes place in Las Vegas, NV, September 25-29. The expo floor where Advion will be located is open September 27-28. We hope to see you at SupplySide West 2017!

Join Advion at ACS Fall 2017 in Washington DC

Join us on the expo floor August 20-22 in Washington, DC for the annual Fall American Chemical Society conference. Here you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #1401 to learn more about Advion’s full array of MS tools for chemists.

This year, we are hosting a workshop titled, “Mass Spectrometry for Chemists – Direct Analysis of TLC Plates, Solids, Liquids and Gases.” 

Date/Time/Location: Tuesday, August 22, 9:30a-12p — Room 4 on the Conference Floor, complimentary breakfast will be served

Join Advion’s Workshop at ACS Fall 2017 in Washington D.C. & at Booth #1401

Join us on the expo floor August 20-22 in Washington, DC for the annual Fall American Chemical Society conference. Here you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #1401 to learn more about Advion’s full array of MS tools for chemists.

This year, we are hosting a workshop titled, “Mass Spectrometry for Chemists – Direct Analysis of TLC Plates, Solids, Liquids and Gases.” 
Date/Time/Location: Tuesday, August 22, 9:30a-12p — Room 4 on the Conference Floor, complimentary breakfast will be served
Description:With the daily need to analyze a variety of solids, liquids and gases sample techniques are indispensable in a busy lab. Learn how a single instrument can be adapted to each of these sample requirements and rapidly changed to accommodate back-to-back assays. Listen to users in the field speak about innovative sample inlets, including:

  • TLC/CMS
  • ASAP® (Atmospheric Solids Analysis Probe) – now compatible with air sensitive compounds with the addition of the iASAP probe
  • Direct flow injection
  • vAPCI for analysis of headspaces

Learn how they reduced sample preparation and streamlined their everyday workflow. Also learn about two new exciting product launches from Advion.

Featured Speakers:

  • David Patteson, Advion President & CEO
  • Jack Henion, Ph. D., Advion Co-Founder and Chief Scientific Officer, Emeritus Professor, Cornell University
  • John Matson, Ph. D., Matson Research Group on Macromolecular and Supramolecular Chemistry, Assistant Professor, Virginia Tech – Peptide-Based Materials for Controlled Delivery of Hydrogen Sulfide
  • Keri Colabroy, Ph. D., Associate Professor of Chemistry, Muhlenberg College & Brock Juliano, Student – CMS assisted identification of Small-Molecule, Bacterial Metabolites Using ESI with Direct Injection
  • Neil Vasdev, Ph. D., Vasdev Lab at Massachusetts General Hospital, Director of Radiochemistry, Associate Professor of Radiology, Harvard – Applications of the CMS in a Radiochemistry Lab

Advion will also launch two new technologies in to the expression CMS family:

Looking for more ACS details? Visit the official site for lectures, exhibitors, posters, social events and more!

Background: The American Chemical Society National Meeting takes place in the spring and fall each year, offering the latest in chemistry developments, achievements and awards. The 2017 ACS fall meeting is in Washington, D.C., August 20-24. The expo floor where Advion will be located is open August 20-22. We hope to see you at ACS Fall 2017!

ASMS 2017 Advion Highlights

ASMS 2017 brought nearly 7,000 attendees under one roof, ready to learn the newest products and latest applications in the world of mass spec. The Advion CMS and TriVersa NanoMate were both a topic for discussion, featured during Advion poster sessions, and also included in posters from customers who have found the instruments an essential part of their mass spec workflow.

ASMS 2017 Advion Highlights

ASMS 2017 brought nearly 7,000 attendees under one roof, ready to learn the newest products and latest applications in the world of mass spec. The Advion CMS and TriVersa NanoMate were both a topic for discussion, featured during Advion poster sessions, and also included in posters from customers who have found the instruments an essential part of their mass spec workflow.

Click on any of the posters or presentations to view full size.

The TriVersa NanoMate was featured in the following posters and presentations:

POSTER: Histology Directed Liquid Surface Extractions Coupled Directly to Liquid Chromatography for Improving Identification Strategies in Advanced IMS Applications – Vanderbilt University



POSTER: Lipid parameters associated with obesity identified using a high-throughput Shotgun Lipidomics technology – Thermo Fisher Scientific and Lipotype


POSTER: Native LESA mass spectrometry: Direct analysis of proteins and their complexes – University of Birmingham, University of Oxford


 


POSTER: A Rapid Mixing Device to Detect Early Intermediates in Hepatitis B Virus Assembly by Charge Detection Mass Spectrometry – Indiana University


POSTER: Isomeric Complexity of Glycosylation in MCF-7 and MDA-MB-231 Cell Lines Revealedby Detailed Analysis with Ion Trap Mass Spectrometry – Glycan Connections, LLC / University of New Hampshire, Durham


POSTER: Simultaneous Label-free Quantitation of Proteoforms, Proteoform Ratios, and Total Protein up to 80kDa Split across Physiochemical Multidimensional Space – Southwestern Medical Center / University of Texas at Dallas


PRESENTATION: Implementation of a spatial metabolomics approach for exploring interactions within a tripartite plantfungus-cyanobacterium system – EMSL


PRESENTATION: Liquid extraction surface analysis mass spectrometry for protein analysis directly from clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa – University of Birmingham / National Physical Laboratory, Teddington


The expression CMS was featured in the following Advion posters:

POSTER: Delta Ion Current (IC)- A novel approach to plottotal ion currents enhancing the signal from newly detected ions – Authors: Lawrence Klecha, Daniel Mikel, Advion Inc.


POSTER: Identification of an unknown biocide by volatile atmospheric pressure chemical ionization (vAPCI) and compact mass spectrometry (CMS) – Authors: Daniel Eikel, Simon J. Prosser, Advion Inc.


POSTER: Compact mass spectrometer (CMS) analysis of uniformly 13C-labeled amino acids to identify authentic therapeutic drugs and protect against counterfeits – Authors: Daniel Mikel, Simon J Prosser, Advion, Inc. / Chris Beecher,  IROA Technologies