Dr. James Reynolds’s group at the University of Loughborough conducts analysis of volatiles by direct breath analysis. The expression CMS allows for highly sensitive dermination of volatile species in breath with no preconcentration.
Reaction Monitoring by Direct Analysis Probe on a Compact Mass Spectrometer
The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP) permits fast analysis of solid and liquid samples and is a simple, faster and lower cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile compounds. ASAP is available as a combined ASAP-APCI source, or existing APCI sources can be easily modified to become dual APCI-ASAP capable.
“Everyone can use it, including students.”
Dr. Frédéric Schmidt’s group at the Institut Curie in Paris had previously given their samples to outside MS services for analysis and had to wait for the results. Incorporating Advion’s expression CMS into their lab allowed them to have a self-service option that everyone could use. And the new workflow sped up their process significantly.
Peptide/Protein Analysis in Less than One Minute
The expression CMS is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.
Direct Mass Analysis from Solid & Liquid Samples
The expression CMS improves the chemist’s workflow by using a direct analysis probe, otherwise known as ASAP® (Atomospheric Solids Analysis Probe), to permit chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.
“The CMS is a very helpful instrument that has shorten product detection times.”
Professor Meng of the Beijing Institute of Technology uses mass spectrometry as a tool for synthetic intermediates. With a large number of products to run, Meng and his team needed to shorten product detection times.
Determination of Emerging Nitrogenous Economic Adulterants in Milk Proteins by HPLC/Compact Mass Spectrometry
The ability to rapidly screen milk ingredients in the manufacturing plants for potential economic adulterants is becoming increasingly important.
A simpler and more cost-effective alternative for frontline screening has been developed.
Utilizing a novel compact mass spectrometer (CMS) for the detection and quantification of chemical compounds related to cannabis
Regardless of the legal status of cannabis and its chemical compounds, both the quality control in legal markets as well as the law enforcement of it’s illegal status require simple, unequivocal and legally defendable analysis methods for the detection and quantification of its major chemical compounds.
Whenever a detector of high selectivity and sensitivity is required, a mass spectrometry based analysis workflow is usually the method of choice and we here demonstrate the analysis of delta9-Tetrahydrocannabinol (THC), Canabidiol (CBD) and Canabinol (CBN) utilizing a novel compact mass spectrometer (expression-S, Advion, NY) coupled to ultra-high performance liquid chromatography (UHPLC) or thin layer chromatography (TLC).
On-Demand Webinar: HRMS, Chemical Modification and Liquid Extraction Surface Analysis for Lipidome Profiling of Colon Adenocarcinom
In this presentation, the development and application of a straightforward and high throughout analysis strategy consisting of high-resolution ‘shotgun’ mass spectrometry (MS), ‘targeted’ tandem mass spectrometry (MS/MS), functional group specific chemical modification and in situ liquid extraction of cell culture samples is described for the comprehensive identification, characterization and quantification of multiple lipid classes from within a colon adenocarcinoma cell line, SW480, and its metastasized derivative, SW620.
Evaluation of a compact mass spectrometer for routine support of pharmaceutical chemistry
Bu X1, Yang J2, Gong X2, Welch CJ3
1Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
2Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
3Analytical Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
The suitability of a recently introduced inexpensive, compact mass spectrometer detector is evaluated for supporting pharmaceutical chemistry investigations. While high performance/high cost MS detectors dominate the marketplace, there is growing recognition of the need for a small, inexpensive MS detector with reduced capabilities for supporting synthetic chemistry investigations, where reduced sensitivity and unit mass resolution are often suitable for solving routine problems. In this study, the fundamental performance characteristics of the recently introduced Advion compact mass spectrometer were evaluated, investigating the use of the instrument for routine product and impurity identification, reaction monitoring, evaluation of potential genotoxic impurities and study of high molecular weight biomolecules. In general, the results of the evaluation show this compact and inexpensive mass spectrometer to be well suited for providing reliable support for pharmaceutical chemistry investigations, with sub-nanogram limit of detection and impurity identification below 0.1% being possible in some instance.