In this webinar, Advion’s Scientific Founder, Jack Henion, Ph.D., will discuss his research using a direct analysis probe coupled with the expression CMS to analyze chemical compounds in Cannabis.
During this webinar you will learn more about:
A simple, sensitive and selective ASAP sample introduction approach to measure the presence and relative quantitative composition of two isobaric compounds, CBDA and THCA, contained in a complex sample such as hemp or cannabis plants or their corresponding extraction products.
Measurement of differences in the relative composition of CBDA and THCA fragment ions originating from the same precursor ion.
Applicability to screening plant and plant product materials such as hemp or marijuana to monitor out-of-specification composition.This webinar was featured by Lab Manager’s Tech Trends webinar series, “Tools for the Cannabis Testing Lab.”
This webinar was hosted by Lab Manager and recorded 4/11/19.
Thanks to the diminishing size and cost of mass spectrometers, coupled with their increasing robustness and ease of use, universities are now starting to furnish their undergraduate chemistry laboratories with this advanced analytic tool.
“My favorite learning environment is the laboratory,” explains Paul A. Flowers, professor of analytical chemistry at University of North Carolina at Pembroke. “I like teaching students fundamentals through bona fide research experiences.” Flowers began using mass spectrometry in the teaching laboratory about six years ago and hasn’t looked back.
Learn more about the integration of mass spectrometry for teaching with this free whitepaper.
The expression® CMS provides essential information quickly and improves the chemist’s workflow by using a direct analysis probe, otherwise known as ASAP® (Atmospheric Solids Analysis Probe) permits chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.
Chemists simply dip the closed end of a glass capillary into the sample of interest (even complex mixtures) or scrape the surface of a solid, and then place the capillary into the CMS for analysis. Clean-up and analysis is a single step. Involatile buffers and salts remain on the capillary ensuring they do not suppress ionization or interfere with the measurement, while the compounds of interest are identified by the CMS.
The Atmospheric Solids Analysis Probe (ASAP™) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation. The inert ASAP (iASAP) is a modification of this technique, allowing easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glove box or Schlenk line to prevent oxidation.
The technique allows a synthetic chemist to perform real-time reaction monitoring by sampling the compound with the special iASAP probe, which is designed to provide access to the sample without disturbing the inert environment, then transferring the sample to the CMS, while continuing to protect it in an inert environment where it is ionized by atmospheric pressure chemical ionization (APCI). Mass Spectra are acquired in seconds.
Volatile Atmospheric Pressure Chemical Ionization (vAPCI) combined with Advion Interchim Scientific’s expression® compact mass spectrometer (CMS) is a fast and easy method to analyze the headspace of a sample with no additional sample prep.
The vAPCI ion source is a simple, powerful tool for gas phase sample analysis. The technique can quickly and confidently identify compounds in air, breath, headspace and other gas samples.
Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.
Advion Interchim Scientific’s Plate Express® is ideal for fast, easy TLC/MS analysis. Coupled with the expression® Compact Mass Spectrometer (CMS), the TLC plate reader allows prep-free sampling and data in less than 30 seconds.
Advion’s direct atmospheric solids analysis probe, otherwise known as ASAP®, permits chemists fast and reliable sample analysis of liquid and solid samples such as reaction mixtures, food samples, natural products and tablets.
Advion’s expression® CMS paired with the Atmospheric Solids Analysis Probe (ASAP®) can quickly and easily be used to screen an unidentified drug mixture in this mobile field testing dramatization.
We demonstrate a cost-effective UHPLC/CMS method for the analysis of chloramphenicol in milk with a detailed discussion of sensitivity, linear response range, carryover and robustness using the Advion expression® Compact Mass Spectrometer (CMS) and Advion AVANT™ UHPLC System.
This application note was adapted from a poster that was presented at the 2019 ASMS Conference on Mass Spectrometry and Allied Topics in Atlanta, GA.
