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This Webinar was originally presented March 7, 2024 on LabRoots.com ABSTRACT The latest purification systems are not like those of the past — you do not have to choose between flash and PrepLC. Now, you can have both with the ability to decide your needs with one user-friendly system. In this webinar, you will learn …

This Webinar was originally presented November 9, 2023 on LabRoots.com ABSTRACT In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover: How to select the ideal purification solution for your lab’s specific needs How …

This whitepaper explores the use of alternative chromatography technology for faster, more efficient analysis over traditional LC/MS runs. Plate Express™ is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, combined with the Advion Interchim Scientific® expression® CMS (Compact Mass Spectrometer) creating a technique known as TLC/CMS. Using …

Oligonucleotides have gained significant attention in biopharmaceutical development due to their ability to modulate gene or protein expression. This application note aims to demonstrate the HPLC/UV analysis of multiple oligo samples and utilize HPLC/CMS analysis to determine their molecular weight.

In this application note, we use whey protein isolate and two casein macro peptides as an example to demonstrate the isolation and purification of bioactive peptide components with a system comprised of a puriFlash® 5.250 prepLC coupled online to an expression® CMS detector.

A book of experiments for your students The expression® CMS (Compact Mass Spectrometer) is the ideal instrument for the teaching lab thanks to its small size, ease of use, and one-click software. This pocket guide of classroom experiments offers students the ability to gain hands-on instrument experience by eliminating complex and difficult sample preparation.

In this application note, we demonstrate a complete solution for the synthesis, purification, and quantitation of Gd(III)-DOTA, an ionic imaging contrast agent with better chemical stability and lower toxicity compared to the currently used Gd-(DTPA).

In this application note, we present a fast method for routine analysis of small volume blood samples for key toxic and essential elements using the Advion Interchim Scientific® SOLATION® Inductively Coupled Plasma Mass Spectrometer (ICP-MS) using a simple “dilute and shoot” sample preparation.

Iohexol is a widely used non-ionic imaging agent that improves contrast for x–ray analysis. Its low osmolality allows for a rapid clearance via the kidney, preventing reabsorption and further metabolization. This makes iohexol a compound with a better safety profile compared to other imaging agents. In this application note, a simple and accurate HPLC-CMS method …

Recorded February 2, 2023: LIVE Location, the 2023 European Winter Conference on Plasma Spectrochemistry Speakers: Janez Ilaš, Ph. D., Professor, University of Ljubljana Fadi Abou-Shakra, Director of Advion Interchim Scientific® ICP-MS Portfolio Join Advion Interchim Scientific® with guest speaker from the University of Ljubljana, Faculty of Pharmacy, to learn more about a new novel sample …

Maximize your analytical spectroscopy workflow in pharmaceutical applications—even with limited space at the bench. This session features innovative solutions for streamlining everyday needs in the lab, including reaction monitoring utilizing fast, prep-free sample introduction techniques for answers in seconds. You will also learn the latest technology in heavy metal analysis, as well as purification tools …

In this application note we present a method for routine analysis of 21 elements using the Advion Interchim Scientific® SOLATION® Inductively Coupled Plasma Mass Spectrometer (ICP-MS). A group of unknown soil samples and a CRM were digested using EPA 3051a and analyzed according to method 6020a requirements.

In this application note, we show how Cyanidin-3-glucoside can be extracted from black rice and purified with a prepLC/Flash system. The amount and purity of Cyanidin-3-glucoside was measured utilizing a certified reference standard.

In this application note, a method to separate and purify green tea catechins with preparative liquid chromatography (Prep-LC) using the puriFlash® 5.250 system is demonstrated. An additional HPLC-UV-MS method is also demonstrated for compound confirmation and purity analysis.

In this application note, a method to separate and purify 3 curcuminoids from turmeric powder using thin layer chromatography (TLC) with mass spectrometry and flash chromatography is demonstrated.

In this application note, we describe methods of isolating natural products from green tea and turmeric powder by mass-directed fraction collection during flash chromatography and preparative LC. For demonstration purposes, the isolated compounds were then additionally confirmed by Atmospheric Solids Analysis Probe (ASAP®) MS or HPLC-MS.

Recorded November 3, 2022: Featured talk in the LCGC Mass Spectrometry Symposium Join Fadi Abou-Shakra, Director of ICP-MS Portfolio for Advion Interchim Scientific®, as he shares some of the organization’s latest mass spectrometry applications for the teaching lab. This includes student-friendly experiments using a compact single-quadrupole system, as well as simplified ICP-MS applications. Fadi Abou-shakra started …

The new edition of our “Analytical Sciences, Synthesis & Purification” catalog is available now! Offering a full suite of innovative products and technologies from Advion Interchim Scientific, this catalog features over 20,000 products ranging from consumables and reagents to instrumentation. Not only a product resource, the catalog features in-depth scientific information to improve your daily …

Ask the Expert Webinar Presented live November 2, 2022 Step inside the Parasram Lab at New York University for a look at some of their latest research. In this webinar, Professor Marvin Parasram will discuss data from his laboratory’s recent publication, “Anaerobic Heteroatom Transfer Reactions Using Photoexcited Nitroarenes.” The research features developments on the anaerobic …

Recorded May 5, 2022. Join Daniel Kim, Ph.D., Assistant Professor ​Organic, Inorganic, Biological, from Temple University, as he presents several new methodologies developed for reaction discovery. In this webinar, you will learn: How to develop a fast and modular workflow for reaction discovery on a budget The advantages to using Advion-Interchim Scientific suite of instruments …

Lab Manager Ask the Expert Webinar. Recorded September 7, 2022 Maximize your workflow—even with limited space at the bench. This webinar features innovative solutions for streamlining the chemists’ everyday needs, including reaction monitoring, purification, fraction collection, and evaporation. No matter what your application, the session will address some of the most common bottlenecks and how …

Lab Manager Ask the Expert Webinar. Recorded September 15, 2022 Out of your element? Don’t be! This webinar features innovative cannabis and blood applications, plus tips and tricks to maximize throughput, precision, and sensitivity when utilizing ICP-MS technology. Performed using the Advion Interchim Scientific SOLATION® ICP-MS featuring a state-of-the-art sample introduction from Glass Expansion, this …

In this application note, a simple, cost-effective UHPLC/UV method is introduced for analysis of cannabinoids in edible samples (examples shown are gummy bears, chocolates and cookies) using the Advion Interchim Scientific AVANT™ UHPLC/PDA System.

