A Handheld Guide: Fun & Easy Mass Spectrometry Experiments for your Teaching Lab

A book of experiments for your students

The expression® CMS (Compact Mass Spectrometer) is the ideal instrument for the teaching lab thanks to its small size, ease of use, and one-click software. This pocket guide of classroom experiments offers students the ability to gain hands-on instrument experience by eliminating complex and difficult sample preparation.

Streamlined Benchtop Mass Spectrometry for the Pharmaceutical Industry

Maximize your analytical spectroscopy workflow in pharmaceutical applications—even with limited space at the bench. This session features innovative solutions for streamlining everyday needs in the lab, including reaction monitoring utilizing fast, prep-free sample introduction techniques for answers in seconds. You will also learn the latest technology in heavy metal analysis, as well as purification tools to maximize your scale-up efforts.

As a viewer, you will learn more about:

  • How to obtain direct mass analysis from TLC plates in seconds
  • Prep-free mass sampling techniques such as a direct analysis probe
  • How heavy metal analysis technology has improved for maximum use in the pharmaceutical lab
  • How scale-up needs can be met with the latest purification technologies

Mass Spectrometry for Teaching Chemistry Undergraduates – The expression® CMS & the SOLATION® ICP-MS

Recorded November 3, 2022: Featured talk in the LCGC Mass Spectrometry Symposium

Join Fadi Abou-Shakra, Director of ICP-MS Portfolio for Advion Interchim Scientific®, as he shares some of the organization’s latest mass spectrometry applications for the teaching lab. This includes student-friendly experiments using a compact single-quadrupole system, as well as simplified ICP-MS applications.

Fadi Abou-shakra started using ICP-MS in 1987 applying it for the analysis of trace elements in biological fluids and has been active in the field of atomic spectroscopy since then. He holds an MSc in Medical Physics and a PhD in Chemistry from the University of Surrey, England. He brings a wealth of experience in ICP-MS as a researcher, customer support specialist and a business manager.

Ready to learn more?

Analytical Sciences Synthesis & Purification: Consumables, Reagents & Instruments

The new edition of our “Analytical Sciences, Synthesis & Purification” catalog is available now! Offering a full suite of innovative products and technologies from Advion Interchim Scientific, this catalog features over 20,000 products ranging from consumables and reagents to instrumentation.

Not only a product resource, the catalog features in-depth scientific information to improve your daily workflow, including sample preparation tips and tricks, analysis technologies such as GC and LC/MS, and help selecting the best consumables for your workflow or purification.

Take advantage of this extensive guide to boost your lab with:

  • 20,000 Products
  • 12 Chapters
  • Technicals Tips
  • New Systems

Setting Up Flash Chromatography in Your Lab: Faster Workflows for Better Purifications

Avoid workflow bottlenecks by streamlining the flash purification process in your lab. This whitepaper can help you identify, reduce, or even eliminate these bottlenecks, tanking your standard operational time from hours to minutes. Learn how essential tools including TLC, a smartphone application and a simple dipping probe for fraction ID offer a novel, systematic approach to help accelerate both synthesis and purification.

Key Objectives:
  • Learn the key tools to setting up a streamlined purification workflow in your lab.
  • Review the most time-consuming processes in a routine flash purification workflow and how to avoid these bottlenecks.
  • Explore how modern technology, including a smartphone application, can assist with method development.

Mass Spec Simplified – Techniques for Reducing Sample Preparation Burden

This webinar features several useful tools to simplify or even eliminate the sample preparation involved prior to mass spectrometry. In this educational session you will learn about several prep-free mass spec techniques that are available, and how to select which method is best for your analysis. Advion will share their perspectives on some of the new tools and protocols to minimize and simplify sample preparation. You’ll learn how to reduce your time in the lab and see your mass spec results in as little as 30 seconds!

As an attendee, you will learn more about:

  • How to select the best tools for sample introduction based on your compound
  • How new tools can reduce or eliminate sample preparation for results in <30 seconds
  • New workflows to maximize your time in the lab by simplifying complex processes

This webinar was presented at the 2023 LabXpo Virtual event by Lab Manager  and LabX, recorded July 20, 2023.

