The ability to effectively screen passengers with minimal personal contact is critical. Ion mobility detectors used at many airports can be inaccurate and provide many false-positives and false-negatives. Advanced Imaging Technology (AIT) screening techniques are very useful for detecting concealed weapons and explosive devices located on passengers and/or in their belongings, however are unable to detect trace amounts of explosive residues.
The expression® Compact Mass Spectrometer (CMS) with an Atmospheric Solids Analysis Probe (ASAP®) is a high performance instrument with a small footprint that allows airports to better screen for explosive residues on passengers and their belongings.
The expression® CMS provides rapid and accurate detection with significantly reduced false-positives and false-negatives than ion mobility instruments.
Aflatoxins (B1, B2, G1, G2) produced by certain fungi (Aspergillus flavus and Aspergillus parasificus) are toxic metabolites which have been associated with various diseases, such as aflatoxicosis, in livestock, domestic animals and humans throughout the world. Many methods can be used for Aflatoxins analysis, including TLC, HPLC, immunoassay, LCMS etc. Of all the methods, the LC/MS method is considered the preferred technique because of its high selectivity and sensitivity. In this presentation, a simple, cost effective LC/CMS analytical approach is described for the determination of Aflatoxins.
Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.
Chemists are tasked with quickly identifying compounds created, ensuring quality of products or evaluating safety. Current techniques are adequate, but not all offer speed, data quality or ease-of-use provided by the expression® Compact Mass Spectrometer (CMS). The expression® CMS with the direct analysis probe (ASAP®) offers chemists the ability to rapidly analyze solids, liquids and powders without tedious and time consuming sample preparation.
A combination of ion-ion interaction chromatography and a compact mass spectrometer presents a cost effective and powerful analysis system for the detection and quantification of amino acids in complex mixtures without the need for extra sample processing steps such as derivatizations.
Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.
Quantitation of Perchlorate by Ion Chromatography with Suppressed Conductivity on the expression CMS
Perchlorate is a synthetic chemical that is used in the manufacture of rocket fuel, fireworks, flares and explosives, and can also be present in bleaches and some fertilizers [1]. The EPA has devised drinking water regulations for Perchlorate to minimize its impact on human health and the environment.
Achieving lower analytical detection limits for Perchlorate in environmental matrices such as drinking water allows regulatory bodies like the EPA make better informed decisions on the degree of contamination of an environmental system, as well as the remedial actions required to limit adverse health and environmental effects.
The expression Compact Mass Spectrometer (CMS) provides lower detection limits and greater selectivity for Perchlorate compared to a conductivity detector (CD). The typical detection limit of a CD is in the mid to high-ppb range, the CMS can detect < 20 ppt.
The expression® CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, low cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile compounds. ASAP® is available as a combined ASAP-APCI source, or existing APCI sources can be easily modified to become dual APCI-ASAP capable.
Register to download the full application note.
The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, faster and lower cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile compounds. ASAP is available as a combined ASAP-APCI source, or existing APCI sources can be easily modified to become dual APCI-ASAP capable.
Register to download the full application note which includes the results of an example analysis.
Q: WHAT IS THE FOCUS OF YOUR LAB’S RESEARCH?
A: My group specializes in developing new methods for pharmaceutical, metabolomic and security applications. In particular, this has involved the analysis of volatiles, either by direct analysis of breath, or through using thermal desorption to extract volatiles from solid or liquid matrices.
Q: WHAT WAS YOUR PREVIOUS WORK FLOW OR CHALLENGES?
A: Previously, we used a quadrupole time-of-flight instrument for volatile analysis. These instruments are not really designed with the analysis of small volatiles in mind and required preconcentration for breath analysis.
Q: WHY DID YOU INCORPORATE THE EXPRESSION CMS INTO YOUR LABORATORY?
A: The expression CMS offers excellent performance in the low m/z range and proved highly sensitive for determining volatile species in breath, requiring no preconcentration. Secondly, the instrument is transportable and can be deployed at the site of sampling giving high sample throughput and real-time measurements.
Q: WHO WOULD YOU RECOMMEND TO PURCHASE THE EXPRESSION CMS?
A: Anyone interested in volatile analysis would find the CMS an excellent instrument for targeted analysis.
