ASMS 2017 Advion Highlights

ASMS 2017 brought nearly 7,000 attendees under one roof, ready to learn the newest products and latest applications in the world of mass spec. The Advion CMS and TriVersa NanoMate were both a topic for discussion, featured during Advion poster sessions, and also included in posters from customers who have found the instruments an essential part of their mass spec workflow.

Click on any of the posters or presentations to view full size.

The TriVersa NanoMate was featured in the following posters and presentations:

POSTER: Histology Directed Liquid Surface Extractions Coupled Directly to Liquid Chromatography for Improving Identification Strategies in Advanced IMS Applications – Vanderbilt University

POSTER: Lipid parameters associated with obesity identified using a high-throughput Shotgun Lipidomics technology – Thermo Fisher Scientific and Lipotype

POSTER: Native LESA mass spectrometry: Direct analysis of proteins and their complexes – University of Birmingham, University of Oxford


POSTER: A Rapid Mixing Device to Detect Early Intermediates in Hepatitis B Virus Assembly by Charge Detection Mass Spectrometry – Indiana University

POSTER: Isomeric Complexity of Glycosylation in MCF-7 and MDA-MB-231 Cell Lines Revealedby Detailed Analysis with Ion Trap Mass Spectrometry – Glycan Connections, LLC / University of New Hampshire, Durham

POSTER: Simultaneous Label-free Quantitation of Proteoforms, Proteoform Ratios, and Total Protein up to 80kDa Split across Physiochemical Multidimensional Space – Southwestern Medical Center / University of Texas at Dallas

PRESENTATION: Implementation of a spatial metabolomics approach for exploring interactions within a tripartite plantfungus-cyanobacterium system – EMSL

PRESENTATION: Liquid extraction surface analysis mass spectrometry for protein analysis directly from clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa – University of Birmingham / National Physical Laboratory, Teddington

The expression CMS was featured in the following Advion posters:

POSTER: Delta Ion Current (IC)- A novel approach to plottotal ion currents enhancing the signal from newly detected ions – Authors: Lawrence Klecha, Daniel Mikel, Advion Inc.

POSTER: Identification of an unknown biocide by volatile atmospheric pressure chemical ionization (vAPCI) and compact mass spectrometry (CMS) – Authors: Daniel Eikel, Simon J. Prosser, Advion Inc.

POSTER: Compact mass spectrometer (CMS) analysis of uniformly 13C-labeled amino acids to identify authentic therapeutic drugs and protect against counterfeits – Authors: Daniel Mikel, Simon J Prosser, Advion, Inc. / Chris Beecher,  IROA Technologies

The 65th ASMS Conference on Mass Spectrometry and Allied Topics, June 4-8, Indianapolis

Join us in Indy for the annual ASMS Conference on Mass Spectrometry (MS) and Allied Topics. From posters to short courses, you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #506 during the show to learn more about Advion’s full array of MS tools for chemist, including:

  • The TriVersa Nanomate®(TVNM) LESA® with ESI chip® technology

  • The NEW inert atmospheric solids analysis probe (iASAP) for air sensitive compounds

Also, please attend one of our many presentations throughout the week:

  • Saturday June 3 – Sunday June 4, our scientific founder, Jack Henion, will be hosting a 2-day short course (advance registration required) titled “LC-MS: Advanced Techniques & Applications”
  • MP 342 – Monday, June 5, 10:30am – 2:30pm Dr. Daniel Eikel will be presenting a poster titled “Identification of an Unknown Biocide by Volatile Atmospheric Pressure Chemical Ionization (vAPCI) and Compact Mass Spectrometry (CMS)”
  • MP 230 – Monday, June 5, 10:30am – 2:30pm Dr. Simon Prosser will be presenting a poster titled “CMS Analysis of Uniformly 13C-labeled Amino Acids to Identify Authentic Therapeutic Drugs and Protect Against Counterfeits”
  • TP 454 – Tuesday, June 6, 10:30am – 2:30pm Jack Henion will be presenting a poster titled “LC/MS/MS Bioanalytical Protocol for Determining the Degree of Non-Specific Binding in Multi-Well Plates”
  • ThP 429 – Thursday, June 8, 10:30 – 2:30 Lawrence Klecha will be presenting a poster titled “Discovery Ion Current – A Novel Approach to Plot Total Ion Current Real-Time by Enhancing Signal from Newly Detected Ions”

