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Recorded November 3, 2022: Featured talk in the LCGC Mass Spectrometry Symposium Join Fadi Abou-Shakra, Director of ICP-MS Portfolio for Advion Interchim Scientific®, as he shares some of the organization’s latest mass spectrometry applications for the teaching lab. This includes student-friendly experiments using a compact single-quadrupole system, as well as simplified ICP-MS applications. Fadi Abou-shakra started …

The new edition of our “Analytical Sciences, Synthesis & Purification” catalog is available now! Offering a full suite of innovative products and technologies from Advion Interchim Scientific, this catalog features over 20,000 products ranging from consumables and reagents to instrumentation. Not only a product resource, the catalog features in-depth scientific information to improve your daily …

Institute of Food Research, Genome Analysis Center, Aix-Marseille University, University of East Anglia Abstract We previously identified and characterized an intramolecular trans-sialidase (IT-sialidase) in the gut symbiont Ruminococcus gnavus ATCC 29149, which is associated to the ability of the strain to grow on mucins. In this work we have obtained and analyzed the draft genome …

USDA, University of Connecticut Abstract Research methods that predict Fe bioavailability for humans can be extremely useful in evaluating food fortification strategies, developing Fe-biofortified enhanced staple food crops and assessing the Fe bioavailability of meal plans that include such crops. In this review, research from four recent poultry (Gallus gallus) feeding trials coupled with in …

University of Florida, USDA, Kansas State University Abstract Currently, the global citrus production is declining due to the spread of Huanglongbing (HLB). HLB, otherwise known as citrus greening, is caused by Candidatus Liberibacter asiaticus (CLas) and is transmitted by the Asian citrus psyllids (ACP), Diaphorina citri Kuwayama. In this study, we investigated the micro- and …

Gujarat University Abstract Synthesis of new and desired compounds has an everlasting demand. The present work emphasizes on the one pot, three component microwave assisted synthesis of novel ethyl 2-methyl-4-(pyridin-2-yl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylate derivatives by the reaction of 2-aminobenzothiazole derivatives with Pyridine 2-aldehyde and Ethyl acetoacetate in the presence of PdCl2 as an expeditious catalyst under solvent-free condition. …

Gujarat University Abstract A concise, facile and straightforward synthetic protocol has been described for the preparation of 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives by a one-pot, three-component reaction of ethyl acetoacetate, hydrazine hydrate, aryl aldehydes and malononitrile in glycerol as a green and reusable reaction media under catalyst free condition. The corresponding 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitriles have been obtained with good to …

University of Durham Abstract The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including several carbon-carbon bond forming processes. It is therefore highly desirable to determine optimum conditions for the …

Western Washington University Abstract Sortase‐catalyzed transacylation reactions are widely used for the construction of non‐natural protein derivatives. However, the most commonly used enzyme for these strategies (sortase A from Staphylococcus aureus) is limited by its narrow substrate scope. To expand the range of substrates compatible with sortase‐mediated reactions, we characterized the in vitro substrate preferences …

Lyon College, University of Rhode Island Abstract MOLSTR, Accepted manuscript. doi:10.1016/j.molstruc.2016.05.075   We have synthesized a trio of gallium complexes bearing 9-anthraldehyde thiosemicarbazones. The complexes were assessed for their anticancer activity and their biophysical reactivity was also investigated. The results of docking studies with DNA, ribonucleotide reductase and human serum albumin, however showed that the …

Xention Limited, United Kingdom; University of Ljubljana, Slovenia Abstract The rodent neuroblastoma cell line, ND7-23, is used to express voltage-dependent sodium (Nav) and other neuronal ion channels resistant to heterologous expression in Chinese hamster ovary (CHO) or human embryonic kidney (HEK) cells. Their advantage is that they provide endogenous factors and signaling pathways to promote …

Mokpo National University, Gachon University, Hanyang University, Gachon Medical Research Institute, South Korea; University of Bremen, Germany Abstract G protein-coupled receptor (GPR) 119 is expressed in pancreatic β-cells and intestinal L cells, and is involved in glucose-stimulated insulin secretion and glucagon-like peptide-1 (GLP-1) release, respectively. Therefore, the development of GPR119 agonists is a potential treatment for …

