Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the pharmaceutical drug development process and consequently half of all currently approved drugs in the US are based on natural products. It is therefore not surprising that natural product analysis is a field of major interest world wide. Here, we present a simple example of the added benefits of mass spectrometry in typical natural product analysis workflows based on an alcoholic extract of nutmeg.
The expression compact mass spectrometer (CMS) is a novel high performance, easy-to-use single quadrupole mass spectrometer with enhanced scan speed and the ability for on-line polarity switching and in-source fragmentation.
Analysis of the active components of the cannabis sativa plant is required both for law enforcement where these compounds are illegal and also as a tool for product control and optimization in the increasing number of legal markets for cannabis plant products. Whenever simple, unequivocal and legally defensible analysis methods for the detection and quantification of plant metabolites are required, mass spectrometry is the detector of choice.
Here, we present two simple workflows for the analysis of cannabinoids such as the naturally occuring cannabinol (CBN), the psychoactive ingredient of cannabis sativa, tetrahydrocannabinol (THC) and the degradation product cannabidiol (CBD). Both TLC/FIA/CMS for qualitative detection of cannabinoids, as well as HPLC/CMS for the quantitative determination of THC demonstrate the added benefit of compact mass spectrometry in the analysis of natural products.
With decades of mass spectrometry and chemistry expertise, Advion Interchim Scientific has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting.
The Advion Interchim Scientific expression® compact mass spectrometer (CMS) is a fast and easy analytical tool for the organic chemist. Ideal for fast reaction monitoring, the expression® CMS features a single quadrupole that can adapt to multiple ionization sources in seconds, including both ESI and APCI. The mass spectrometer works in a variety of applications, including food and beverage, pharmaceutical, biomedical, peptides and proteins, drug discovery and more. The expression® CMS offers a variety of novel sampling techniques, including:
- Direct mass analysis of TLC plates in 30 seconds at the push of a button with Plate Express™
- One-touch analysis of solids and liquid samples with the ASAP® probe
- LC/CMS
- Many more options and configurations to suit your needs
Learn more about the different sample techniques available with the expression® CMS, including fast assay methods for liquids, solids, gases, and even air-sensitive compounds.
Fill out the form to download the full expression® CMS brochure now.
The ability to effectively screen passengers with minimal personal contact is critical. Ion mobility detectors used at many airports can be inaccurate and provide many false-positives and false-negatives. Advanced Imaging Technology (AIT) screening techniques are very useful for detecting concealed weapons and explosive devices located on passengers and/or in their belongings, however are unable to detect trace amounts of explosive residues.
The expression® Compact Mass Spectrometer (CMS) with an Atmospheric Solids Analysis Probe (ASAP®) is a high performance instrument with a small footprint that allows airports to better screen for explosive residues on passengers and their belongings.
The expression® CMS provides rapid and accurate detection with significantly reduced false-positives and false-negatives than ion mobility instruments.
Aflatoxins (B1, B2, G1, G2) produced by certain fungi (Aspergillus flavus and Aspergillus parasificus) are toxic metabolites which have been associated with various diseases, such as aflatoxicosis, in livestock, domestic animals and humans throughout the world. Many methods can be used for Aflatoxins analysis, including TLC, HPLC, immunoassay, LCMS etc. Of all the methods, the LC/MS method is considered the preferred technique because of its high selectivity and sensitivity. In this presentation, a simple, cost effective LC/CMS analytical approach is described for the determination of Aflatoxins.
Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.
Chemists are tasked with quickly identifying compounds created, ensuring quality of products or evaluating safety. Current techniques are adequate, but not all offer speed, data quality or ease-of-use provided by the expression® Compact Mass Spectrometer (CMS). The expression® CMS with the direct analysis probe (ASAP®) offers chemists the ability to rapidly analyze solids, liquids and powders without tedious and time consuming sample preparation.
A combination of ion-ion interaction chromatography and a compact mass spectrometer presents a cost effective and powerful analysis system for the detection and quantification of amino acids in complex mixtures without the need for extra sample processing steps such as derivatizations.
Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.
Quantitation of Perchlorate by Ion Chromatography with Suppressed Conductivity on the expression CMS
Perchlorate is a synthetic chemical that is used in the manufacture of rocket fuel, fireworks, flares and explosives, and can also be present in bleaches and some fertilizers [1]. The EPA has devised drinking water regulations for Perchlorate to minimize its impact on human health and the environment.
Achieving lower analytical detection limits for Perchlorate in environmental matrices such as drinking water allows regulatory bodies like the EPA make better informed decisions on the degree of contamination of an environmental system, as well as the remedial actions required to limit adverse health and environmental effects.
The expression Compact Mass Spectrometer (CMS) provides lower detection limits and greater selectivity for Perchlorate compared to a conductivity detector (CD). The typical detection limit of a CD is in the mid to high-ppb range, the CMS can detect < 20 ppt.