 In this application note, a simple, cost-effective UHPLC/UV method is presented for the quantitation of cannabinoids using an Advion Interchim Scientific AVANT™ UHPLC system. With simple sample preparation, requiring only dilution, the method can be used for the analysis of plant material, oils, distillates and isolates.

Recorded June 15, 2022. Join Christopher Thomson, Researcher at Heriot-Watt University, as he shares his work expanding the tool kit of automated flow synthesis with the development of in-line flash chromatography purification. In this webinar, you will learn: An introduction to flow chemistry and in-line purification technologies. An overview of prior continuous chromatography methods, their …

In this application note, we describe a novel method to perform the continuous isolation of flow synthesis products from residual starting materials, catalysts or by-products to expedite chemical discovery. A promising new approach is highlighted here, featuring the Advion Interchim Scientific puriFlash® 5.250 preparative LC system. The first results of our cooperation with the VilelaLAB …

Helium shortages are not new – annually, scientists see the cost of helium rise and fall like the stock market. Except this isn’t just a financial impact. Global helium shortages threaten to derail research and essential industry functions, taking down GC and high-field NMR instruments, bringing a once state-of-the-art lab down to a bare-bones facility. …

Avoid workflow bottlenecks by streamlining the flash purification process in your lab. This whitepaper can help you identify, reduce, or even eliminate these bottlenecks, tanking your standard operational time from hours to minutes. Learn how essential tools including TLC, a smartphone application and a simple dipping probe for fraction ID offer a novel, systematic approach …

The NEW puriFlash® XS-Vap, your intuitive laboratory evaporator. X-tra compact. X-tra intuitive. X-tra efficient. X-tra evaporation. Reduce evaporation time and gas consumption with the most advanced evaporator on the market. The puriFlash® XS-Vap offers an extensive range of benefits over the competition: Compact and robust Dedicated to solvent evaporation & concentration Up to 90 samples in parallel …

In this application note, we used the Advion Interchim Scientific puriFlash® 5.250 to purify five active ingredients found in over-the-counter (OTC) and prescription drugs including caffeine, glafenine, ketoprofen, flavone, and fenofibrate, by a preparative purification workflow. The compounds were then confirmed using the expression® compact mass spectrometer.

The compound synthesis, purification, and confirmation processes often present challenges. From ensuring successful synthesis of your product, setting up a flash purification method, and finally confirming ID of fractions, the lengthy workflow can be time consuming and repetitive. This webinar will provide a foundation for flash purification processes and will showcase a novel workflow concept …

Lab Manager Tech Trends Webinar. Recorded August 11, 2021. This webinar features the Interchim PuriFlash® flash purification and preparative HPLC system and demonstrates separation of natural products, purification of specific target molecules and the combination of mass spectrometry detection of the same both for product confirmation and mass directed fraction collection using an Advion expression® …

In this exclusive webinar, our cannabis instrumentation experts will share information about solutions that relieve the purification bottleneck for processors. This 15-minute on-demand session will cover: Pesticide remediation and dewaxing THC remediation Minor cannabinoid purification In-house analytical System and Consumable options

This 159-page educational eBook is a comprehensive manual on high-throughput purification – from the theory and principles of chromatography through to method development and column selection. This valuable book offers an incredible opportunity for both beginners and experts alike to learn more about the science of chromatography and can improve your workflow and productivity. Chapter …

This webinar features several useful tools to simplify or even eliminate the sample preparation involved prior to mass spectrometry. In this educational session you will learn about several prep-free mass spec techniques that are available, and how to select which method is best for your analysis. Advion will share their perspectives on some of the …

With over 20 years of mass spectrometry and chemistry expertise, Advion Interchim Scientific® has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting. The Advion Interchim …

In this note, a quick and direct screening method for the detection of illicit drugs on paper currency is introduced using the Touch Express™ Open Port Sampling Interface (OPSI) on the Advion expression® Compact Mass Spectrometer (CMS). A range of paper currency bills from different countries were analyzed for traces of illicit drugs.

In this application note, both the purification and analytical processes for THC remediation using the Interchim ITM-5015 and Advion AVANT™ HPLC-UV systems are shown to form a complete solution for THC remediation in the hemp industry.

Successfully completing an organic synthesis involves three typically lengthy, but crucial steps: reaction monitoring, compound identification, and purification. These steps can create bottlenecks in the synthesis, unless a purpose-built, streamlined, and reliable workflow is on hand. This whitepaper delves into some of the challenges faced by synthetic organic chemists as they navigate compound identification and …

The compound synthesis, purification and confirmation processes often present challenges. From ensuring successful synthesis of your product, setting up a flash purification method, and finally confirming ID of fractions, the lengthy work flow can be time consuming and repetitive. This webinar will provide a foundation for flash purification processes, and will showcase a novel work …

Mass spectrometry is an analytical technique used to determine the mass-to-charge ratio of ions in a sample and therefore the sample composition. This method is used across many industries including food and beverage, environmental monitoring, and clinical. There are many features of mass spectrometers that must be considered before purchasing such as the required mass …

Environmental monitoring is vital to understanding the world around us. Air quality, water, and soil testing all provide valuable information about an environment’s status. Tools and technologies for environmental monitoring can be used to evaluate the sanitation of a food and beverage lab or to monitor an ecosystem’s recovery after an oil spill. Join Lab …