Gujarat University Abstract A library of thiosemicarbazide hybrid 2-(aldo-polyhydroxyalkyl)benzimidazole derivatives have been designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds have been elucidated with the aid of elemental analysis, IR, mass and 1H NMR spectral data. These novel synthesized compounds have been evaluated for their antibacterial activity against two gram-positive …

Karlsruhe Institute of Technology Abstract The preparation of cross-linked nanosheets with 1–2 nm thickness and predefined shape was achieved by lithographic immobilization of trimethacryloyl thioalkanoates onto the surface of Si wafers, which were functionalized with 2-(phenacylthio)acetamido groups via a photoinduced reaction. Subsequent cross-linking via free radical polymerization as well as a phototriggered Diels–Alder reaction under …

Gujarat University Abstract A convenient one-pot, multi-component and solvent free procedure for the preparation of substituted 2-amino-5-aryl-1,3,4-oxadiazoles has been achieved. The method is a significant improvement over previously reported synthesis. Reaction of acid chlorides with hydrazine hydrate and isothiocynates under microwave-irradiation (MWI) afforded the corresponding 1,3,4-oxadiazole derivatives in high yields with high purity. All synthesized …

Guru Ghasidas University, University of South Dakota A one-pot practical, efficient, and environmentally benign multicomponent synthesis of 4H-pyrans and polysubstituted aniline derivatives of biological, pharmacological, and optical applications has been developed using a very mild, neutral, and reusable silica nanoparticles as catalyst. The 4H-pyran derivatives were synthesized by a three component reaction of an aldehyde, …

Kyungpook National University, Dankook University, Ulsan National Institute of Science and Technology, South Korea; Icahn School of Medicine at Mount Sinai, United States Abstract Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer’s disease (AD). However, the mechanism underlying this activity was unexplored. Here …

Authors: Japan Bioindustry Association, Advanced Industrial Science and Technology, Japan Highlights Deacetylation of glycopeptide with an esterase prevents base-induced side reactions, b-elimination, and epimerization An esterase from B. subtilis was utilized for Deacetylation of sugar hydroxyl groups on glycopeptide synthesis Deacetylation with an esterase and glycosylations with glycosyltransferases were accomplished in one-pot Abstract Glycopeptides are fragments …

The Advion Interchim Scientific suite of systems and consumables allows users to harness the power of mass spectrometry, flash chromatography, prep LC and more. Simple and robust, download our brochure to learn more about: The Advion Interchim Scientific expression® compact mass spectrometer (CMS): A fast and easy analytical tool for the organic chemist. Ideal for fast …

Horbaczewskyj, Christopher Stefan (2019) Monitoring, Modelling and Optimisation of Continuous Flow Reactions Using On-line Mass Spectrometry. PhD thesis, University of Leeds. Abstract An on-line mass spectrometry method has been developed to monitor, model and optimise continuous flow reactions. This method makes use of dual-piston pumps, tubular reactor block, Vici sample actuator, an Advion expression Compact Mass …

Thanks to the diminishing size and cost of mass spectrometers, coupled with their increasing robustness and ease of use, universities are now starting to furnish their undergraduate chemistry laboratories with this advanced analytic tool. “My favorite learning environment is the laboratory,” explains Paul A. Flowers, professor of analytical chemistry at University of North Carolina at …

During this webinar you will learn more about: A new type of mass spectrum: the Delta Spectrum (ΔS). The patented ΔS is able to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z. How to easily find adducts, dimers, fragments, side-reactions and other unexpected compounds at the click of …

J. S. Hanas, J. R. Hocker, G. Ramajayam, V. Prabhakaran, V. Rajshekhar, A. Oommen, J. J. Manoj, M. P. Anderson, D. A. Drevets, H. Carabin Neurocysticercosis is associated with epilepsy in pig-raising communities with poor sanitation. Current internationally recognized diagnostic guidelines for neurocysticercosis rely on brain imaging, a technology that is frequently not available or …

Bring mass spectrometry into your classroom for remote or on-site learning with a training course for the expression® Compact Mass Spectrometer (CMS). Advion offers an affordable MS teaching package that includes: A compact, easy-to-use benchtop mass spectrometer for both students and researchers Recorded lectures and video lab content Lecture slides to share or adapt to your own teaching style …