Polymer Defect Engineering – Conductive 2D Organic Platelets from Precise Thiophene-Doped Polyethylene

Authors: Max Planck Institute for Polymer Research, Germany; University of Twente, Netherlands


We developed a simple way to create 2D conductive nanostructures with dielectric cores and conductive surfaces based on polyethylene with in-chain thiophene groups. Generally, thiophene-based polymers show great conductive properties, but exhibit a poor processability. Here, we use the crystallization of a polyethylene chain with precisely distributed thiophene groups as the platform for a self-organization of a lamellar structure. During crystallization, thiophene groups are expelled to the crystal surface. Subsequent copolymerization with 3,4-ethylenedioxythiophene (EDOT) molecules finally yields 2D platelets with a conductive surface. The electric properties of the surface are demonstrated by conductivity measurements. Given the molecular structure of the polymer, it can be assumed that the conductive layer consists of only one monoatomic layer of polymerized thiophene. We thus show a new way to create an ultra-thin, conductive surface on a polymer surface in just a few steps. Hence, the method presented here opens up a wide range of possibilities to produce complex, nanoscale electronic structures for microelectronic applications.

Mass spectrum analysis was obtained by ASAP/CMS using the Advion Interchim Scientific® ASAP® Atmospheric Solids Analysis Probe and expression® Compact Mass Spectrometer (CMS)

Rappsilber Laboratory, Institute of Biotechnology, Technical University Berlin, Germany


A: The Rappsilber Laboratory is interested in studying the machinery of life, in particular protein structures and their interactions in living cells. Determining protein behaviour is crucial for developing new drugs or understanding terrible diseases such as cancer. We are doing this by developing state-of-the-art methods and new chemical tools for crosslinking mass spectrometry (crosslinking-MS), including new crosslinker reagents and crosslinking chemistry. Working on the chemistry-biology interface, our work encompasses chemical synthesis of peptides, fluorophore tagged sensors, peptide- and protein-reactive crosslinking reagents and bioorthogonal metal catalysts.


A: This year (2020) we built a chemistry lab from scratch, here at the Institute of Biotechnology (TU Berlin). We had the opportunity to really think about our work flow requirements and create the most efficient chemical synthesis pipeline for a modern, 21st century, small chemistry laboratory. However, we are a satellite campus, located more than 10 km from the Institute of Chemistry, which meant that we were constrained by the lack of usual chemistry infrastructure. One of the major challenges that we faced here, is that without chemistry-specific analytical capability, we are working almost blind. Every step of chemical synthesis, including reaction monitoring, work-up, purification and final product characterisation required an exhausting and disruptive journey across Berlin!


A: We operate an advanced proteomics facility, with cutting edge, high-precision, high sensitivity mass spectrometers for analysing extremely complex peptide mixtures. But a chemist needs a workhorse, not a Formula 1 car. The Advion Interchim Scientific expression® CMS was a no-brainer. We needed a system that is versatile, compact, easy-to-use, easy-to-maintain (~10 minute calibration), robust and allows fast analysis (result in <30 seconds). This system is all of this, but furthermore it is a delight to use. The ASAP® Direct Analysis Probe works fantastically well for analysis of solids and liquids. Switching between APCI and ESI is so quick and easy. The Plate Express® system makes it a joy to identify reaction products directly from TLC plates, greatly simplifying subsequent purifications. The Plate Express™ also works really well for identifying synthesized peptides from TLC spots. The expression® CMS sits at the heart of our chemistry lab and workflow.


A: We would recommend the Advion Interchim Scientific expression® CMS to literally any research laboratory, big or small. The versatility of the system is truly impressive.

Breaking Through Bottlenecks in Organic Synthesis with a Streamlined Purification Workflow

Successfully completing an organic synthesis involves three typically lengthy, but crucial steps: reaction monitoring, compound identification, and purification. These steps can create bottlenecks in the synthesis, unless a purpose-built, streamlined, and reliable workflow is on hand.
This whitepaper delves into some of the challenges faced by synthetic organic chemists as they navigate compound identification and purification struggles. It also describes how using a workflow that couples thin layer chromatography (TLC) and mass spectrometry (MS) to flash purification can help increase the efficiency of the entire process.

Key Objectives:

  • Understand how a workflow that combines thin-layer chromatography, mass spectrometry, and flash purification can increase the speed and efficiency of an entire organic synthesis process.
  • Learn about prep-free techniques that have become the new standard: scraping TLC spots, developing flash methods and performing long liquid chromatography/MS runs are not necessary with modern instrumentation that is specifically developed to take the prep-work and guess-work out of the purification process.
  • Become informed about a cost-effective, user-friendly benchtop workflow solution for organic compound identification and purification that can save time and money for any lab.