Lab Manager Tech Trends Webinar. Recorded June 25, 2020. Food and beverage labs use techniques from other disciplines such as microbiology, environmental monitoring, and analytical chemistry to test for food and beverage contaminants. Unlike these disciplines, the food and beverage industry is highly regulated and therefore food and beverage labs have very specific needs. Join …

This is one from a set of two application notes. In this application note, we determine the purity of collection of a small (0.2%) impurity in a concentrated sample mix by mass-directed fraction collection using supercritical fluid chromatography (SFC) coupled with the Advion expression Compact Mass Spectrometer (CMS). For the other application note on the …

A simple, sensitive and selective ASAP® sample introduction approach to measuring the presence of two isobaric compounds, CBDA and THCA, contained in a complex sample such as hemp or cannabis plants or their corresponding extraction products. Measurements are made of differences in the relative composition of CBDA and THCA fragment ions originating from the same …

Review new data and tips for using the Advion Interchim Scientific SOLATION® inductively coupled plasma mass spectrometer (ICP-MS) in the cannabis and hemp testing lab, and factors that affect heavy metals in cannabis and hemp. This ebook was created with Spectroscopy and released June 2020.

The combination of the Advion Interchim Scientific expression® CMS and puriFlash® flash chromatography technologies speed up the synthesis, purification and characterization of a compound. Using the Advion Interchim Scientific expression® Compact Mass Spectrometer, the Plate Express™ TLC Plate reader, the ASAP® Atmospheric Solids Analysis Probe, and the puriFlash® XS520 flash purification system, it is now possible to execute …

Dr. Jack Henion presents the possibility of using the Advion Interchim Scientific expression® Compact Mass Spectrometer (CMS) for ‘roadside breath testing’ of THC DRUID (driving under the influence of drugs) with the use of a small plastic breath collection device from Breath Explor of Uppsala, Sweden. This device serves as a simple, acceptable collection device for …

Patulin is a mycotoxin that is a common contaminant in food and animal feed, especially in apple products. The potential health risk of patulin to humans led to the establishment of action levels in foodstuffs. The EU, WHO and US FDA defined maximum levels of patulin in fruit juices. The EU also has specific regulations …

The compound synthesis, purification and confirmation process often presents challenges throughout. From ensuring successful synthesis of your product, setting up a flash purification method, and finally confirming ID of fractions, the lengthy work flow can be time consuming and repetitive. In this application note, we demonstrate how the combination of Advion and Interchim technologies speed …

The combination of the Advion Interchim Scientific® expression® CMS puriFlash® flash chromatography technologies speed up the synthesis, purification and characterization of a compound. Watched the video and ready to learn more? View More TLC to Flash Details

In this application note, the Advion Interchim Scientific expression® Compact Mass Spectrometer (CMS) with volatile APCI (vAPCI) is used to analyze volatile compounds present during the fermentation of homebrewed beer by Stephanie Rankin Turner of Loughborough University. The complex flavor of beer is primarily a result of the ingredients used, the brewing method, and conditions …

In this study, we used the Advion Interchim Scientific SOLATION® ICP-MS and a microwave digestion system to digest and analyze hemp samples using the validation methods described in USP General Chapter <233>. The sensitivity, ability to handle complex matrices, and the ability to remove interferences with a helium collision cell makes this the ideal system …

Learn Mass Spectrometry: For a limited time, access our free curriculum from Dr. Jack Henion, global leader and educator for Mass Spectrometry and LC/MS Take advantage of this educational opportunity to learn from the master, Dr. Henion, Cornell Emeritus Professor, who will guide you through basic principles to more advanced techniques. This lecture series offers a …

The Advion Interchim Scientific suite of systems and consumables allows users to harness the power of mass spectrometry, flash chromatography, prep LC and more. Simple and robust, download our brochure to learn more about: The Advion Interchim Scientific expression® compact mass spectrometer (CMS): A fast and easy analytical tool for the organic chemist. Ideal for fast …

Bring mass spectrometry into your classroom for remote or on-site learning with a training course for the expression Compact Mass Spectrometer (CMS). Advion offers an affordable MS teaching package that includes: A compact, easy-to-use benchtop mass spectrometer for both students and researchers Recorded lectures and video lab content Lecture slides to share or adapt to your own teaching style …

The recent outbreak of severe lung injury is allegedly tied to the presence of Vitamin E Acetate (VEA) in vaping-related products after VEA was found in lung fluid samples of patients with vaping-related lung illness (EVALI). Calling for regulatory control, Washington, Colorado and Ohio have already banned the use of VEA in e-juices at the state …

In this Lab Manager webinar, Dr. Daniel Eikel, Advion Director of Product Applications and Customer Service reviews the use of the Advion expression Compact Mass Spectrometer (CMS) for food and beverage analysis. As an attendee, you will learn more about: How leading technologies and techniques affect food science researchers How to establish workflows that optimize …

Metal-based compounds have found utility in various fields such as clinical, energy, food safety and environmental to name a few. Creating the metal complex is the last step in a synthetic process, but it is critical to have the proper conditions for monitoring air-sensitive compounds to get the desire product and that side products are kept to …

 In this application note, the Advion expression® Compact Mass Spectrometer (CMS) coupled with the Advion AVANT™ UHPLC (LC/CMS) was used to measure the concentration of cannabinoids from commercially available CBD oils for a comparative test against the product labels.  The research in this application note was published in Cannabis Science & Technology Magazine May/June 2019 …

Introducing a new way to analyze and present mass spectral data, the Advion Interchim Scientific® Peak Express® patented software uses the delta spectrum (ΔS) to quickly and automatically detect significant peaks within mass spectra based on their relative change in intensity over time instead of their absolute intensity. Find impurities and minor components that would …

This webinar examines three different workflows surrounding compact mass spectrometry as they apply to cannabis law enforcement, it’s natural product research, and product control.