Integrated Solutions for Food Authenticity, Characterization and Safety with the expression® Compact Mass Spectrometer, AVANT® (U)HPLC and SOLATION® ICP-MS  Your integrated laboratory solution for comprehensive testing of food, ingredients and natural products. Advion offers a full suite of analytical instrumentation for characterization, screening and purity determination, including: expression® CMS – The expression® Compact Mass Spectrometer (CMS) offers …

Integrated Solutions for Potency and Safety with the expression® Compact Mass Spectrometer and SOLATION® ICP-MS Outfit your lab with Advion Interchim Scientific’s line of custom cannabis solutions, including the expression® Compact Mass Spectrometer (CMS), the SOLATION® ICP-MS, and a customizable (U)HPLC solution. Your Complete Lab Solution: Advion Interchim Scientific provides integrated laboratory solutions for comprehensive cannabis …

University of Oklahoma Health Science Center, Christian Medical College Abstract Minimally invasive and low-cost aids for diagnosing neurocysticercosis epilepsy could improve treatment of neurocysticercosis. The goal of this study was to test the extent to which patients with neurocysticercosis epilepsy, epilepsy of unknown etiology, idiopathic headaches and among different types of neurocysticercosis lesions could be …

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective …

Maria Baskin, Natalia Fridman, Monica Kosa, Galia Maayan We describe the construction of synthetically challenging heteroleptic complexes by capitalizing on the solubility properties of their corresponding favored homoleptic complexes. We demonstrate that the formation of a heteroleptic Cu2+ complex based on 2,2′:6′,2′′-terpyridine (Terpy) and 8-hydroxyquinoline (HQ) is not possible due to the insolubility of (HQ)2Cu2+. …

Sung Yong Byeon, Ji Han Kim, Jun Yeob Lee CN-modified host materials, 9-(2-(9-phenyl-9H-carbazol-3-yl)phenyl)-9H-carbazole-3-carbonitrile (o-CzCN) and 9-(3-(9-phenyl-9H-carbazol-3-yl)phenyl)-9H-carbazole-3-carbonitrile (m-CzCN), which can improve the external quantum efficiency and lifetime of both blue phosphorescent and thermally activated delayed fluorescent (TADF) emitters were developed. A molecular design approach to stabilize the molecular structure and reduce the energy gap produced two …

Marie Monestier, Dimitrios Latousakis, Andrew Bell, Sandra Tribal, Louise E. Tailford, Ian J. Colquhoun, Gwenaelle Le Gall, Hai Yu, Xi Chen, Martin Rejzek, Simone Dedola, Robert A. Field, Nathalie Juge Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases). A facile one-pot two-enzyme approach has been established for the synthesis …

Additi Roy Chowdhury, Biswajit Gopal Roy, Saibal Jana, Thomas Weyhermuller, Priyata Banerjee Novel colorimetric hydrazine-functionalized Schiff base chemoreceptor [N1N3bis(perfluorobenzylidene)isophthalahydrazide] NBPBIH has been prepared for selective detection of F−. In this receptor more NH and CN units are incorporated for better colorimetric responses as compared to systems having lesser number of such units. NBPBIH turns from …

Additi Roy Chowdhury, Amita Mondal, Biswajit Gopal Roy, Jagadeesh C. Bose K, Sudit Mukhopadhyaye and Priyabrata Banerjee Two novel hydrazine based sensors, BPPIH (N1, N3-bis(perfluorophenyl)isophthalohydrazide) and BPBIH (N1′, N3′-bis(perfluorobenzylidene)isophthalohydrazide), are presented here. BPPIH is found to be a highly sensitive pH sensor in the pH range 5.0 to 10.0 in a DMSO–water solvent mixture with …

Shared live at the 254th ACS National Meeting in Washington, D.C. – John Matson, Ph. D., Matson Research Group on Macromolecular and Supramolecular Chemistry, Assistant Professor, Virginia Tech. Listen to the recorded workshop session highlighting the role of H2S in the human body and how compact mass spectrometry is used to assay peptides via direct injection for reaction …

Introducing a new type of mass spectrum, available exclusively in the Advion Peak Express™ software suite: the Delta Spectrum (ΔS). The ΔS is available with the expression® compact mass spectrometer (CMS) to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z in advance. With the Peak Express™ software featuring ΔS, …

The data collected from the analysis on the portable Advion CMS were treated in exactly the same way as the data collected from the Waters LCT and although the mass resolution and sensitivity of the two instruments is different the same clustering patterns were seen in the PCA scores plots. The PCA loadings plots also …

Quant Express, an addition to Advion’s user-friendly Mass Express 4.0 software suite, features quantitation to create a fully integrated software system for expression CMS users.