The 100th Annual Canadian Chemistry Conference – A Celebration of Chemistry, May 28 – June 1, Toronto

Join us at the Canadian Chemistry Conference for several days’ worth of education, instrumentation news and networking. Our team will be both exhibiting and giving an oral presentation during the event. Visit booth #603 to view the latest advancements in single-quadrupole mass spectrometry, including:

    • The NEW inert atmospheric solids analysis probe (iASAP) for air sensitive compounds

    • The NEW design of the atmospheric solids analysis probe (ASAP) for solvent-free analysis of liquid and solid samples in less than 30 seconds

    • The NEW volatile APCI source for headspace analysis

We also encourage you to join colleague Lee Collier on Tuesday at 8AM for a poster session on the expression CMS in radiochemistry:

Using a Single Quad Mass Spectrometer in a Radiochemistry Lab
TL Collier, Advion Inc., S Liang and N Vasdev, Massachusetts General Hospital, Harvard Medical School

In the last few years the cost of a single quadrupole mass spectrometer (SQMS) has come down substantially and this reduction in price is making SQMS more affordable to researchers in academic settings and is now finding applications in radiochemistry laboratories. Since these SQMS are becoming available to a wider audience, the possible uses of this type of equipment may not be evident to all users.

The user of a SQMS in a simple LC system can provide basic information however, with the addition of some simple equipment – is it possible to improve the sensitivity and utility of the SQMS? In this presentation, we will focus on radiochemistry laboratories and non-traditional applications of SQMS, and how to modify most systems to obtain further information, including: 1? Identification of possible side products, 2) use of fragmentation ion source settings to obtain further structural information, 3) The determination of the parent ion and possible metabolites in plasma samples, 4) The use of a trap and release system to concentrate dilute samples to allow for the determination of molecular ions and metabolites, 5) quantitation and identification of the parent compound in solutions, 6) development of reformulation methodologies using cold standards – at levels that normally seen in PET or SPECT preparations.

For a first look at the iASAP probe, watch our latest product video now:


“We have the expression linked to an HPLC instrument and it is used as an open access system. The combination of UV purity data along with MS confirmation is incredibly powerful for our chemists. The instrument is networked so our chemists can then process and review data from their desks.”

DYESTUFF ANALYSIS OF CULTURAL HERITAGE OBJECTS by Direct Analysis Probe on a Compact Mass Spectrometer

The scientific investigation of cultural heritage objects is the only access to knowledge about long-gone, ancient societies and their cultural, technological as well as their social  stage of development. In addition, the materials used by our ancestors, e.g. their textiles and the organic dyestuff to colorize these materials, allow researchers to draw some conclusions about cultural exchanges and trading routes. But in-depth knowledge about materials and dyestuff is also of highest importance for proper conservation and restauration of these materials. Specimens, however, are rare and available only in minute amounts. For their investigation preferentially non-destructive or at least minimal invasive methods have to be used.

Compact Mass Spectrometry (CMS) for the Detection and Quantification of Chemical Compounds Related to Cannabis

The cannabinoid makeup of cannabis has significantly changed over the past few decades. Efforts to increase the psychotropic effects of cannabis have resulted in a THC content for current strains of the crop of 30 to 40 percent compared with only 5 percent 30 years ago. Up-regulating the THC content of the plant causes a loss of other cannabinoids the plant is producing. Some of these other cannabinoids, such as CBD, are believed to be responsible for its medical benefits.

Direct Mass Analysis of TLC Plates

Plate ExpressTM is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion’s expression® compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.

NATURAL PRODUCT ANALYSIS Using Compact Mass Spectrometry with Polarity Switching and In-source CID

Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the  pharmaceutical drug development process and consequently half of all currently approved  drugs in the US are based on natural products. It is therefore not surprising that natural product analysis is a field of major interest world wide. Here, we present a simple example  of the added benefits of mass spectrometry in typical natural product analysis workflows based on an alcoholic extract of nutmeg.