In this webinar, Advion’s Scientific Founder, Jack Henion, Ph.D., will discuss his research using a direct analysis probe coupled with the expression CMS to analyze chemical compounds in Cannabis. During this webinar you will learn more about: A simple, sensitive and selective ASAP sample introduction approach to measure the presence and relative quantitative composition of …

Thanks to the diminishing size and cost of mass spectrometers, coupled with their increasing robustness and ease of use, universities are now starting to furnish their undergraduate chemistry laboratories with this advanced analytic tool. “My favorite learning environment is the laboratory,” explains Paul A. Flowers, professor of analytical chemistry at University of North Carolina at …

The expression® CMS provides essential information quickly and improves the chemist’s workflow by using a direct analysis probe, otherwise known as ASAP® (Atmospheric Solids Analysis Probe) permits chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets. Chemists simply dip the closed end of …

The Atmospheric Solids Analysis Probe (ASAP™) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation. The inert ASAP (iASAP) is a modification of this technique, allowing easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glove …

Volatile Atmospheric Pressure Chemical Ionization (vAPCI) combined with Advion Interchim Scientific’s expression® compact mass spectrometer (CMS) is a fast and easy method to analyze the headspace of a sample with no additional sample prep. The vAPCI ion source is a simple, powerful tool for gas phase sample analysis. The technique can quickly and confidently identify …

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture. Watched the video and ready to learn more? View More Touch Express™ Details

Advion Interchim Scientific’s Plate Express® is ideal for fast, easy TLC/MS analysis. Coupled with the expression® Compact Mass Spectrometer (CMS), the TLC plate reader allows prep-free sampling and data in less than 30 seconds.

Advion’s direct atmospheric solids analysis probe, otherwise known as ASAP^®, permits chemists fast and reliable sample analysis of liquid and solid samples such as reaction mixtures, food samples, natural products and tablets.

Advion’s expression® CMS paired with the Atmospheric Solids Analysis Probe (ASAP®) can quickly and easily be used to screen an unidentified drug mixture in this mobile field testing dramatization.

We demonstrate a cost-effective UHPLC/CMS method for the analysis of chloramphenicol in milk with a detailed discussion of sensitivity, linear response range, carryover and robustness using the Advion expression® Compact Mass Spectrometer (CMS) and Advion AVANT™ UHPLC System. This application note was adapted from a poster that was presented at the 2019 ASMS Conference on …

In this application note, the Advion Interchim Scientific® AVANT™ UHPLC/CMS system is used to analyze casein proteins in whole milk extract to separate and detect β-casein-B, -A1, and -A2, as well as K-casein and αs1-casein variants. This method is also suitable for a quick, relative quantitation of the β-casein-B, -A1, and -A2 variants in standards …

During this webinar you will learn more about: A new type of mass spectrum: the Delta Spectrum (ΔS). The patented ΔS is able to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z. How to easily find adducts, dimers, fragments, side-reactions and other unexpected compounds at the click of …

In this application note, a simple and cost-effective SIM LC/MS analytical approach employing the Advion expression Compact Mass Spectrometer (CMS) is described for the quantitation of 25-hydroxyvitamin D2 and D3 in human serum.

Reaction monitoring is a key aspect in a range of chemistry environments from chemical synthesis to drug discovery to understanding natural products to protein synthesis. Understanding the optimal time to quench a reaction for maximum yield, as well as monitoring a reaction in real-time is vital to many medicinal and synthetic organic chemists. Advion Interchim …

In this webinar, Heather Walker from Sheffield University’s plant production and protection team explains how taking a compact mass spectrometer from the lab to the field helped optimise the team’s research. The webinar highlights the advantages of mobile mass spectrometry, and introduces a mobile mass spec vehicle that has been outfitted to optimize time in the …

Bring mass spectrometry into your classroom for remote or on-site learning with a training course for the expression® Compact Mass Spectrometer (CMS). Advion offers an affordable MS teaching package that includes: A compact, easy-to-use benchtop mass spectrometer for both students and researchers Recorded lectures and video lab content Lecture slides to share or adapt to your own teaching style …

Integrated Solutions for Food Authenticity, Characterization and Safety with the expression® Compact Mass Spectrometer, AVANT® (U)HPLC and SOLATION® ICP-MS  Your integrated laboratory solution for comprehensive testing of food, ingredients and natural products. Advion offers a full suite of analytical instrumentation for characterization, screening and purity determination, including: expression® CMS – The expression® Compact Mass Spectrometer (CMS) offers …

Integrated Solutions for Potency and Safety with the expression® Compact Mass Spectrometer and SOLATION® ICP-MS Outfit your lab with Advion Interchim Scientific’s line of custom cannabis solutions, including the expression® Compact Mass Spectrometer (CMS), the SOLATION® ICP-MS, and a customizable (U)HPLC solution. Your Complete Lab Solution: Advion Interchim Scientific provides integrated laboratory solutions for comprehensive cannabis …

For Direct Mass Analysis of Liquid & Solid Samples with the expression® CMS The direct atmospheric solids analysis probe, otherwise known as ASAP®, permits chemists fast and reliable sample analysis of liquid and solid samples such as reaction mixtures, food samples, natural products and tablets. Chemists simply dip the closed end of a glass capillary …

Provides simple, automated MS analysis in seconds, directly from TLC plates The Plate Express® is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion Interchim Scientific’s expression® compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique, chemists can quickly and confidently identify products even in complex mixtures without additional sample …

For Direct Mass Analysis of Air-Sensitive Samples, Catalysts and Organometallics at the Bench With the expression® CMS The Atmospheric Solids Analysis Probe (ASAP®) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation at the bench, right next to the reaction. The inert ASAP (iASAP) is a modification of this technique, allowing …