Introducing a new type of mass spectrum, available exclusively in the Advion Peak Express™ software suite: the Delta Spectrum (ΔS). The ΔS is available with the expression compact mass spectrometer (CMS) to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z in advance. With the Peak Express™ software, you …

Turn your expression® CMS into a high resolution, exact mass instrument in its ability to provide elemental formulae. TAMI uses accurate centroiding and mass correction algorithms to provide a more accurate mass assignment.  In combination with isotope abundance analysis and careful consideration of chemical valence rules this provision of elemental formulae with a high level …

This webinar examines the workflow of a medicinal chemist as they utilize compact mass spectrometry techniques for drug discovery and disease prevention.

The Montclair University team utilizes the Advion CMS in their undergraduate lab. Essential in the research-focused curriculum, the team was able to purchase the cost effective, small-footprint system to grow their lab capabilities. They later added an APCI module for their growing needs.

The CheMS user interface simplifies the mass spectrometry experience and makes it more accessible in chemistry and biochemistry laboratories. This allows the chemist to obtain optimal data without needing to be an expert in mass spectrometry. Available with the Advion expression® compact mass spectrometer (CMS) is a fast and easy tool that is ideal for …

University of Cambridge Abstract We have developed a modular software system that enables researchers to monitor and control chemical reactions via the Internet, using any device from any location in the world. It facilitates the automation of synthetic procedures and is able to autonomously self-optimize reaction parameters to find the best conditions meeting customizable, multicomponent …

With decades of mass spectrometry and chemistry expertise, Advion Interchim Scientific has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting. The Advion Interchim Scientific expression® compact …

Quantitation of Perchlorate by Ion Chromatography with Suppressed Conductivity on the expression CMS Perchlorate is a synthetic chemical that is used in the manufacture of rocket fuel, fireworks, flares and explosives, and can also be present in bleaches and some fertilizers [1]. The EPA has devised drinking water regulations for Perchlorate to minimize its impact …

Via Direct Injection using a Compact Mass Spectrometer with extended mass range (CMSL) The CMSL is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — ideal for large molecule applications such as the analysis of proteins. Its small footprint makes it the instrument …

The expression compact mass spectrometer (CMS) is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.

The rapid identification of radiolabeled compounds would clearly be beneficial for applied clinical and preclinical tracers used for imaging with positron emission tomography (PET). The limited uptake of mass spectrometry in the imaging field has been due to several factors including concerns regarding adequate sensitivity, instrument footprint in the highly constrained space requirements for the …

Ultra (high) performance liquid chromatography (UPLC/UHPLC) is a relatively new technique, and is valued for its speed, efficiency and the quality of information provided. Many synthetic and medicinal chemistry laboratories are moving to this process to improve their workflows and save time.

The expression CMS was developed with the chemist’s objectives and laboratory workflow in mind. Organic, Natural Product and Peptide chemists utilize many techniques to determine the progress, yield and purity of their reactions.

Goa College of Pharmacy Abstract The present study was undertaken to carry out phytochemical investigation of the ethanolic extract of the stem bark of Terminalia tomentosa Roxb (ex DC) Wight & Arnbelonging to the family Combreteaceae. The plant is known in Sanskrit as Asana, in English as Black murdah, in Hindi as Asan, Saj, Sain …

A novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions. Medical chemists are routinely faced with personally over a hundred new chemical entities (NCE’s) each year for testing as future pharmaceutical drug candidates. The goal is to prepare a high yield, relatively pure product via an optimized synthetic route.

Advion demonstrates a novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions employing either LC/MS or flow injection analysis (FIA).