Providing simple, high-performance, LC/CMS with the expression® CMS Modular, stackable design, with many options provides custom solutions for both HPLC and UHPLC needs. From the simplest manual injection HPLC to a fully automated, streamlined UHPLC system and everything in-between, the Avant series can be configured to fit your analytical requirements and your budget. The AVANT® …

For One-Touch Mass Analysis of Solids, Liquids, Surfaces and Fibers with the expression® CMS  The Touch Express™ Open Port Sampling Interface (OPSI), is designed for simple sampling of surfaces, solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory.  …

Introduction There are many separation and detection methods that are available for the determination of saccharides. These include GC-MS with derivatization, HPLC-UV with derivatization, HPAEC-PAD (High-performance anion-exchange chromatography coupled with pulsed amperometric detection), and LC-MS. The availability of a sensitive and accurate method is still a challenge. For an LC-MS method, given the high polarity, …

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by the Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound and only unbound cortisol is excreted in urine. The measurement of cortisol in urine is typically used to diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although …

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective …

Introducing the new SOLATION® Inductively Coupled Plasma Mass Spectrometer (ICP-MS) – the ultimate instrument for multi-element analysis, the SOLATION® provides high sensitivity measurement of trace elements from a wide range of matrices including complex samples such as urine, serum, plasma, whole blood and tissue samples. Designed for ease of use, with intuitive software, the SOLATION® …

Quick and easy analysis methods for drugs of abuse are in high demand from health practitioners and law enforcement agencies on a global scale. In 2017, it was found that fentanyl, a fast-acting synthetic painkiller that is nearly 100 times stronger than morphine, has become the most widely abused synthetic opioid medicine – to the …

Chemical processes can be performed in two ways; in batch or in flow, each method having set advantages and disadvantages associated with them. Flow chemistry has gathered increasing attention over the past decade and is being readily adopted into academia to help improve synthetic routes, which maybe undesirable in batch, where outputs such as yield, …

Polycyclic aromatic hydrocarbons (PAHs) are neutral compounds containing multiple aromatic fused rings that are present in fossil fuels and can be formed from the incomplete combustion of organic material. In recent years, it has been well documented that several PAHs can be potentially carcinogenic via exposure or ingestion. In this application note, we analyze 16 PAHs by LC/CMS (EPA 610 …

The Touch Express™ Open Port Sampling Interface (OPSI), is designed for simple sampling of solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. Paired with the electrospray ion source of the expression® Compact Mass Spectrometer, the product incorporates …

Touch Express™ is a new sampling device for mass spec analysis using a technique developed by Gary Van Berkel and Vilmos Kertesz of Oak Ridge National Laboratory – the Open Port Sample Interface (OPSI). This fast, versatile sample inlet paired with the expression® Compact Mass Spectrometer (CMS) provides simple molecular weight determination of surfaces, solids and liquids in < 30s.

The Touch Express™ Open Port Sampling Interface (OPSI), is designed for simple sampling of solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. Paired with the electrospray ion source of the expression® Compact Mass Spectrometer, the product incorporates a …

The expression CMS coupled with the Atmospheric Solids Analysis Probe (ASAP®) is used to quickly identify the presence of artificial vanilla, as well as confirm the purity of products marketed as such. This technique provides a fast and easy method for purity analysis.

The expression® CMS coupled with the Atmospheric Solids Analysis Probe (ASAP®) is used to determine purity and detect adulterants in coconut oil. In this application note, pure coconut oil is tested against a sample of coconut oil adulterated with canola oil for comparative data analysis and a fast and easy method for purity analysis.

Learn more about Liquid Extraction Surface Analysis PLUS LC separation with the Advion TriVersa NanoMate® featuring new LESAPlus technology.

Shared live at the 254th ACS National Meeting in Washington, D.C. – John Matson, Ph. D., Matson Research Group on Macromolecular and Supramolecular Chemistry, Assistant Professor, Virginia Tech. Listen to the recorded workshop session highlighting the role of H2S in the human body and how compact mass spectrometry is used to assay peptides via direct injection for reaction …

Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP ®) …

Introducing a new type of mass spectrum, available exclusively in the Advion Peak Express™ software suite: the Delta Spectrum (ΔS). The ΔS is available with the expression® compact mass spectrometer (CMS) to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z in advance. With the Peak Express™ software featuring ΔS, …

Advion Interchim Scientific’s range of AVANT®, high performance, liquid chromatography systems can be used standalone with UV and UV/Vis detector options, or with the expression® compact mass spectrometer to provide seamlessly integrated LC/CMS under the full control of Advion Interchim Scientific’s simple, intuitive Mass Express software suite. Modular, stackable design, with many options, provides custom …

TLC/CMS, the atmospheric liquids and solids probe (ASAP), and the volatile APCI source provide direct analysis without sample preparation – even for air-sensitive compounds. With the daily need to analyze a variety of samples, these techniques are indispensable in a busy lab. Learn how a single instrument can be adapted to each of these sample …

The TriVersa NanoMate® LESA® is the latest in chip-based electrospray ionization technology from Advion Interchim Scientific®. It combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection and direct surface analysis into one integrated ion source platform. It allows scientists to obtain more information from complex samples than LC/MS alone.

Infusion based lipidomics analysis (shotgun Lipidomics) is an analysis strategy that involves the liquid extraction of lipids from samples such as blood, tissue homogenates or dried blood spots. This approach is suitable for a wide range of biomedical questions of lipid differentiation and lipid flux in the field of metabolic disease, neurological disorders, cancers or eye …

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.

The inert Atmospheric Solids Analysis Probe (iASAP) allows easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glovebox or Schlenk line.

Quant Express, an addition to Advion’s user-friendly Mass Express 4.0 software suite, features quantitation to create a fully integrated software system for expression CMS users.

Introducing a new type of mass spectrum, available exclusively in the Advion Peak Express™ software suite: the Delta Spectrum (ΔS). The ΔS is available with the expression compact mass spectrometer (CMS) to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z in advance. With the Peak Express™ software, you …

Turn your expression® CMS into a high resolution, exact mass instrument in its ability to provide elemental formulae. TAMI uses accurate centroiding and mass correction algorithms to provide a more accurate mass assignment.  In combination with isotope abundance analysis and careful consideration of chemical valence rules this provision of elemental formulae with a high level …

Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) has been utilized for determination of small molecules, lipids and proteins from a variety of surfaces such as tissue sections, plant material, medical devices, TLC plates or DBS cards. It allows direct surface analysis without sample preparation from spot sizes of 1 mm diameter by aspiration of extraction …

This webinar examines the workflow of a medicinal chemist as they utilize compact mass spectrometry techniques for drug discovery and disease prevention.

The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation.

At regular intervals throughout the year a local lawn service applies pesticides to the lawn surrounding the Advion headquarters in Ithaca, NY. The grass is very uniform and not a single dandelion or crabgrass plant is visible – so we wondered, what chemical do they use? After an application in the early spring, we sampled …

In this application note, we demonstrate the use of the Advion Interchim Scientific expression® CMS with a volatile APCI (vAPCI) ion source to analyze extra-virgin, virgin, and lampante olive oil samples. We show statistical analysis allowing us to categorize and identify olive oil samples by their grade. This technique allows us to test individual olive oil …

Cheese is one of the world’s most popular food types, with a wide variety available for consumers. The characteristic scents and flavors of cheeses stem from a complex mixture of chemicals, including free fatty acids. Use mass spectrometry to characterize the different volatile profiles of cheese. In this application note, we demonstrate the capability of …

Sudan Dyes are synthesized azo-dyes which are widely used to generate color in plastics, leather, fabrics, oil, waxes, etc. They are classified as Group 3 carcinogens by the International Agency for Research on Cancer (IARC) and are banned as food additives worldwide. However, in some countries these dyes are still occasionally used in order to …

In this application note, we demonstrate the use of the Advion expressionL CMS with an atmospheric solids analysis probe (ASAP) ion source to analyze two supplements (figure 1) that contain DMBA, a synthetic stimulant that has not been tested on humans. The substance is the chemical cousin to drug DBAA, which is currently banned by …

The new Liquid Extraction Surface Analysis (LESA) mode of the TriVersa NanoMate can now be combined with nano liquid chromatography and a smaller extraction drop size of 400 µm to result in a powerful novel surface analysis mode. Resulting in the detection of small molecule drugs from tissue sections, residue on plant material or lipid …

Residues and contaminants in the food chain are an increasing problem due to high production volumes, large area distribution and import/export of food items across the world. The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation. This combination is ideally suited …

Spatial lipid composition, distribution and regulation are very important factors for mediating lipid functionality and, when disrupted, can cause pathophysiological processes leading to cancer, obesity, atherosclerosis, and neurodegeneration. The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation. This combination is ideally …

The Montclair University team utilizes the Advion CMS in their undergraduate lab. Essential in the research-focused curriculum, the team was able to purchase the cost effective, small-footprint system to grow their lab capabilities. They later added an APCI module for their growing needs.

The Loughborough University team has utilized the expression® CMS vAPCI source for a variety of applications including breath analysis, monitoring flavor and fragrance, plant metabolomics, food authenticity and spoilage, and microbiological monitoring. With the use of the expression® CMS, the team was able to successfully execute detection required for these applications quickly and easily.

Explore how the expression CMS has been used by the Drug Discovery Unit at the University of Dundee. Learn how the medical chemistry team has integrated the instrument in to their everyday workflow. The team required a system with a small footprint that can be moved between labs, but was still capable of integrating with systems in their …

This application note demonstrates the use of the Advion Interchim Scientific expression® CMS (compact mass spectrometer) coupled with a volatile APCI (vAPCI) ion source to directly detect several key chemicals given off of meat as it spoils at ambient temperature. Evolution of putrescine, cadaverine, and indole were measured  over several days as meat spoiled.

The Advion deconvolution algorithm employs a combination of predictive charge envelope generation, overlap calculation with actual MS data acquired utilizing a maximum entropy goodness of fit approach followed by artifact removal through determination of peak significance. This novel approach allows for a rapid deconvolution over a wide mass range in seconds. It also allows a …

This application note suggests that a simple LC/MS screen of a relatively fresh sample of human whole blood collected from a lavender capped potassium EDTA anticoagulant blood sample applied to a cotton swab can be analyzed by full-scan positive ion or negative ion LC/MS using a compact single quadrupole mass spectrometer (expression CMS).

D. Tranchemontagne, N. Sousou, S. J. Prosser, J.D. Henion – Advion, Inc. & S. Orlowicz, S. Sadjadi, L. Snow – PhenoLogix The Advion Interchim Scientific expression® Compact Mass Spectrometer (CMS) coupled with Liquid Chromatography (LC) was used as a qualitative screening tool. This application note will demonstrate the screening of various drugs, including amphetamines, benzodiazepines, …

The CheMS user interface simplifies the mass spectrometry experience and makes it more accessible in chemistry and biochemistry laboratories. This allows the chemist to obtain optimal data without needing to be an expert in mass spectrometry. Available with the Advion expression® compact mass spectrometer (CMS) is a fast and easy tool that is ideal for …

The Liquid Extraction Surface Analysis (LESA) capability of the TriVersa NanoMate enables simple, direct nanoESI mass spectrometric analysis from a variety of surfaces. The new LESAPLUS allows for automated LESA experiments plus additional nano-LC separation through the ChipSoftX operating software with Developers Kit. This enhancement is ideal for direct tissue analysis.

ChipSoftX is an entirely new operating software for the TriVersa NanoMate automated nanoelectrospray source. Besides improvement in program compatibility with Windows and integration of existing software features, it also provides access to the new Developers Kit – a platform for customized method development with direct access to robot controls allowing entirely novel analysis workflows such …

Using Thin-Layer Chromatography with Compact Mass Spectrometry A sprig of mistletoe symbolizes a tradition of romance; however, reputed to be the “kiss of  death,” mistletoe is said by some to be so poisonous that humans can be killed if they  ingest the leaves or berries. In the spirit of the Holiday season and to ensure …

An office colleague has stolen a prized chocolate bar, and Dr. Eikel with the help of his partner, Dr. Henion, use an Atmospheric Solids Analysis Probe (ASAP) enabled expression CMS to determine whodunnit. This application note describes the process, and points the finger at the guilty culprit!

This note covers work carried out at Leeds University with co-workers from Durham University in the area of flow chemical synthesis using the expression CMS (Advion, Ithaca, NY). Two different reactions are described.

The analytical verification of compounds in organic syntheses is a challenging task. The sample is often directly taken out of the reaction mixture and therefore contains many impurities and matrix components. As a result, low-level sample preparation combined with a direct analysis method is highly beneficial. TLC/MS (thin layer chromatography – mass spectrometry) is such …

The analytical verification of compounds in organic syntheses is a challenging task. The sample is often directly taken out of the reaction mixture and therefore contains many impurities and matrix components. As a result, low-level sample preparation combined with a direct analysis method is highly beneficial. TLC/MS (thin layer chromatography – mass spectrometry) is such …

With the emergence of new protein therapeutics, including biosimilars, biobetters and ADCs, peptide mapping by LC/MS is becoming more commonly used for the identification of post-translational modifications (PTMs), glycosylation, and conjugation sites, as well as primary sequence confirmation. The purpose of this study is to provide guidelines for developing optimal LC running conditions with Aeris™ …

The scientific investigation of cultural heritage objects is the only access to knowledge about long-gone, ancient societies and their cultural, technological as well as their social  stage of development. In addition, the materials used by our ancestors, e.g. their textiles and the organic dyestuff to colorize these materials, allow researchers to draw some conclusions about …

Plate Express™ is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion Interchim Scientific’s expression® Compact Mass Spectrometer (CMS) this becomes TLC/CMS. Using this technique chemists can quickly and confidently identify products even in complex mixtures without additional sample …

This application note presents an online thin-layer chromatography (TLC)/CMS technique using the Advion Interchim Scientific expression® compact mass spectrometer (CMS) and Plate Express™ interface to provide compound structural information without sample preparation after TLC separation. A Suzuki reaction for the synthesis of 4-aminobiphenyl will be demonstrated. The online TLC/CMS technique provides rapid and accurate determination …

Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the  pharmaceutical drug development process and consequently half of all currently approved  drugs in the US are based on …

Analysis of the active components of the cannabis sativa plant is required both for law enforcement where these compounds are illegal and also as a tool for product control and optimization in the increasing number of legal markets for cannabis plant products. Whenever simple, unequivocal and legally defensible  analysis methods for the detection and quantification …

With decades of mass spectrometry and chemistry expertise, Advion Interchim Scientific has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting. The Advion Interchim Scientific expression® compact …

The ability to effectively screen passengers with minimal personal contact is critical. Ion mobility detectors used at many airports can be inaccurate and provide many false-positives and false-negatives. Advanced Imaging Technology (AIT) screening techniques are very useful for detecting concealed weapons and explosive devices located on passengers and/or in their belongings, however are unable to …

Aflatoxins (B1, B2, G1, G2) produced by certain fungi (Aspergillus flavus and Aspergillus parasificus) are toxic metabolites which have been associated with various diseases, such as aflatoxicosis, in livestock, domestic animals and humans throughout the world. Many methods can be used for Aflatoxins analysis, including TLC, HPLC, immunoassay, LCMS etc. Of all the methods, the …

Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.

The expression CMS with the direct analysis probe offers chemists the ability to rapidly analyze solids, liquids and powders without tedious and time consuming sample preparation.

A combination of ion-ion interaction chromatography and a compact mass spectrometer presents a cost effective and powerful analysis system for the detection and quantification of amino acids in complex mixtures without the need for extra sample processing steps such as derivatizations.

Surface analysis techniques have gained significant attention over the last couple of years with LESA being an interesting alternative to techniques such as SIMS or MALDI imaging. This note demonstrates practical applications for LESA in the material sciences.

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.

Quantitation of Perchlorate by Ion Chromatography with Suppressed Conductivity on the expression CMS Perchlorate is a synthetic chemical that is used in the manufacture of rocket fuel, fireworks, flares and explosives, and can also be present in bleaches and some fertilizers [1]. The EPA has devised drinking water regulations for Perchlorate to minimize its impact …

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, low cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile …

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, faster and lower cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile …

Via Direct Injection using a Compact Mass Spectrometer with extended mass range (CMSL) The CMSL is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — ideal for large molecule applications such as the analysis of proteins. Its small footprint makes it the instrument …

Using the expression CMSL compact mass spectrometer The CMSL is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — well-suited for large molecule applications such as the analysis of proteins. Its small footprint makes it the instrument of choice for space-restricted laboratories and …

Compact Mass Spectrometry for Fast, Quantitative VOC Screening Breath analysis is a valuable and widely-used technique that is gaining popularity in medical diagnostics, sports science, substance abuse and other fields where immediate, reliable detection of a variety of in-vivo compounds and their metabolites is required. However, the actual analysis can be complicated because of the type of …

Regardless of the legal status of cannabis and its chemical compounds, both the quality control in legal markets as well as the law enforcement of it’s illegal status require simple, unequivocal and legally defendable analysis methods for the detection and quantification of its major chemical compounds. Whenever a detector of high selectivity and sensitivity is …

Greater than 10 times more sensitive than LC/MS/MS for detection of low level, potentially active or toxic recirculating metabolites.

Fast, reproducible, and automated lipid analysis using chip-based nanoelectrospray infusion.

More analytes and higher sensitivity Developed in collaboration with Oak Ridge National Laboratory*, the liquid extraction surface analysis (LESA) capability of the TriVersa Nanomate® enables simple, direct ESI mass spectrometric analysis from a variety of surfaces.

Fully characterize oligosaccharides that are missed by LC/MS/MS. Download this product note to find out how.

The expression compact mass spectrometer (CMS) is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.

Automated static nano-ESI/MS/MS (Infusion MS/MS) is an easy-to-use and high-throughput approach to analyte identification. It is particularly useful in the field of shotgun lipidomics, which itself has great potential for biomarker discovery and gained some significant attention in the last couple of years (Schuhmann et al. 2012; Jung et al. 2011; Han et al. 2011). …

In many cases of routine protein identification, processing times become the major bottleneck at the core facility. Although a nano-LC/MS/MS approach is recognized as a general strategy for protein identification, the typical 30-120 min run-time prohibits fast turnaround times. The TriVersa NanoMate offers a more rapid approach for the infusion of the protein digest, with …

Presented by: Dr. Tom Covey In this web presentation Dr. Tom Covey describes how researchers can incorporate the fast, simple & direct method of LESA Clarity for AB SCIEX Mass Spec Systems into their labs. He shows data that illustrates how you can see more analytes with better sensitivity.

Presented by: John P. Shockcor, Director of Life Sciences Business Development, Waters Corp., Visiting Fellow, Dept. of Biochemistry, University of Cambridge, UK Description: Profiling low level components in a complex mixture of small molecules can be a challenging task. Although it may be possible to detect many low level components in a complex mixture, characterization …

Presented by: Dr. Daniel Eikel, Sr. Application Scientist – Advion, Inc. Description: Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel mass spectrometry-based surface-profiling technique (Kertez, et al., 2009) that can be utilized in drug distribution and metabolism studies. Potential advantages of LESA-MS are as follows: No radiolabeled compound is required Its overall sensitivity …

Presented by: Thomas Covey, Principal Research Scientist at AB SCIEX Thomas Covey describes how various organizations are incorporating the fast, simple, and direct method of LESA – Liquid Extraction Surface Analysis – into their labs. He shows data that illustrates how you can see more analytes with better sensitivity by combining LESA with mass spectrometry …

In this webinar, Dr. Han describes how he uses the TriVersa NanoMate’s chip-based nanoelectrospray ionization capabilities in infusion mode to obtain more information from complex samples and faster lipids analysis with no sample-to-sample carryover. The interests of Dr. Han’s laboratory have been focused on the altered lipid metabolism, trafficking, and homeostasis under patho(physio)logical conditions. Currently, …

Presented by: Gavin Reid, Associate Professor at Michigan State University A large number of studies have demonstrated that disruption of lipid metabolism or signaling pathways can play a key role in the onset and progression of human disease, including cancer and diabetes. Thus, a comparative analysis of changes in individual lipids or lipid profiles (i.e., …

The rapid identification of radiolabeled compounds would clearly be beneficial for applied clinical and preclinical tracers used for imaging with positron emission tomography (PET). The limited uptake of mass spectrometry in the imaging field has been due to several factors including concerns regarding adequate sensitivity, instrument footprint in the highly constrained space requirements for the …

Ultra (high) performance liquid chromatography (UPLC/UHPLC) is a relatively new technique, and is valued for its speed, efficiency and the quality of information provided. Many synthetic and medicinal chemistry laboratories are moving to this process to improve their workflows and save time.

The Advion expression Compact Mass Spectrometer (CMS) was coupled to a Normal Phase Flash Chromatography system for mass directed fraction collection. Typically a UV detector is used to monitor compounds eluting from Normal Phase columns. A limitation of the UV detector is that it relies on compounds having a chromophore in the chemical structure, hence …

Presented by: Ljiljana Paša-Tolić, Ph.D., Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory Description: Obtaining extended sequence coverage of intact proteins and characterizing multiple post-translational modification (PTM) sites can pose key technical challenges. In this webinar, we describe how we have implemented Advion’s TriVersa NanoMate® and RePlay® technologies to address these issues using an integrated …

This is one from a set of two application notes. In this application note, we review recovery and purity determination of two, three component standard mixtures by supercritical fluid chromatography (SFC) couped with the Advion expression Compact Mass Spectrometer (CMS). For the other application note on the fraction collection of a 0.2% impurity, click here. …

The expression CMS was developed with the chemist’s objectives and laboratory workflow in mind. Organic, Natural Product and Peptide chemists utilize many techniques to determine the progress, yield and purity of their reactions.

Supercritical fluid chromatography (SFC) is a fast growing technique. Initially used almost exclusively for only thermally labile and chiral compounds it is now becoming accepted as a versatile analytical technique applied across a broad range of compounds. It is faster and higher-throughput than regular HPLC and Preparative LC and becoming popular as a ‘green’ technique, with far lower solvent …

The expression CMS was designed by expert mass spectroscopists and chemists to create the ideal platform for scientists to get the most out of their research. Full integration (control, data acquisition, and analysis) with Agilent Technologies’ LC systems allows users a streamlined approach for their LC/CMS methods.

There must be better ways to do sample preparation for food matrices! And with good sample prep better analyses occur. It is human nature to resist change. Let us embrace new ways of doing things if they can be shown to be better, faster and easier.

Advion demonstrates a novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions employing either LC/MS or flow injection analysis (FIA).

Negative ion nanoelectrospray ionization mass spectrometry (nESI-MS) is notoriously challenging, even more so under the high aqueous conditions required for protein-ligand interactions at physiological conditions. However, we present a successful application of negative ion nESI-MS for the investigation of noncovalent interactions between Ψ-RNA and small molecule inhibitors.